Results 61 to 70 of about 314,980 (299)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Assessing the applicability of thermal response testing to energy piles [PDF]
, 2014 Deep foundations are increasingly being used, not just to carry structural loads, but also to act as heat exchangers as part of a ground source heat pump system.
Loveridge, F.A. +3 more
core
Research Progress and Prospect of Thermal Flutter of Hypersonic Vehicles
Hangkong gongcheng jinzhan, 2022 Hypersonic vehicle is subjected to severe aerodynamic load and aerodynamic heating during the flight.Thus structural dynamic stability and response caused by aerodynamic force and aerodynamic heating should be fully considered in the design process of ...
CHEN Haoyu +3 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Applied Sciences, 2020 Standing column well (SCW) geothermal heat exchanger permits a bleeding discharge of less than 20% in the event of a maximum load, which is an inappropriate method of using underground water. In this study, the existing operational method of two adjacent
Donggyu Kim +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Resistivity Response of Thermally Treated Granite During the Compression Test
ACS Omega, 2022 To determine the stress and damage state of rock mass is important for many geotechnical engineering. To study the feasibility of resistivity measurement in characterizing the damage and stress state, the resistivity measurement, uniaxial compression test, and incremental loading-unloading compression test were carried out on granite samples with ...
Feng Liang +4 more
openaire +2 more sources
Modeling of thermally induced skew variations in clock distribution network [PDF]
, 2011 Clock distribution network is sensitive to large thermal gradients on the die as the performance of both clock buffers and interconnects are affected by temperature.
Macii, Alberto +5 more
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source