Results 161 to 170 of about 49,768 (263)

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Irregular dietary patterns (e.g., late breakfast, reduced meal frequency) upregulate the bai gene cluster by disrupting cholecystokinin (CCK) release rhythms and gut microbiota circadian rhythms, leading to increased production of secondary bile acids, particularly DCA. High‐carbohydrate dietary patterns increase gallstone risk (OR = 1.329).
Rui Li, Yong Zhang, Kaishuang Cai, Shaojun Deng, Chaofeng Tan, Yunjie Li, Wenjin Liang   +6 more
wiley   +1 more source

Alternative Receptor Signaling for the Selective and Multifaceted Regulation of Human Brown Adipocytes. [PDF]

Int J Mol Sci
Takeda Y.
europepmc   +1 more source

Orai1-mediated Ca²⁺ entry regulates lipolysis and mitochondrial activation in brown adipose thermogenesis. [PDF]

Exp Mol Med
Kim S, Nguyen PA, Park KS, Cha SK, Namkung J.   +4 more
europepmc   +1 more source

Adipocyte‐Derived KIF13B Aggravates Obesity‐Associated Metabolic Dysfunction via LRP1/PPARγ Signaling

MedComm, Volume 7, Issue 10, October 2026.
Adipocyte‐derived KIF13B promotes LRP1 localization and nuclear LRP1–PPARγ transcriptional activity, thereby enhancing adipogenic gene expression, lipid accumulation, and obesity‐associated metabolic dysfunction. Adipocyte‐specific Kif13b deletion disrupts this LRP1/PPARγ axis, suppresses adipogenic programming, reduces adipose expansion, and protects ...
Guolin Miao, Zhaoling Li, Lianxin Zhang, Yitong Xu, Ziwei Wang, Zixun Wang, Aiden Xian, Liwen Zheng, Jingxuan Chen, Yufei Han, Chunhua Shan, Kaikai Lu, Ming Tao, Ling Zhang, Weiguang Zhang, Wei Huang, Yuhui Wang, Rui Wei, Erdan Dong, Xunde Xian   +19 more
wiley   +1 more source

Sarcolipin-SERCA uncoupling as a plausible heat source for sustaining fever. [PDF]

Front Physiol
Humaid A, Tupling AR.
europepmc   +1 more source

The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Bile acids (BAs) serve not only as emulsifiers for lipid digestion but also as essential signaling molecules, governing various physiological and pathological processes through their interaction with the farnesoid X receptor (FXR) and the takeda G protein‐coupled receptor 5 (TGR5).
Jie Liu, Kui Sun, Hongmei Liu, Meiyang Zhu, Chunmeng Li, Yuqi He, Lin Qin   +6 more
wiley   +1 more source

Hypothalamus-Peripheral Organ Crosstalk in Energy Metabolism: A Bidirectional Regulatory Network. [PDF]

Endocrinol Metab (Seoul)
Hong Y, Shin S, Cho SK, Kim KW.
europepmc   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, Volume 41, Issue 10, Page 975-997, October 2026.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

Understanding adipocyte heterogeneity across species, depot, and disease. [PDF]

Biochem Soc Trans
Kitto ES, Kult Perry S, Emont MP.
europepmc   +1 more source

Resting Metabolic Rate Rises in Pregnancy, but Energy Intake and Active Expenditure Remain Stable: A Pilot Study

Australian and New Zealand Journal of Obstetrics and Gynaecology, Volume 66, Issue 5, October 2026.
ABSTRACT Background Adequate nutrition during pregnancy is well established; however, how pregnancy affects energy metabolism, particularly the relationship between energy intake, expenditure and maternal mass, remains poorly understood. Current dietary recommendations advise increasing energy intake across pregnancy, but these are based on theoretical
Georgia S. Clarke, Kai Liu, Eskedar Getie Mekonnen, Jessica A. Grieger   +3 more
wiley   +1 more source