Results 71 to 80 of about 224,589 (307)
On Higher Order Structures in Thermodynamics
, 2020 We present the development of the approach to thermodynamics based on measurement. First of all, we recall that considering classical thermodynamics as a theory of measurement of extensive variables one gets the description of thermodynamic states as ...
Valentin Lychagin, Mikhail Roop
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Journal of Noncommutative Geometry, 2014 The Witt construction describes a functor from the category of Rings to the category of characteristic 0 rings. It is uniquely determined by a few associativity constraints which do not depend on the types of the variables considered, in other words, by integer polynomials.
Marcolli, Matilde, Thorngren, Ryan
openaire +4 more sources
Derivation of the Critical Point Scaling Hypothesis Using Thermodynamics Only
, 2020 Based on the foundations of thermodynamics and the equilibrium conditions for the coexistence of two phases in a magnetic Ising-like system, we show, first, that there is a critical point where the isothermal susceptibility diverges and the specific heat
Víctor Romero-Rochín
core +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Averaged Optimization and Finite-Time Thermodynamics
, 2020 The paper considers typical extremum problems that contain mean values of control variables or some functions of these variables. Relationships between such problems and cyclic modes of dynamical systems are explained and optimality conditions for these ...
Anatoly Tsirlin, Ivan Sukin
core +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Thermodynamics and Rate Thermodynamics
Journal of Statistical PhysicsApproach of mesoscopic state variables to time independent equilibrium sates (zero law of thermodynamics) gives birth to the classical equilibrium thermodynamics. Approach of fluxes and forces to fixed points (equilibrium fluxes and forces) that drive reduced mesoscopic dynamics gives birth to the rate thermodynamics that is applicable to driven ...
openaire +3 more sources
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source