Brown adipocyte and browning thermogenesis: metabolic crosstalk beyond mitochondrial limits and physiological impacts [PDF]
Adipocyte, 2023 Brown adipocytes were proposed to reverse metabolic conditions such as obesity and diabetes, which make them potential for therapeutic applications.
Van Thi-Tuong Nguyen +2 more
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Glucagon-like Peptide-1 Improves Fatty Liver and Enhances Thermogenesis in Brown Adipose Tissue via Inhibiting BMP4-Related Signaling Pathway in High-Fat-Diet-Induced Obese Mice [PDF]
International Journal of Endocrinology, 2021 Objective. Glucagon-like peptide-1 (GLP-1) receptor agonist is effective in decreasing blood glucose and body weight. It could improve fatty liver with unclear mechanisms.
Xingchun Wang +6 more
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Continuous cold exposure induces an anti-inflammatory response in mesenteric adipose tissue associated with catecholamine production and thermogenin expression in rats [PDF]
Endocrine Regulations, 2016 Objective. Continuous exposure to cold leads to an activation of adaptive thermogenesis in the brown adipose tissue and induction of brown/beige cell phenotype in the white adipose tissue.
Vargovic P., Manz G., Kvetnansky R.
doaj +4 more sources
The Role of FNDC5/Irisin in Cardiovascular Disease [PDF]
CellsDisorders of cardiomyocyte metabolism play a crucial role in many cardiovascular diseases, such as myocardial infarction, heart failure and ischemia–reperfusion injury.
Maciej Grzeszczuk +2 more
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Evaluation of Browning Agents on the White Adipogenesis of Bone Marrow Mesenchymal Stromal Cells: A Contribution to Fighting Obesity [PDF]
Cells, 2021 Brown-like adipocytes can be induced in white fat depots by a different environmental or drug stimuli, known as “browning” or “beiging”. These brite adipocytes express thermogenin UCP1 protein and show different metabolic advantages, such as the ability ...
Girolamo Di Maio +6 more
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Hybridization with mountain hares increases the functional allelic repertoire in brown hares [PDF]
Scientific Reports, 2021 Brown hares (Lepus europaeus Pallas) are able to hybridize with mountain hares (L. timidus Linnaeus) and produce fertile offspring, which results in cross-species gene flow.
Jaakko L. O. Pohjoismäki +3 more
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Molecular evolution of TRPC4 regulatory sequences supports a role in mammalian thermoregulatory adaptation [PDF]
PeerJBackground Proteins encoded by the canonical transient receptor potential (Trpc) gene family form transmembrane channels involved in diverse signal-transduction pathways. Trpc4 has been shown necessary for the induction of nonshivering thermogenesis (NST)
Robert S. Cornman
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The Role of Irisin in Cancer Disease
Cells, 2021 Irisin (Ir) is an adipomyokine that is involved in the regulation of metabolic processes. It also influences processes related to inflammation, including cancer.
Agnieszka Pinkowska +3 more
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Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
Molecular Medicine, 2020 The hereditary aspect of obesity is a major focus of modern medical genetics. The genetic background is known to determine a higher-than-average prevalence of obesity in certain regions, like Oceania.
Anna E. Pravednikova +7 more
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Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome
Frontiers in Endocrinology, 2019 White adipose tissue (WAT) is an endocrine organ highly integrated in homeostasis and capable of establishing ways of communicating and influencing multiple metabolic processes.
Lidia I. Arhire +5 more
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