Results 51 to 60 of about 4,471,539 (245)

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

Cell, 1998
Adaptive thermogenesis is an important component of energy homeostasis and a metabolic defense against obesity. We have cloned a novel transcriptional coactivator of nuclear receptors, termed PGC-1, from a brown fat cDNA library. PGC-1 mRNA expression is
P. Puigserver, Zhidan Wu, Cheol Won Park, R. Graves, M. Wright, B. Spiegelman   +5 more
semanticscholar   +1 more source

Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats [PDF]

, 2012
Low-carbohydrate, high-fat (LC-HF) diets are popular for inducing weight loss in overweighed adults. Adaptive thermogenesis increased by specific effects of macronutrients on energy expenditure has been postulated to induce this weight loss.
Bidlingmaier, Martin, Korbinian Pieper (158350), Müller, H.H., Brigitte Mauracher, William Abplanalp (158346), Marc Slawik (152756), Bidlingmaier, M., Ramisch, Juliane, Mauracher, B., Tschöp Matthias H., Mauracher, Brigitte, Ramisch, J., Bidlingmaier Martin, Pieper, Korbinian, Slawik, Marc, Pieper, K., Juliane Ramisch, Maximilian Bielohuby (158339), Bielohuby Maximilian, Müller Hans-Helge, Matthias H Tschöp, Korbinian Pieper, Tschöp, Matthias H., Matthias J Betz, Matthias J. Betz (158336), Beuschlein, Felix, Abplanalp William, Felix Beuschlein, Matthias H. Tschöp (158357), Abplanalp, William, Pieper Korbinian, Brigitte Mauracher (158342), Beuschlein, F., Hans-Helge Müller (158349), Bielohuby, M., Tschöp, M.H., Bielohuby, Maximilian, Müller, Hans-Helge, William Abplanalp, Mauracher Brigitte, Betz, Matthias J., Marc Slawik, Martin Bidlingmaier (150187), Abplanalp, W., Martin Bidlingmaier, Juliane Ramisch (158353), Betz, M.J., Beuschlein Felix, Slawik, M., Maximilian Bielohuby, Slawik Marc, Ramisch Juliane, Hans-Helge Müller, Felix Beuschlein (158361), Betz Matthias J.   +54 more
core   +2 more sources

Energy expenditure during overfeeding

Nutrition & Metabolism, 2006
The large inter-individual variation in weight gain during standardized overfeeding together with a weight gain that is often less than theoretically calculated from the energy excess suggest that there are differences between persons in the capacity to ...
Westerterp Klaas R, Joosen Annemiek MCP
doaj   +1 more source

Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α. [PDF]

PLoS ONE, 2016
The β3-adrenergic receptor (AR) signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation.
Jihyun Kim, Vivian E Fernand, Tara M Henagan, Jeho Shin, Peter Huypens, Susan Newman, Thomas W Gettys, Ji Suk Chang   +7 more
doaj   +1 more source

Does adaptive thermogenesis occur after weight loss in adults? A systematic review

British Journal of Nutrition, 2021
Adaptive thermogenesis (AT) has been proposed to be a compensatory response that may resist weight loss (WL) and promote weight regain. This systematic review examined the existence of AT in adults after a period of negative energy balance (EB) with or ...
Catarina L. Nunes, Nuno Casanova, R. Francisco, A. Bosy-Westphal, Mark Hopkins, L. Sardinha, A. Silva   +6 more
semanticscholar   +1 more source

Adaptive thermogenesis: Turning on the heat [PDF]

Current Biology, 1998
Brown adipocytes play important roles in the regulation of fat storage and body temperature, by virtue of their ability to uncouple mitochondrial fuel oxidation and ATP synthesis. The discovery of a tissue-specific transcriptional coactivator provides new insights into the regulation of thermogenesis by brown adipocytes.
openaire   +2 more sources

AMPK in the Ventromedial Nucleus of the Hypothalamus: A Key Regulator for Thermogenesis

Frontiers in Endocrinology, 2020
Obesity has become a global health issue, but effective therapies remain very limited. Adaptive thermogenesis promotes weight loss by dissipating energy in the form of heat, thereby representing a promising target to counteract obesity.
Hailan Liu, Hailan Liu, Yong Xu, Yong Xu, Fang Hu   +4 more
doaj   +1 more source

MnSOD serves as the central molecule in adaptive thermogenesis (MnSOD functions as a thermoreceptor)

Advances in Redox Research, 2021
MnSOD catalyzes superoxide dismutation via temperature-dependent 'fast cycle' and 'slow cycle' pathways. Higher temperature promotes the formation of the product inhibition complexes, and the slow cycle pathway becomes mainstream in the overall ...
Xu Zhang, Hua Liu, Depei Zhang
doaj   +1 more source

Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance

The Journal of Clinical Investigation, 2022
Brown adipose tissue (BAT), a crucial heat-generating organ, regulates whole-body energy metabolism by mediating thermogenesis. BAT inflammation is implicated in the pathogenesis of mitochondrial dysfunction and impaired thermogenesis.
Yanrui Huang, Jenny H. Zhou, Haifeng Zhang, Alberto Canfran-Duque, Abhishek K. Singh, Rachel J. Perry, Gerald I. Shulman, Carlos Fernandez-Hernando, Wang Min   +8 more
doaj   +1 more source

Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

Cell Reports, 2021
Summary: Cold-induced thermogenesis in endotherms demands adaptive thermogenesis fueled by mitochondrial respiration and Ucp1-mediated uncoupling in multilocular brown adipocytes (BAs).
Esther Paulo, Yun Zhang, Ruchi Masand, Tony L. Huynh, Youngho Seo, Danielle L. Swaney, Margaret Soucheray, Erica Stevenson, David Jimenez-Morales, Nevan J. Krogan, Biao Wang   +10 more
doaj   +1 more source