Results 101 to 110 of about 8,581 (190)

AIE‐Active Cationic Tripyrrole Targeting Mitochondrial SDHAF1 for Acute Myeloid Leukemia Therapy

Aggregate, Volume 7, Issue 3, March 2026.
Cationic tripyrrole oligomers (Tri‐DPPy) selectively accumulate in mitochondria and suppress Complex II activity by binding to SDHAF1, thereby effectively eradicating AML cells both in vitro and in vivo. ABSTRACT Therapy‐resistant acute myeloid leukemia (AML) depends on mitochondrial oxidative phosphorylation (OXPHOS) to meet its energy demands, and ...
Wangxing Lin, Jun Cheng, Jingqin Chen, Weimin Xiao, Jiarui Li, Xiaoqi Wang, Meng Gao   +6 more
wiley   +1 more source

Entropy Generation Analysis due to Permeable Exponential Stretching in Boundary Layer Flows

Heat Transfer, Volume 55, Issue 2, Page 781-796, March 2026.
ABSTRACT Entropy generation represents the irreversible loss of useful energy in thermal–fluid systems, directly reducing efficiency in applications, such as microelectronics cooling, nanofluid‐based heat exchangers, and polymer processing. This study investigates entropy generation in a two‐phase viscoelastic nanofluid flow over a permeable ...
Khodani Sherrif Tshivhi, Maashutha Samuel Tshehla   +1 more
wiley   +1 more source

Collective photo-thermophoresis [PDF]

The stationary distributions of thermally interacting thermophoretic colloids under illumination are studied by mathematical analysis of mean field models. This work generalises the model of Golestanian by explicitly modelling the non-local and non-pairwise effect of shading on the collective dynamics.
openaire  

Network‐based allosteric analysis of galectin‐7: Key residues dictate functional communication and stability

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Allosteric modulation enables precise control of protein activity but remains difficult to harness for selective inhibitor design. Traditional high‐throughput screening for allosteric modulators is still costly and time‐consuming, underscoring the need for predictive computational approaches.
N. T. Hang Pham, Alex Paré, Myriam Létourneau, Marlène Fortier, David Chatenet, Yves St‐Pierre, Patrick Lagüe, Charles Calmettes, Nicolas Doucet   +8 more
wiley   +1 more source

Pseudolaric Acid B Combats Drug‐Resistant Candida albicans Infection via Dual‐Action Mechanisms of Direct Antifungals and Vaginal Microbiota Restoration

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
We propose a novel therapeutic approach against fungal infection: Pseudolaric acid B directly eradicates C. albicans via Erg11 inhibition and uniquely, restores vaginal microecological homeostasis by promoting probiotic lactobacilli, addressing both the pathogen and the dysbiotic environment.
Tianmeng Shao, Yunshan Zhang, Binqing Xue, Weihua Chu   +3 more
wiley   +1 more source

Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective

The FEBS Journal, Volume 293, Issue 6, Page 1801-1817, March 2026.
Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska, Anna Koczurowska, Marta Orlikowska, Maciej Nielipinski, Dominika Nielipinska, Bartosz Sekula   +5 more
wiley   +1 more source

Calmodulin‐Like Protein MfCML50 Interacts With Carveol Dehydrogenase in Medicago falcata to Regulate Cold Tolerance Through Mediating ROS Homeostasis

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1152-1165, March 2026.
ABSTRACT Low temperature triggers Ca2+ signalling and reprogramming of gene expression and metabolism in plants. However, how the Ca2+ signal is transduced to the downstream metabolic pathways remains unknown. The involvement of a cold‐induced calmodulin‐like protein, MfCML50, from Medicago falcata in regulation of cold tolerance was examined in the ...
Bohao Geng, Shuhan Yu, Qiguo Sun, Lei Yang, Qian Yang, Hailong Yang, Zhenfei Guo   +6 more
wiley   +1 more source

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

Direct‐to‐Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Crude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Ariane F. Hübner, Fabian Barthels
wiley   +1 more source

Thermophoresis in Aqueous Systems

Thermophoretic transport of colloidal particles in aqueous media, driven by temperature gradients, plays a crucial role in applications such as separation, enrichment, and biochemical sensing. The interplay between colloid size, surface chemistry, electrolyte composition, and background temperature govern thermophoretic behavior, though inconsistencies
openaire   +2 more sources