Cold‐Induced Adaptive Thermogenesis in Lean and Obese [PDF]
Obesity, 2010 On entering a cold environment, people react by increasing insulation and energy expenditure (EE). However, large interindividual differences exist in the relative contribution of each mechanism. Short‐term studies revealed that obese subjects increase EE (i.e., adaptive thermogenesis) less than lean subjects, which might have implications for the ...
Wijers, S.L. +2 more
openaire +4 more sources
Acyl CoA-binding protein in brown adipose tissue acts as a negative regulator of adaptive thermogenesis [PDF]
Mol MetabObjective Defective activity of brown adipose tissue (BAT) is linked to obesity and cardiometabolic diseases. While much is known regarding the biological signals that trigger BAT thermogenesis, relatively little is known about the repressors that may ...
Albert Blasco-Roset +11 more
semanticscholar +2 more sources
Adaptive Thermogenesis in a Mouse Model Lacking Selenoprotein Biosynthesis in Brown Adipocytes [PDF]
Int J Mol Sci, 2021 Selenoproteins are a class of proteins with the selenium-containing amino acid selenocysteine (Sec) in their primary structure. Sec is incorporated into selenoproteins via recoding of the stop codon UGA, with specific cis and trans factors required ...
Lucia A. Seale +8 more
semanticscholar +2 more sources
Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing
Cell Reports, 2020 SUMMARY Almost all life forms can detect and decode light information for adaptive advantage. Examples include the visual system, in which photoreceptor signals are processed into virtual images, and the circadian system, in which light entrains a ...
Russell van Gelder +2 more
exaly +2 more sources
Deoxycholic acid derived from the gut microbiota involved in the regulation of adaptive thermogenesis in response to dietary protein restriction in plateau pika [PDF]
MicrobiomeBackground Most winter-active mammals experience protein restriction. Gut microbiota is a key regulator of host energy homeostasis during nutrient deficiency, yet cross talk between microbiota and factors (e.g., hormones, signaling molecules) that ...
Fuyu Shi +12 more
doaj +2 more sources
Prohibitin Inactivation in Adipocytes Results in Reduced Lipid Metabolism and Adaptive Thermogenesis Impairment [PDF]
Diabetes, 2021 Prohibitin-1 (PHB) is a multifunctional protein previously reported to be important for adipocyte function. PHB is expressed on the surface of adipose cells, where it interacts with a long-chain fatty acid (LCFA) transporter.
Zhanguo Gao +5 more
semanticscholar +2 more sources
Reduced adaptive thermogenesis during acute protein-imbalanced overfeeding is a metabolic hallmark of the human thrifty phenotype. [PDF]
Am J Clin Nutr, 2021 BACKGROUND The human thrifty phenotype is characterized by a greater decrease in 24-h energy expenditure (24EE) during fasting due to relatively higher eucaloric 24EE in sedentary conditions, both of which are indicative of greater propensity to weight ...
Tim Hollstein +4 more
semanticscholar +2 more sources
Sensory neurons expressing calcitonin gene-related peptide α regulate adaptive thermogenesis and diet-induced obesity [PDF]
Mol Metab, 2021 Objectives Heat-sensory neurons from the dorsal root ganglia (DRG) play a pivotal role in detecting the cutaneous temperature and transmission of external signals to the brain, ensuring the maintenance of thermoregulation.
Kuldeep Makwana +10 more
semanticscholar +2 more sources
PLoS ONE, 2011 BackgroundEnvironmental stress can accelerate the directional selection and evolutionary rate of specific stress-response proteins to bring about new or altered functions, enhancing an organism's fitness to challenging environments.
Jie Yang +8 more
doaj +2 more sources
Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation [PDF]
Nature Communications, 2020 Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse ...
Hui J. Wang +22 more
doaj +2 more sources