Results 81 to 90 of about 77,462 (276)

THERMAL NECROSIS - EXPERIMENTAL INVESTIGATION ON THERMAL EXPOSURE DURING BONE DRILLING PROCESS

International Journal of Research in Engineering and Technology, 2014
The process of bone drilling is an essential part of internal immobilization in orthopaedic and trauma surgery. So drill bit design also plays a vital role in surgery. Improper drill bit parameters will seriously affect the bone tissues and results thermal necrosis. This paper investigates the main concern of thermal necrosis during bone drilling.
openaire   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

The effect of saline coolant on temperature levels during decortication with a Midas Rex: An in vitro model using sheep cervical vertebrae.

Frontiers in Surgery, 2015
Decortication of bone with a high speed burr in the absence of coolant may lead to local thermal necrosis and decreased healing ability which may negatively impact clinical outcome.
Asher eLivingston, Tian eWang, Chris eChristou, Matthew H Pelletier, William R Walsh   +4 more
doaj   +1 more source

Characterisation of Ex Vivo Liver Thermal Properties for Electromagnetic-Based Hyperthermic Therapies

Sensors, 2020
Electromagnetic-based hyperthermic therapies induce a controlled increase of temperature in a specific tissue target in order to increase the tissue perfusion or metabolism, or even to induce cell necrosis.
Nuno P. Silva, Anna Bottiglieri, Raquel C. Conceição, Martin O’Halloran, Laura Farina   +4 more
doaj   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Pioglitazone Attenuates Tactile Allodynia and Thermal Hyperalgesia in Mice Subjected to Peripheral Nerve Injury

Journal of Pharmacological Sciences, 2008
To clarify the role of peroxisome proliferator activated receptor γ (PPARγ) in neuropathic pain, we examined the effect of pioglitazone, a PPARγ agonist, on tactile allodynia and thermal hyperalgesia in a neuropathic pain model.
Takehiko Maeda, Norikazu Kiguchi, Yuka Kobayashi, Masanobu Ozaki, Shiroh Kishioka   +4 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Implications of a local overproduction of tumor necrosis factor-α in complex regional pain syndrome

, 2011
Objective. To review the implications of a local overproduction of tumor necrosis factor-α for the pathogenesis and treatment of complex regional pain syndrome. Background.
Walker, S., Drummond, P.D.
core  

The Heat Transfer Modeling for Minimization of Thermal Necrosis in Hip Resurfacing Arthroplasty [PDF]

, 2009
In the past, the only option for replacing broken or otherwise malfunctioning hip bones was total hip replacement (THR), which involved the removal of the body's natural hip joint and replacing it with an entirely synthetic joint.
Kim, Hyunjin, Baskind, Daniel, Min, Flora, Park, Hyeongsu   +3 more
core  

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source