Results 111 to 120 of about 49,629 (277)

Acyl CoA-binding protein in brown adipose tissue acts as a negative regulator of adaptive thermogenesis

Molecular Metabolism
Objective: Defective activity of brown adipose tissue (BAT) is linked to obesity and cardiometabolic diseases. While much is known regarding the biological signals that trigger BAT thermogenesis, relatively little is known about the repressors that may ...
Albert Blasco-Roset, Tania Quesada-López, Alberto Mestres-Arenas, Joan Villarroya, Francisco J. Godoy-Nieto, Rubén Cereijo, Celia Rupérez, Ditte Neess, Nils J. Færgeman, Marta Giralt, Anna Planavila, Francesc Villarroya   +11 more
doaj   +1 more source

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

Clinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams, Bonnie Grant, Richard Quinton, Channa N. Jayasena   +3 more
wiley   +1 more source

Akebia Saponin D Targeting Ubiquitin Carboxyl‐Terminal Hydrolase 4 Promotes Peroxisome Proliferator‐Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity

MedComm
Promoting thermogenesis in adipose tissue to enhance energy expenditure is widely regarded as a promising strategy for obesity treatment. However, the development of effective thermogenic drugs remains challenging.
Lang Chen, Dong‐Hai Liu, Yu‐Xi Li, Song Yang, Wei‐Hua Jia, Liang Peng, Hong‐Lin Liu, Xing‐Bo Wang, Bing Hu, Yu‐Chen Wang, Calvin Pan, Aldons Jake Lusis, Li‐Hong Liu, Li‐Li Gong   +13 more
doaj   +1 more source

Human iPSC‐Derived Vascularised Lung Organoids for Modelling COPD and Pulmonary Hypertension

Cell Proliferation, EarlyView.
Vascularised lung organoids (vLOs) that faithfully mimic human lung tissue architecture and disease pathology are critical for advancing pulmonary research but remain challenging to generate. Here, we developed a robust self‐organisation protocol to produce vLOs with cellular heterogeneity and functional vasculature. The engineered blood vessels within
Simin Jiang, Liangliang Tian, Jingge Qu, Yi Hong, Dian Chen, Zihang Pan, Huanyu Long, Lanhe Chu, Weijing Kong, Qiyang Yao, Xiaojing Ma, Yun Zhao, Baihui Ma, Kai Wang, Yahong Chen   +14 more
wiley   +1 more source

Correction to “Schisantherin A: Remodeling Gut Microbiota to Activate the Gut–Immune–Neural–Adipose Axis for Thermogenesis”

iNew Medicine, EarlyView.
wiley   +1 more source

Intravenous Oxytocin Does Not Affect Glucose‐Regulating Hormones or Markers of Bone Turnover During Graded Glucose Infusion in Healthy Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Oxytocin has been proposed to exert glucose‐stabilising effects via modulation of pancreatic hormone secretion and to play a role in bone homeostasis. However, human data under controlled conditions are limited. We investigated the effects of intravenously infused oxytocin during a graded glucose infusion on glucose‐regulating hormones and
Vivian Kliim‐Hansen, Ida M. Gether, Aliya M. Thomas, Anne‐Marie Ellegaard, Miriam G. Pedersen, Jens J. Holst, Bolette Hartmann, Filip K. Knop, Lærke S. Gasbjerg, Asger B. Lund   +9 more
wiley   +1 more source

Liver Fibrosis and IRS1 rs2972146 Are Associated With Weight Loss Response After Metabolic Bariatric Surgery

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background and Aims Weight loss after metabolic bariatric surgery (MBS) is heterogeneous, and the contribution of liver histology and genetic susceptibility to insufficient weight loss (IWL) or weight regain (WR) remains unclear. We assessed the prevalence of IWL and WR after MBS and their association with liver histology and metabolic ...
Felice Cinque, Marica Meroni, Sara Badiali, Miriam Longo, Erika Paolini, Elisa Galfrascoli, Giovanna Oberti, Giuseppina Pisano, Gabriele Maffi, Matteo Mureddu, Elena Corbetta, Valentina Scimè, Emma Calzavara, Francesca Alletto, Annalisa Cespiati, Luigi Boni, Anna Ludovica Fracanzani, Paola Dongiovanni, Rosa Lombardi   +18 more
wiley   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice

eLife
Endotherms increase the rate of metabolism in metabolic organs as one strategy to cope with a decline in the temperature of the external environment. However, an additional major contributor to maintenance of body temperature in a cold environment is ...
Yuna Izumi-Mishima, Rie Tsutsumi, Tetsuya Shiuchi, Saori Fujimoto, Momoka Taniguchi, Mizuki Sugiuchi, Manaka Tsutsumi, Yuko Okamatsu-Ogura, Takeshi Yoneshiro, Masashi Kuroda, Kazuhiro Nomura, Hiroshi Sakaue   +11 more
doaj   +1 more source

Association of BCAAs/BCKAs with pancreatic steatosis in patients with type 2 diabetes mellitus: A cross‐sectional study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims To examine the association between branched‐chain α‐keto acids (BCKAs) and pancreatic steatosis in patients with type 2 diabetes (T2DM). Methods This cross‐sectional study was conducted from January 2023 to March 2025. Upper abdominal computerized tomography was performed, pancreatic volume (PV), PV index (PVI), CT attenuation of pancreas
Jie Gao, Pijun Cheng, Fusong Jiang, Wenmin Li, Yingying Shi, Wenjun Wang, Liang Wang, Tao Lei, Yunxiang Zang, Jun Lu   +9 more
wiley   +1 more source