Results 81 to 90 of about 1,665,855 (306)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Solar Total Energy Project (STEP) Performance Analysis of High Temperature Energy Storage Subsystem [PDF]

, 1984
The 1982 milestones and lessons learned; performance in 1983; a typical day's operation; collector field performance and thermal losses; and formal testing are highlighted.
Moore, D. M.
core   +1 more source

Cool Roof Impact on Building Energy Need: The Role of Thermal Insulation with Varying Climate Conditions [PDF]

, 2019
Cool roof effectiveness in improving building thermal-energy performance is affected by different variables. In particular, roof insulation level and climate conditions are key parameters influencing cool roofs benefits and whole building energy ...
Cabeza, Luisa F., Cotana, Franco, Gracia Cuesta, Alvaro de, Piselli, Cristina, Pisello, Anna Laura, Saffari Tabalvandani, Mohammad   +5 more
core   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Melting of PCM in a thermal energy storage unit: Numerical investigation and effect of nanoparticle enhancement [PDF]

, 2012
The present paper describes the analysis of the melting process in a single vertical shell-and-tube latent heat thermal energy storage (LHTES), unit and it is directed at understanding the thermal performance of the system.
Adine, Agyenim, Akgun, Akgun, Aydin, Brinkmann, Bugaje, Cabeza, Ettouney, Ho, Hosseinizadeh, Ismail, Ismail, Jany, Jones, Keles, Khodadadi, Khodadadi, Lacroix, Mennon, Mettawee, Pal, Pincemina, Sari, Seeniraj, Shamsundar, Shmueli, Sparrow, Trp, Trp, Voller, Voller, Xuan, Zhang   +33 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

“Perversity, Futility, Jeopardy”: An Economic Analysis of the Attack on Gun Control [PDF]

, 1996
A relatively new way for utilizing the thermal performance of heat pipes is to use nanofluids as working fluids in the heat pipes. Heat pipes are effective heat transfer devices in which the nanofluid operates in the two phases, evaporation and ...
Cook, Philip J., Leitzel, James A.
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Thermal performance of hybrid thermal interface graphene nanocomposites

Journal of Physics: Conference Series, 2020
Abstract This research examines thermal performance of hybrid thermal interface graphene nanocomposites. Graphene nanoflakes were added in different wt. fractions to thermoplastic polymeric materials (polyacrylate and other polymers) followed by thin film preparation.
D D Babenko, A A Dmitriev, A S Dmitriev, I A Mikhailova   +3 more
openaire   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source