Results 61 to 70 of about 4,471,539 (245)

Adaptive thermogenesis in adipocytes: Is beige the new brown? [PDF]

Genes & Development, 2013
One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat.
Wu, Jun, Cohen, Paul, Spiegelman, Bruce M.   +2 more
openaire   +4 more sources

Adaptive Thermogenesis Driving Catch-Up Fat Is Associated With Increased Muscle Type 3 and Decreased Hepatic Type 1 Iodothyronine Deiodinase Activities: A Functional and Proteomic Study

Frontiers in Endocrinology, 2021
Refeeding after caloric restriction induces weight regain and a disproportionate recovering of fat mass rather than lean mass (catch-up fat) that, in humans, associates with higher risks to develop chronic dysmetabolism. Studies in a well-established rat
Celia Di Munno, R. Busiello, Julie Calonne, A. Salzano, J. Miles-Chan, A. Scaloni, M. Ceccarelli, P. de Lange, A. Lombardi, R. Senese, F. Cioffi, T. Visser, R. Peeters, A. Dulloo, E. Silvestri   +14 more
semanticscholar   +1 more source

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source

Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1α Pathway

Pharmaceuticals, 2022
Pharmacological activation of adaptive thermogenesis to increase energy expenditure is considered to be a novel strategy for obesity. Peroxisome-proliferator-activated receptor γ co-activator-1α (PGC-1α), which serves as an inducible co-activator in ...
Dandan Chen, Yanan Duan, Shuxiang Yu, Xinwen Zhang, Ni Li, Jingya Li   +5 more
doaj   +1 more source

Prolonged Treatment with Grains of Paradise (Aframomum melegueta) Extract Recruits Adaptive Thermogenesis and Reduces Body Fat in Humans with Low Brown Fat Activity.

Journal of Nutritional Science and Vitaminology, 2021
Increasing adaptive thermogenesis through the activation of brown adipose tissue (BAT) is a promising practical strategy for preventing obesity and related disorders.
T. Yoneshiro, M. Matsushita, Jun Sugita, S. Aita, T. Kameya, Hiroki Sugie, M. Saito   +6 more
semanticscholar   +1 more source

Association of energy availability with resting metabolic rates in competitive female teenage runners: a cross-sectional study

Journal of the International Society of Sports Nutrition, 2021
Background Resting metabolic rate (RMR) has been examined as a proxy for low energy availability (EA). Previous studies have been limited to adult athletes, despite the serious health consequences of low EA, particularly during adolescence.
Norimitsu Kinoshita, Eriko Uchiyama, Kazuko Ishikawa-Takata, Yuka Yamada, Kenta Okuyama   +4 more
doaj   +1 more source

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.

Genes & Development, 2012
Certain white adipose tissue (WAT) depots are readily able to convert to a "brown-like" state with prolonged cold exposure or exposure to β-adrenergic compounds.
F. Fisher, Sandra Kleiner, N. Douris, Elliott C. Fox, Rina J. Mepani, Francisco Verdeguer, Jun Wu, A. Kharitonenkov, J. Flier, E. Maratos-Flier, B. Spiegelman   +10 more
semanticscholar   +1 more source

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

eLife, 2017
Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain ...
Luke K Burke, Tamana Darwish, Althea R Cavanaugh, Sam Virtue, Emma Roth, Joanna Morro, Shun-Mei Liu, Jing Xia, Jeffrey W Dalley, Keith Burling, Streamson Chua, Toni Vidal-Puig, Gary J Schwartz, Clémence Blouet   +13 more
doaj   +1 more source

The impact of dietary factors on the function of brown and beige adipose tissues—implications on health and disease

Frontiers in Nutrition
The development of strategies that promote the activation of adaptive thermogenesis in brown and beige adipose tissues is expected to lead to advances in the prevention and treatment of obesity, diabetes, and cardiovascular diseases.
Bruna Bombassaro, Gabriela Batitucci, Marcela Reymond Simoes, Eliana P. Araujo, Eliana P. Araujo, Licio A. Velloso, Licio A. Velloso, Licio A. Velloso   +7 more
doaj   +1 more source

Skeletal muscle mitochondrial uncoupling, adaptive thermogenesis and energy expenditure [PDF]

, 2011
PURPOSE OF REVIEW: The prevalence of obesity is still increasing, despite obesity treatment strategies that aim at reducing energy intake. In addition to this, exercise programmes designed to increase energy expenditure have only a low efficiency and ...
Schrauwen, P., Berg, S.A.A. van den, van Dijk, K, Sjoerd AA van den Berg, Patrick Schrauwen, Lichtenbelt, W.V., Ko Willems van Dijk, Dijk, K.W. van, van Marken Lichtenbelt, W.D., van den Berg, S.A., Wouter van Marken Lichtenbelt   +10 more
core   +2 more sources