Results 21 to 30 of about 502 (114)
Biochemical and Biophysical Research Communications, 1987 The amount of mRNA coding for the brown-fat specific, uncoupling protein thermogenin was followed perinatally in fetuses and newborns from normal and hypothyroid rat dams. Although the growth of the fetuses and newborns was normal in the hypothyroid group, they had a lower amount of thermogenin mRNA already in-utero, and the dramatic postnatal increase
María Jesús Obregón +4 more
semanticscholar +4 more sources
Journal of Biological Chemistry, 1990 In order to examine the control of expression of the gene coding for the brown fat specific uncoupling protein thermogenin (UCP), brown fat cells isolated as undifferentiated precursors from the interscapular brown adipose tissue of young mice were grown in culture.
S. Rehnmark +4 more
semanticscholar +3 more sources
Norepinephrine‐induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture [PDF]
FEBS Letters, 1990 Synthesis of the brown adipocyte‐specifie mitochondrial uncoupling protein thermogenin (UCP) is demonstrated here in brown adipocytes differentiated in culture from precursor cells. By immunoblotting, no UCP was detectable in untreated multilocular adipocytes. The synthesis of UCP was stimulated by norepinephrine at physiological concentrations and was
D. Herron +5 more
semanticscholar +3 more sources
Stabilization of the mRNA for the uncoupling protein thermogenin by transcriptional/translational blockade and by noradrenaline in brown adipocytes differentiated in culture: a degradation factor induced by cessation of stimulation? [PDF]
Biochemical Journal, 1994 The stability of the mRNA coding for the uncoupling protein thermogenin was investigated in mouse brown-fat cells differentiated in culture. After 7 days in culture, the cells were stimulated for 24 h with noradrenaline, and a high level of thermogenin mRNA was then observed.
C. Picó +5 more
semanticscholar +3 more sources
Cold exposure induces different uncoupling-protein thermogenin masking/unmasking processes in brown adipose tissue depending on mitochondrial subtypes. [PDF]
Biochemical Journal, 1994 The effect of cold exposure on thermogenic parameters such as mitochondrial protein content, GDP-binding and uncoupling protein (UCP) levels in different mitochondrial fractions from rat brown adipose tissue has been investigated. Rats were exposed from 12 h to 5 days at 4 degrees C, and three mitochondrial fractions were isolated by differential ...
M. Moreno +6 more
semanticscholar +3 more sources
Dermal white adipose tissue development and metabolism: The role of transcription factor Foxn1
The FASEB Journal, Volume 37, Issue 10, October 2023., 2023 Role of transcription factor Foxn1 in regulation of the adipogenic process and lipid metabolism in intact and post‐wounded skin. Abstract Intradermal adipocytes form dermal white adipose tissue (dWAT), a unique fat depot localized in the lower layer of the dermis.
Katarzyna Walendzik +5 more
wiley +1 more source
Journal of Paediatrics and Child Health, Volume 58, Issue 7, Page 1201-1208, July 2022., 2022 Aim Hypothermia is associated with increased morbidity and mortality in preterm infants. A local audit revealed 60% preterm infants ≤32 weeks gestation and/or very low birth weight (VLBW) infants (<1500 g) had an abnormal body temperature at admission.
Tarun S Singh +8 more
wiley +1 more source
Inhibition of CXXC5 function reverses obesity‐related metabolic diseases
Clinical and Translational Medicine, Volume 12, Issue 4, April 2022., 2022 CXXC5 is abundantly expressed in the adipose tissues from obese‐T2DM patients. Ablation of Cxxc5 resists obesity‐related metabolic diseases. KY19334, a small molecule blocking CXXC5‐Dvl binding, reverses obesity‐related metabolic diseases with adult tissue remodelling. Effects on glycaemic control with KY19334 prolong during post‐treatment.
Seol Hwa Seo +7 more
wiley +1 more source
BioMed Research International, Volume 2021, Issue 1, 2021., 2021 Obesity, as the most common metabolic disorder in the world, is characterized by excess body fat. This study is aimed at determining the effects of melatonin supplementation on body weight, nody mass index (BMI), waist circumference (WC), and body fat mass percentage (BFMP) in people with overweight or obesity.
Salman Mohammadi +8 more
wiley +1 more source
Targeting Mitochondrial Biogenesis with Polyphenol Compounds
Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021 Appropriate mitochondrial physiology is an essential for health and survival. Cells have developed unique mechanisms to adapt to stress circumstances and changes in metabolic demands, by meditating mitochondrial function and number. In this context, sufficient mitochondrial biogenesis is necessary for efficient cell function and haemostasis, which is ...
Leila Chodari +9 more
wiley +1 more source