Results 51 to 60 of about 151,392 (262)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Thermal expansion and thermodynamic properties of Janus WSSe monolayer: A first-principles study

AIP Advances
Materials with Janus structure play an important role in the emerging family of 2D materials. In this paper, based on a quasi-harmonic approach, the elastic, thermal expansion, and related thermodynamic properties of Janus WSSe monolayer are investigated
Fengli Cao, Xiaodong Qiu, Shengqi Chi, Gang Liu   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Development of Testing System on Thermal Expansion Valve Capacity

Zhileng xuebao, 2015
Thermal expansion valve’s flow characteristic under different conditions is one of the most important factors affecting refrigeration system performance. So it is necessary to detect the actual refrigerant flow of thermal expansion valve.
Yan Jiliang, Wang Yugang, Geng Liping, WangQingping   +3 more
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

A rational estimation of volumetric thermal expansion coefficient of Al2O3-water nanofluid in thermo-fluid application

Heliyon
A practical approach to augment the heat transmission effectiveness of thermo-fluid systems involves the utilization of nanofluids instead of traditional fluids.
Nahid Hasan, Md. Sheikh Rasel, Sumon Saha   +2 more
doaj   +1 more source

Colossal negative thermal expansion in reduced layered ruthenate

Nature Communications, 2017
Materials displaying negative thermal expansion have received interest as thermal-expansion compensators. Here, authors report very large total volume change associated with this effect in reduced calcium ruthenates and propose a microstructural origin ...
Koshi Takenaka, Yoshihiko Okamoto, Tsubasa Shinoda, Naoyuki Katayama, Yuki Sakai   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Progress of Research in Negative Thermal Expansion Materials: Paradigm Shift in the Control of Thermal Expansion

Frontiers in Chemistry, 2018
To meet strong demands for the control of thermal expansion necessary because of the advanced development of industrial technology, widely various giant negative thermal expansion (NTE) materials have been developed during the last decade.
Koshi Takenaka
doaj   +1 more source