Results 51 to 60 of about 764,055 (296)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Innovations in designing microwave electro-technological units with hybrid chambers

Spanish Journal of Agricultural Research, 2023
Aim of study: Microwave (MW) electro-technological units based on electromagnetic radiation of ultrahigh-frequency can involve thermal MW modification of dielectrics and non-thermal MW modification of polymers.
Midhat TUHVATULLIN, Yuri ARKHANGELSKY, Rustam AIPOV, Eduard KHASANOV   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Multi-Scale Characterisation of the Fire Hazards of Timber Cladding

Fire
Timber-clad facades, traditionally prevalent in North America and Scandinavia, are gaining popularity in central Europe and the UK for applications beyond low-rise buildings. Timber differs from typical cladding materials, such as masonry, due to its non-
Danny Hopkin, Michael Spearpoint, Yorgos Kanellopoulos, Carmen Gorska, Chris Mayfield   +4 more
doaj   +1 more source

An overview of laser surface modification of die steels [PDF]

, 2008
In recent years, surface modification using advanced heat source like laser has been replacing the conventional methods to produce amorphous microstructure via rapid solidification.
Aqida, S.N., Brabazon, Dermot, Maurel, M., Naher, Sumsun   +3 more
core  

Collective Dipole Bremsstrahlung in Fusion Reactions [PDF]

, 2001
We estimate the dipole radiation emitted in fusion processes. We show that a classical bremsstrahlung approach can account for both the preequilibrium and the thermal photon emission. We give an absolute evaluation of the pre-equilibrium component due to
C. Simenel, D. M. Brink, D. M. Brink, D. M. Brink, D. Pierroutsakou, E. Suraud, F. Amorini, G. F. Bertsch, H. B. Callen, H. Hofmann, J. D. Jackson, K. A. Snover, L. D. Landau, M. Cabibbo, M. Cinausero, M. Colonna, M. Di Toro, M. Di Toro, M. Papa, M. Sandoli, M. Trotta, P. Bonche, P. F. Bortignon, P. F. Bortignon, Ph. Chomaz, S. Flibotte, T. Papenbrock, V. Baran, V. Baran, V. Baran   +29 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Quantum corrections to thermodynamics of quasitopological black holes

, 2017
Based on the modification to area-law due to thermal fluctuation at small horizon radius, we investigate the thermodynamics of charged quasitopological and charged rotating quasitopological black holes.
Upadhyay, Sudhaker
core   +2 more sources

Aliovalent doping of CeO2 : DFT study of oxidation state and vacancy effects [PDF]

, 2014
The modification of CeO2 properties by means of aliovalent doping is investigated within the ab-initio density functional theory framework. Lattice parameters, dopant atomic radii, bulk moduli and thermal expansion coefficients of fluorite type Ce1−xMxO2−
Bultinck, Patrick, Cottenier, Stefaan, Van Driessche, Isabel, Van Speybroeck, Veronique, Vanpoucke, Danny   +4 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source