Results 1 to 10 of about 3,314,026 (137)

Emerging roles of histone deacetylases in adaptive thermogenesis

Frontiers in Endocrinology, 2023
Brown and beige adipose tissues regulate body energy expenditure through adaptive thermogenesis, which converts energy into heat by oxidative phosphorylation uncoupling.
Ruonan Zhou, Ruonan Zhou, Yue Cao, Yue Cao, Yingying Xiang, Yingying Xiang, Penghua Fang, Wenbin Shang, Wenbin Shang   +8 more
doaj   +6 more sources

Mitochondrial Lipid Signaling and Adaptive Thermogenesis [PDF]

Metabolites, 2021
Thermogenesis is an energy demanding process by which endotherms produce heat to maintain their body temperature in response to cold exposure. Mitochondria in the brown and beige adipocytes play a key role in thermogenesis, as the site for uncoupling ...
Helaina Von Bank, Mae Hurtado-Thiele, Nanami Oshimura, Judith Simcox   +3 more
doaj   +6 more sources

Impact of Adaptive Thermogenesis in Mice on the Treatment of Obesity [PDF]

Cells, 2020
Obesity and associated metabolic diseases have become a priority area of study due to the exponential increase in their prevalence and the corresponding health and economic impact.
Paula Mera, Serra D, Laura Herrero
exaly   +6 more sources

New Advances in Adaptive Thermogenesis: UCP1 and Beyond [PDF]

Cell Metabolism, 2019
Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like obesity and type 2 diabetes.
Lawrence Kazak, Bruce Spiegelman, Edward Chouchani   +2 more
exaly   +4 more sources

Adipose Tissue‐Resident Sphingomonas Paucimobilis Suppresses Adaptive Thermogenesis by Reducing 15‐HETE Production and Inhibiting AMPK Pathway

Advanced Science
Obesity represents a low‐grade chronic inflammation status, which is associated with compromised adaptive thermogenesis. However, the mechanisms underlying the defective activation of thermogenesis in chronic inflammation remain unclear.
Yucheng Zhu, Ruiqi Yang, Zhangchao Deng, Bohua Deng, Kun Zhao, Chen Dai, Gang Wei, YanJiang Wang, Jinshui Zheng, Zhuqing Ren, Wentao Lv, Yingping Xiao, Zhinan Mei, Tongxing Song   +13 more
doaj   +3 more sources

Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic

Cells, 2021
Thyroid hormones (TH) contribute to the control of adaptive thermogenesis, which is associated with both higher energy expenditure and lower body mass index.
Yanis Zekri, Frédéric Flamant, Karine Gauthier   +2 more
doaj   +4 more sources

Neuronal control of adaptive thermogenesis [PDF]

Frontiers in Endocrinology, 2015
The obesity epidemic continues rising as a global health challenge, despite the increasing public awareness and the use of lifestyle and medical interventions. The biomedical community is urged to develop new treatments to obesity.
Xiaoyong eYang, Hai-Bin eRuan
doaj   +3 more sources

Amino acids contribute to adaptive thermogenesis. New insights into the mechanisms of action of recent drugs for metabolic disorders are emerging

Pharmacological Research, 2023
Adaptive thermogenesis is the heat production by muscle contractions (shivering thermogenesis) or brown adipose tissue (BAT) and beige fat (non-shivering thermogenesis) in response to external stimuli, including cold exposure.
Chiara Ruocco, Alexis Elias Malavazos, Maurizio Ragni, Michele O. Carruba, Alessandra Valerio, Gianluca Iacobellis, Enzo Nisoli   +6 more
doaj   +2 more sources

microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity

Nature Communications, 2021
Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone,
Takahiro Horie, Tetsushi Nakao, Yui Miyasaka, Tomohiro Nishino, Shigenobu Matsumura, Fumiko Nakazeki, Yuya Ide, Masahiro Kimura, Shuhei Tsuji, Randolph Ruiz Rodriguez, Toshimitsu Watanabe, Tomohiro Yamasaki, Sijia Xu, Chiharu Otani, Sawa Miyagawa, Kazuki Matsushita, Naoya Sowa, Aoi Omori, Jin Tanaka, Chika Nishimura, Masataka Nishiga, Yasuhide Kuwabara, Osamu Baba, Shin Watanabe, Hitoo Nishi, Yasuhiro Nakashima, Marina R. Picciotto, Haruhisa Inoue, Dai Watanabe, Kazuhiro Nakamura, Tsutomu Sasaki, Takeshi Kimura, Koh Ono   +32 more
doaj   +2 more sources

Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-α/hepcidin axis

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Adaptive thermogenesis is a metabolic switch that converts the metabolic status of fat tissue from energy conservation to energy release into heat, thereby significantly attenuating the energy burden of obesity and diabetes. It is well known
Soonkyu Chung, Bhanwar Lal Puniya, Jean-Christophe Deschemin   +2 more
exaly   +2 more sources