Thermoreceptor TRPV1 regulates body weight and blood pressure in the absence of thermogenin [PDF]
Hypertension Research, 2022 S. Shibata
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Exclusive occurrence of thermogenin antigen in brown adipose tissue [PDF]
FEBS Letters, 1982 Thermogenin is the purine‐nucleotide binding polypeptide in brown adipose tissue mitochondria (M r 32 000) which confers upon these mitochondria the ability to produce heat. An enzyme‐linked immunosorbent assay (ELISA) has been developed to demonstrate and quantitate the occurrence of thermogenin antigen in small amounts of tissue, and thus to ...
B. Cannon, Anders Hedin, J. Nedergaard
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In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid. [PDF]
Biochemical Journal, 1996 The effects of retinoic acid (RA) isomers (all-trans-RA and 9-cis-RA) on the appearance of uncoupling protein (UCP; thermogenin), the only unequivocal molecular marker of the brown adipocyte differentiated phenotype, have been investigated in primary cultures of brown adipocytes, in the brown adipocyte cell line HIB 1B and directly in intact mice.
P. Puigserver +5 more
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Physiological activation of brown adipose tissue destabilizes thermogenin mRNA [PDF]
FEBS Letters, 1987 The amount of mRNA coding for the brown fat specific uncoupling protein thermogenin was followed in the brown adipose tissue of adult mice. As expected, cold exposure or norepinephrine injection caused an increase in the amount of thermogenin mRNA. However, contrary to expectation, the half‐life of thermogenin mRNA was dramatically reduced, from about ...
A. Jacobsson, B. Cannon, J. Nedergaard
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Effects of dietary essential fatty acids on active thermogenin content in rat brown adipose tissue.
The Journal of Nutrition, 1983 Rats were fed diets providing either 0.3% (low EFA), 3% (control) or 10% (high EFA) of the energy as essential fatty acids. (All diets provided 20 energy percent of fat.) Both the experimental groups had a lower body weight than the controls. Small differences were found between the groups in many traditional parameters of brown adipose tissue activity
J. Nedergaard, W. Becker, Barbara Cannon
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Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool. [PDF]
Biochemical Journal, 1992 The induction and degradation of the brown-fat-specific uncoupling protein thermogenin in brown fat cell cultures was investigated. Cultures were initiated with undifferentiated precursor cells from young mice and the amount of thermogenin was determined by immunoblotting.
P. Puigserver +6 more
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MEASUREMENT OF THERMOGENIN SYNTHESIS IN BROWN ADIPOSE TISSUE (BAT) [PDF]
Pediatric Research, 1984 Thermogenin is a mitochondrial inner membrane protein which mediates non-shivering thermogenesis in BAT. It has a molecular mass of 32,000 Da and acts by uncoupling mitochondria to produce heat. We report a method of measuring its synthesis. Polysomes were isolated from BAT of developing rabbits and translated in a reticulocyte protein synthesizing ...
J. Arnold, H. Patel, K. B. Freeman
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Irisin and Cardiometabolic Disorders in Obesity: A Systematic Review. [PDF]
Int J Inflam, 2023 Background. Overweight and obesity are global health issues, impacting a significant portion of young adults. Obesity is a complex condition influenced by genetics and environmental factors, leading to increased susceptibility to cardiovascular diseases (CVDs), hypertension, dyslipidemia, and insulin resistance.
Pinho-Jr JDS +6 more
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A study of GDP binding to purified thermogenin protein from brown adipose tissue. [PDF]
Biochemical Journal, 1988 1. The binding of GDP to purified thermogenin protein was studied by using fluorescence spectroscopy and equilibrium dialysis. 2. GDP binding to thermogenin diminished fluorescence emission in a concentration-dependent manner that exhibited saturation. 3.
R. French, M. Gore, D. York
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Postnatal recruitment of brown adipose tissue is induced by the cold stress experienced by the pups. An analysis of mRNA levels for thermogenin and lipoprotein lipase. [PDF]
Biochemical Journal, 1989 In order to investigate the postnatal recruitment process, gene expression in the brown adipose tissue of rat pups was followed during the first 20 h of life. In normal pups, the level of mRNA coding for the uncoupling protein thermogenin increased markedly but gradually within the first 24 h.
M. Obregon +5 more
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