Results 211 to 220 of about 49,624 (286)

Dual Glucagon and GLP‐1 Receptor Agonist Survodutide Improves Biomarkers of Beta‐Cell Function and Insulin Sensitivity in People With Type 2 Diabetes or Living With Overweight/Obesity

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8242-8253, September 2026.
ABSTRACT Aims This post hoc analysis evaluated the effect of survodutide on beta‐cell function, insulin sensitivity, and glucose biomarkers in two phase 2 trial populations. Materials and Methods Trial 1404‐0002 randomised 413 participants with type 2 diabetes on metformin to receive survodutide, placebo, or semaglutide over 16 weeks.
Elif I. Ekinci, Sandra González Maldonado, Anna Unseld, Jorge Arrubla Martinez, Anita M. Hennige, Corinna Schoelch   +5 more
wiley   +1 more source

Adipose Tissue Browning in MASLD and Its Molecular Mechanisms and Metabolic Crosstalk. [PDF]

Curr Obes Rep
Guerrero JJG, Del Rosario MAS, Encarnacion PC, Lin CS, Chuang LT, Notarte KI, Zhou J, Wang CH, Chang CW, Li WC.   +9 more
europepmc   +1 more source

Functional Hyperthermia Presenting as Fever of Unknown Origin With Normal Inflammatory Markers in an Adolescent

Journal of General and Family Medicine, Volume 27, Issue 5, September 2026.
Ryuichi Minoda Sada, Hirofumi Miyake, Hiroyuki Akebo, Kazuhiro Hatta   +3 more
wiley   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

The Therapeutic Potential of Purmorphamine Across Disease Models

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Purmorphamine (PUR) is a trisubstituted purine compound that selectively activates Smoothened receptor, thereby initiating Sonic Hedgehog (Shh) signalling—a pathway critical for embryonic patterning, neuronal specification and tissue regeneration across multiple organ systems. Dysregulation of Shh signalling has been implicated in degenerative
Ashis Dhar, Ahnaf Dil Sharar, Saikarthik Papisetty, Mohammad Bydon, F. M. Moinuddin   +4 more
wiley   +1 more source

Increased Brown Adipose Tissue Thermogenesis in Phenylketonuria. [PDF]

MedComm (2020)
López-Rey N, Cabaleiro A, Pata MP, Peyrou M, Estévez-Salguero Á, Fernández-Sanmartín P, Morgan DA, Ferreira V, Sánchez-Pintos P, Folgueira C, Diéguez C, Urisarri A, González-García I, Seoane LM, Rahmouni K, Villarroya F, Couce ML, Nogueiras R, López M.   +18 more
europepmc   +1 more source

Local Trade‐Offs Shape Flower Size Evolution Across Arabidopsis thaliana Distribution

Molecular Ecology, Volume 35, Issue 17, September 2026.
ABSTRACT The remarkable variation in floral form and size is thought to have driven the evolutionary radiation of angiosperms and has traditionally been attributed to pollinator‐mediated selection on floral displays, yet emerging evidence indicates that abiotic environmental factors can also generate and filter variation in flower size.
Kevin Sartori, Clàudia F. Mestre, Md Jonaid Hossain, Aurélien Estarague, Elza Gaignon, Pierre Moulin, Jesse R. Lasky, Denis Vile, Francois Vasseur, Cyrille Violle, Adrien Sicard   +10 more
wiley   +1 more source

Mulberry Leaf Water Extract Ameliorates Impaired Glucose Tolerance via the Gut Microbiota/SCFAs/AMPKα1 Axis in Adipose Tissue. [PDF]

Pharmaceuticals (Basel)
Yang Y, Zhao Y, Du Y, Xie J, Liu S, Liu G, Bu S, Wang G, An Y, Wang M, Shan Z, Zhao B.   +11 more
europepmc   +1 more source

Transcriptional benchmark dose modeling of ultraviolet radiation‐induced genomic activation in mouse skin

Photochemistry and Photobiology, Volume 102, Issue 5, Page 1159-1168, September/October 2026.
Exposure to ultraviolet radiation (UV‐R) from tanning equipment increases skin cancer risk through molecular changes, but genomic thresholds remain unclear. Using mice, we examined dose‐ and time‐dependent gene expression after erythemally‐weighted UV‐R doses (0–40 mJ/cm2).
Sami S. Qutob, Samantha P. M. Roesch, Sandy Smiley, Pascale V. Bellier, Andrew Williams, Kate B. Cook, Matthew J. Meier, Andrea Rowan‐Carroll, Carole L. Yauk, James P. McNamee, Vinita Chauhan   +10 more
wiley   +1 more source