Results 31 to 40 of about 502 (114)
BioEssays, Volume 42, Issue 11, November 2020., 2020 Heart regeneration is strongly associated with low‐metabolic ectotherms; it is proposed that it only exists in these animals. A new rigid definition of true intrinsic cardiac regeneration is introduced and a set of testable hypotheses is proposed that can be addressed to reveal the proposed link between heart regeneration and cardiac metabolism ...
Anita Dittrich +5 more
wiley +1 more source
Brown adipose tissue in adult humans: A mini review
Journal of Clinical and Scientific Research, 2019 Adipose tissue is of two types: white adipose tissue (WAT) and brown adipose tissue (BAT). For a long time, it was considered that BAT is present only in hibernating animals and newborns, conferring them a protection from the cold environment.
V S Kiranmayi, K M Bhargav
doaj +1 more source
Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk
Journal of Cachexia, Sarcopenia and Muscle, Volume 10, Issue 6, Page 1210-1227, December 2019., 2019 Abstract Background Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα), which leads to cachexia in mice and is associated with cachexia in patients with CKD ...
Jiao Wu +7 more
wiley +1 more source
Mediators of Inflammation, Volume 2017, Issue 1, 2017., 2017 Obesity is marked by chronic, low‐grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages. White and brown adipocytes were characterized by transcriptional regulation of UCP-1, PGC1α, PGC1β, and CIDEA and their level of IL‐6 secretion.
Louisa Dowal +14 more
wiley +1 more source
Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis
PPAR Research, Volume 2016, Issue 1, 2016., 2016 The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life‐sustaining actions.
Borja Bandera Merchan +3 more
wiley +1 more source
Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue
BioMed Research International, Volume 2016, Issue 1, 2016., 2016 Nonshivering thermogenesis is the process of biological heat production in mammals and is primarily mediated by brown adipose tissue (BAT). Through ubiquitous expression of uncoupling protein 1 (Ucp1) on the mitochondrial inner membrane, BAT displays uncoupling of fuel combustion and ATP production in order to dissipate energy as heat.
Umesh D. Wankhade +4 more
wiley +1 more source
Activation and inhibition of sirtuins: From bench to bedside
Medicinal Research Reviews, Volume 45, Issue 2, Page 484-560, March 2025.Abstract The sirtuin family comprises seven NAD+‐dependent enzymes which catalyze protein lysine deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic stability and gene expression and control key processes, including energetic metabolism, cell cycle, differentiation, apoptosis, and aging.
Francesco Fiorentino +3 more
wiley +1 more source
Mitochondria in White, Brown, and Beige Adipocytes
Stem Cells International, Volume 2016, Issue 1, 2016., 2016 Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown‐like (bAT) adipose tissues.
Miroslava Cedikova +8 more
wiley +1 more source
Genetic Landscape of Obesity in Children: Research Advances and Prospects
Journal of Obesity, Volume 2025, Issue 1, 2025.Obesity is a chronic metabolic disease characterized by excessive accumulation or uneven distribution of fat in the body, which poses a serious threat to health. Obesity significantly increases the risk of developing сonditions such as type 2 diabetes, coronary heart disease, hypertension, obstructive sleep apnea, and some types of cancer.
Rita Khusainova +11 more
wiley +1 more source
Does Adipose Tissue Thermogenesis Play a Role in Metabolic Health?
Journal of Obesity, Volume 2013, Issue 1, 2013., 2013 The function ascribed to brown adipose tissue in humans has long been confined to thermoregulation in neonates, where this thermogenic capacity was thought lost with maturation. Recently, brown adipose tissue depots have been identified in adult humans.
Craig Porter +3 more
wiley +1 more source