Results 81 to 90 of about 4,471,539 (245)

Genetic and epigenetic interactions in adaptive thermogenesis pathways in association with obesity from a Public Health Genomics perspective

Italian Journal of Public Health
Background: studying and apprehending the pathways and mechanisms by which overweight and obesity trigger complex disease progression is of prime importance for the development of therapy and prevention measures of this major public health burden.
C. Brettfeld, Stephanie Englert, E. Aumueller, A. Haslberger   +3 more
semanticscholar   +1 more source

Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity.

Clinical science, 2021
Chemokine (C-C motif) ligand 5 (CCL5) and CCR5, one of its receptors have been reported to be highly expressed in white adipose tissue (WAT) and are associated with the progression of inflammation and the development of insulin resistance in obese humans
Pei-Chi Chan, L. Hung, Jiung-Pang Huang, Y. Day, Chao-Lan Yu, Feng-Chih Kuo, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh   +8 more
semanticscholar   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling

Molecular Metabolism, 2019
Objective: Gsα couples multiple receptors, including the melanocortin 4 receptor (MC4R), to intracellular cAMP generation. Germline inactivating Gsα mutations lead to obesity in humans and mice.
Min Chen, Eric A. Wilson, Zhenzhong Cui, Hui Sun, Yogendra B. Shrestha, Brandon Podyma, Christina H. Le, Benedetta Naglieri, Karel Pacak, Oksana Gavrilova, Lee S. Weinstein   +10 more
doaj   +1 more source

Topical menthol, a pharmacological cold mimic, induces cold sensitivity, adaptive thermogenesis and brown adipose tissue activation in mice

Diabetes, obesity and metabolism
Brown adipose tissue (BAT) thermogenesis has profound energy‐expanding potential, which makes it an attractive target tissue to combat ever‐increasing obesity and its other associated metabolic complications. Although it is fairly accepted that cold is a
Polina Sankina, Roshan Lal, P. Khare, S. von Hörsten, Lars Fester, Vaishali Aggarwal, Katharina Zimmermann, M. Bishnoi   +7 more
semanticscholar   +1 more source

Glucagon Is Essential for Adaptive Thermogenesis in Brown Adipose Tissue [PDF]

Endocrinology, 2014
AbstractGlucagon, a counterregulatory hormone to insulin, serves as a regulator of glucose homeostasis and acts in response to hypoglycemia. Earlier studies have shown that glucagon administration induces thermogenesis in experimental animal models.
Keita, Kinoshita, Nobuaki, Ozaki, Yusuke, Takagi, Yoshiharu, Murata, Yoshiharu, Oshida, Yoshitaka, Hayashi   +5 more
openaire   +2 more sources

Temperature homeostasis disruption and hypothalamic alterations in experimental drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Objective Elevated body temperature may increase seizure risk, yet the relationship between thermoregulation and seizures, as well as the underlying mechanisms, remains poorly understood. We investigated whether thermoregulatory control is altered in experimental temporal lobe epilepsy (TLE), as such impairment could reduce the ability of ...
Rossella Di Sapia, Akash Bera, Omar Mamad, James D. Mills, Benjamin Villasana‐Salazar, Giada Lavigna, Edoardo Micotti, Manuela Conticello, Asmin Alam, Roberto Chiesa, Francesca Pagani, Roberta Frapolli, Angelo M. Lavecchia, Christodoulos Xinaris, Eleonora Aronica, Andre Altmann, Teresa Ravizza, Sanjay M. Sisodiya, David C. Henshall, Annamaria Vezzani   +19 more
wiley   +1 more source

Fundamental mechanisms of thermogenesis. [PDF]

, 2006
Thermogenesis is an obligatory consequence of cellular metabolism and is identified as a unique property of homeotherms which have to maintain constant their body temperature in a cold environment.
Ricquier, Daniel, Daniel Ricquier
core   +1 more source

Constitutive Serotonin Tone as a Modulator of Brown Adipose Tissue Thermogenesis: A Rat Study

Life, 2023
Brown adipose tissue (BAT), an important regulator of thermogenic and metabolic processes, is considered a promising target to combat metabolic disorders.
Maja Kesić, Petra Baković, Vladimir Farkaš, Robert Bagarić, Darko Kolarić, Jasminka Štefulj, Lipa Čičin-Šain   +6 more
doaj   +1 more source

Evidence for the existence of adaptive thermogenesis during weight loss [PDF]

British Journal of Nutrition, 2001
The present study was performed to further investigate the adaptive component of thermogenesis that appears during prolonged energy restriction. Fifteen obese men and twenty obese women underwent a 15-week weight-loss programme. During this programme, body weight and composition as well as resting energy expenditure (REE) were measured at baseline ...
E, Doucet, S, St-Pierre, N, Alméras, J P, Després, C, Bouchard, A, Tremblay   +5 more
openaire   +2 more sources