Results 41 to 50 of about 1,013,313 (306)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Research Progress and Prospect of Thermal Flutter of Hypersonic Vehicles

Hangkong gongcheng jinzhan, 2022
Hypersonic vehicle is subjected to severe aerodynamic load and aerodynamic heating during the flight.Thus structural dynamic stability and response caused by aerodynamic force and aerodynamic heating should be fully considered in the design process of ...
CHEN Haoyu, WANG Binwen, SONG Qiaozhi, LI Xiaodong   +3 more
doaj   +1 more source

Temperature induced pore fluid pressurization in geomaterials [PDF]

, 2010
The theoretical basis of the thermal response of the fluid-saturated porous materials in undrained condition is presented. It has been demonstrated that the thermal pressurization phenomenon is controlled by the discrepancy between the thermal expansion ...
Ghabezloo, Siavash, Sulem, Jean
core   +3 more sources

Thermal response of jointed rock masses inferred from infrared thermographic surveying (Acuto test-site, Italy) [PDF]

, 2018
The Mediterranean region is affected by considerable daily and seasonal temperature variations due to intense solar radiation. In mid-seasons, thermal excursions can exceed tens of degrees thus influencing the long-term behaviour of jointed rock masses ...
Fiorucci, Matteo, Marmoni, Gian Marco, Martino, Salvatore, Mazzanti, Paolo   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Laboratory Investigation of Heterogeneous Metamorphic Rocks and Their Spatial Distribution of Thermal Conductivity

Energies
Assessing the variation in the thermal conductivity of heterogeneous rock materials can be critical when upscaling models to simulate geothermal system operation, especially for petrothermal systems, where conduction dominates over convection. This study’
Miora Mirah Rajaobelison, Mathieu Des Roches, Jasmin Raymond, Stéphanie Larmagnat   +3 more
doaj   +1 more source

Smart Heating and Cooling Heat Pump System by Standing Column Well and Cross-Mixing Balancing Well Heat Exchangers

Applied Sciences, 2020
Standing column well (SCW) geothermal heat exchanger permits a bleeding discharge of less than 20% in the event of a maximum load, which is an inappropriate method of using underground water. In this study, the existing operational method of two adjacent
Donggyu Kim, Myungkwan Lim, Byeongseok Yu, Changhee Lee   +3 more
doaj   +1 more source

Resistivity Response of Thermally Treated Granite During the Compression Test

ACS Omega, 2022
To determine the stress and damage state of rock mass is important for many geotechnical engineering. To study the feasibility of resistivity measurement in characterizing the damage and stress state, the resistivity measurement, uniaxial compression test, and incremental loading-unloading compression test were carried out on granite samples with ...
Feng Liang, Shiwan Chen, Kexun Zheng, Chao Qin, Xingyuan Jiang   +4 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source