Results 81 to 90 of about 314,980 (299)

Comparative Analysis of Different Methodologies Used to Estimate the Ground Thermal Conductivity in Low Enthalpy Geothermal Systems

open access: yesEnergies, 2019
In ground source heat pump systems, the thermal properties of the ground, where the well field is planned to be located, are essential for proper geothermal design.
Cristina Sáez Blázquez   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Thermal Response Testing Results of Different Types of Borehole Heat Exchangers: An Analysis and Comparison of Interpretation Methods

open access: yesEnergies, 2017
The design phase of ground source heat pump systems is an extremely important one as many of the decisions made at that time can affect the system’s energy performance as well as installation and operating costs.
Angelo Zarrella   +13 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The measurement of vascular and neurological function in workers exposed to hand-transmitted vibration [PDF]

open access: yes, 1999
Four methods for measuring disorders of vascular function and neurological function associated with occupational exposure to hand-transmitted vibration have been defined by reference to the available literature.
Lindsell, Christopher John   +1 more
core  

Maternal response to environmental unpredictability [PDF]

open access: yes, 2015
This study was funded by a postdoctoral fellowship to MB (SFRH/BPD/82259/2011) and with a “Bolsista CAPES/BRASIL,” (Project A058/2013) to AMVMS.Mothers are expected to use environmental cues to modify maternal investment to optimize their fitness ...
Lopes, Isabel   +14 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Analysis of Influencing Factors on Soil Thermal Conductivity Test in Ground Source Heat Pump

open access: yesZhileng xuebao, 2012
A three dimensional numerical model of ground source heat pump system was established. The effects of testing time, starting time, borehole radius, initial ground temperature and heat injection rate on identified thermal conductivity of the deep ground ...
Wang Fenghao   +3 more
doaj  

Experiences with performing a thermal response test in boreholes for heat pumps [PDF]

open access: yesActa Montanistica Slovaca, 2006
This paper presents a Thermal Response Test (TRT) performed in two testing boreholes for heat pumps in the Czech Republic. The TRT is a special in-situ technique used abroad for the determination of key parameters needed for the proper borehole design ...
Jiří Ryška
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

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