Results 71 to 80 of about 8,581 (190)

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier, Lukas Griesinger, Matthias Franzreb, Simon Kluters   +3 more
wiley   +1 more source

Exploring Soot Particle Concentration and Emissivity by Transient Thermocouples Measurements in Laminar Partially Premixed Coflow Flames

Energies, 2017
Soot formation in combustion represents a complex phenomenon that strongly depends on several factors such as pressure, temperature, fuel chemical composition, and the extent of premixing. The effect of partial premixing on soot formation is of relevance
Gianluigi De Falco, Giulia Moggia, Mariano Sirignano, Mario Commodo, Patrizia Minutolo, Andrea D’Anna   +5 more
doaj   +1 more source

Tailoring Thermophysical Properties and Multiscale Machine Learning Modeling of 2D Nanomaterial‐Infused Beeswax as a Green NePCM for Sustainable Thermal Management Systems

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This study develops eco‐friendly two‐dimensional nanoparticle‐enhanced phase change materials (2D NePCMs) using biodegradable beeswax infused with rGO, GO, and MXene nanoparticles. Experimental results demonstrated up to 21.9% enhancement in thermal conductivity with minimal latent heat loss, while machine learning models achieved >95% predictive ...
Abdullah Aziz, Shoaib Anwer, Eiyad Abu‐Nada, Anas Alazzam   +3 more
wiley   +1 more source

Effects of Concentrations of Water‐Based MgO Nanofluid on Heat Transfer Performance in Shell‐and‐Tube Heat Exchanger

Energy Science &Engineering, EarlyView.
This figure shows the variation of the total heat transfer coefficient of a shell and tube heat exchanger with different concentrations of water‐based MgO nanofluids at different inlet flow rates. The results indicate that the total heat transfer coefficient increases with increasing flow velocity, and at different volume fraction settings, the ...
Li Zhang, Yifan Cheng, Yang Liu, Yongju Zhang, Ziyun Chen   +4 more
wiley   +1 more source

Effect of Viscous Dissipation and Thermoporesis on the Flow Over an Exponentially Stretching Sheet

International Journal of Applied Mechanics and Engineering, 2019
This article analyses the influence of viscous dissipation and thermoporesis effects on the viscous fluid flow over a porous sheet stretching exponentially by applying convective boundary condition.
D. Srinivasacharya, P. Jagadeeshwar
doaj   +1 more source

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, EarlyView.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

The Next Frontier: Micro/Nanorobots Operating Inside the Living Body

SmartBot, EarlyView.
Micro/nanorobots, with their tiny size and controllable motion capabilities, can perform complex and precise tasks in micro‐spaces, thus showing broad application prospects in the biomedical field. This review systematically summarizes the core advantages of micro/nanorobots in real‐time in vivo imaging, targeted drug delivery, and active barrier ...
Ningbo Yu, Jie Yang, Zicheng Ni, Yuepeng Cai, Beatriz Jurado‐Sánchez, Renfeng Dong   +5 more
wiley   +1 more source

Polymer Thermophoresis by Mesoscale Simulations

Macromolecules
We employ mesoscopic simulations to study the thermophoretic motion of polymers in a solvent via multiparticle collision dynamics (MPCD). As the usual solvent-monomer collision rules employed in MPCD involving polymers fail to cause thermophoresis, we extend the technique by introducing explicit solvent-monomer interactions, while the solvent molecules
Sappl, Lisa, Likos, Christos N., Zöttl, Andreas   +2 more
openaire   +3 more sources

Chemical Reaction, Electrification, Brownian Motion and Thermophoresis Effects of Copper Nanoparticles on Nanofluid Flow with Skin Friction, Heat and Mass Transfer

East European Journal of Physics
This study investigates the effects of first-order chemical reaction, thermophoresis, electrification, and Brownian motion on  nanoparticles within a free convective nanofluid flow past a vertical plane surface, focusing on skin friction, heat and mass ...
Aditya Kumar Pati, Madan Mohan Rout, Runu Sahu, Iю Siva Ramakoti, Koustava Kumar Panda, Krushna Chandra Sethi   +5 more
doaj   +1 more source

Fluorescently Labeled Gradient Hydrogels Reveal Matrix‐Dependent Cell Responses to Substrate Stiffness

Small, EarlyView.
This work demonstrates a new thermophoretic strategy to fabricate fluorescently labeled stiffness gradient hydrogels, enabling contactless stiffness characterization. Fibroblasts cultured on gradient GelMA and Gellan gum hydrogels revealed distinct cell morphology and migration behavior.
Shin Wei Chong, Li Liu, Daryan Kempe, Yingqi Zhang, Kourosh Kalantar‐Zadeh, Marcela M. M. Bilek, Lining Arnold Ju, Maté Biro, Daniele Vigolo   +8 more
wiley   +1 more source