Results 41 to 50 of about 405,689 (266)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Impact of passive cooling techniques on the thermal behavior of residential buildings in hot and arid regions -An experimental study-

Journal of Building Materials and Structures, 2018
The thermal performance of the roof is one of the most important factors for a comfortable environment. As 50% of the thermal loads received by a building come from the roof, this research seeks to find the roofing system that opposes the transmission of
Wafa Athmani, Leila Sriti
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Experimental Study on the Factors Influencing the Thermal Performance of Vaccine Refrigeration Vehicles

Zhileng xuebao, 2023
To investigate the temperature distribution and optimize the thermal performance of a vehicle carriage for transporting refrigerated vaccines, a 3.9 m3 vehicle carriage working within the temperature range of 2–8 °C is examined in this study.
Zhao Juan, Zhang Zhongbin, Chen Meng, Gan Qiang, Gong Li, Song Ping, Deng Qingqing   +6 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Menstrual Health in Servicewomen: The Menstrual Cycle, Menstrual Disturbances, and Occupational Consequences

Sports Medicine - Open
Background Most women serving in the military do so during their reproductive life and enter service at a young gynecological age. This review provides an overview of the menstrual cycle and summarizes the evidence for menstrual cycle disturbances in the
Ritva S. Mikkonen, Holly McClung, Gabrielle Giersch, Jeroen Van Cutsem, Helen Wright, Thomas J. O’Leary, Julie P. Greeves   +6 more
doaj   +1 more source

Analysing the Effect of Substrate Properties on Building Envelope Thermal Performance in Various Climates

Energies, 2020
Existing regulations on the thermal efficiency of building envelope assemblies are based on the steady state thermal properties of substrate materials.
Kishor T. Zingre, Kiran Kumar D. E. V. S., Man Pun Wan   +2 more
doaj   +1 more source

Thermal Performance Evaluation of Domed Roofs [PDF]

Linköping Electronic Conference Proceedings, 2011
Domed roofs have been used in Iran and many other countries to cover large buildings such as mosques, shrines, churches, schools. They have been also employed in other buildings like bazaars or market places in Iran due to their favorable thermal performance.
Ahmadreza K. Faghih, Mehdi N. Bahadori
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source