The secreted autotransporter toxin (Sat) does not act as a virulence factor in the probiotic Escherichia coli strain Nissle 1917 [PDF]
BACKGROUND: Escherichia coli Nissle 1917 (EcN) is a probiotic used in the treatment of intestinal diseases. Although it is considered safe, EcN is closely related to the uropathogenic E.
Aguilera Gil, Maria Laura+8 more
core +1 more source
'Add, stir and reduce': Yersinia spp. as model bacteria for pathogen evolution [PDF]
In the study of molecular microbiology and bacterial genetics, pathogenic species of the Yersinia genus have been pillars for research aimed at understanding how bacteria evolve into mammalian pathogens.
McNally, A+3 more
core +3 more sources
Measurement and Control of Single Nitrogen-Vacancy Center Spins above 600 K
We study the spin and orbital dynamics of single nitrogen-vacancy (NV) centers in diamond between room temperature and 700 K. We find that the ability to optically address and coherently control single spins above room temperature is limited by ...
Alkauskas, A.+5 more
core +2 more sources
Cerulenin inhibits unsaturated fatty acids synthesis in Bacillus subtilis by modifying the input signal of DesK thermosensor [PDF]
Bacillus subtilis responds to a sudden decrease in temperature by transiently inducing the expression of the des gene encoding for a lipid desaturase, D5-Des, which introduces a double bond into the acyl chain of preexisting membrane phospholipids.
Altabe, Silvia Graciela+4 more
core +1 more source
TRP Channels Entering the Structural Era [PDF]
Transient receptor potential (TRP) channels are important in many neuronal and non-neuronal physiological processes. The past 2 years have seen much progress in the use of structural biology techniques to elucidate molecular mechanisms of TRP channel ...
Gaudet, Rachelle
core +1 more source
Allosteric Activation of Bacterial Response Regulators: the Role of the Cognate Histidine Kinase Beyond Phosphorylation [PDF]
Response regulators are proteins that undergo transient phosphorylation, connecting specific signals to adaptive responses. Remarkably, the molecular mechanism of response regulator activation remains elusive, largely because of the scarcity of ...
Aguilar, Pablo Sebastián+10 more
core +4 more sources
Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8
Stimulation of μ-opioid receptors (OPRMs) brings powerful pain relief, but it also leads to the development of tolerance and addiction. Ensuing withdrawal in abstinent patients manifests itself with severe symptoms, including cold hyperalgesia, often preventing addicted patients from successfully completing the rehabilitation.
Roman Skryma+18 more
openaire +3 more sources
Thermoregulation of Meningococcal fHbp, an important virulence factor and vaccine antigen, is mediated by anti-ribosomal binding site sequences in the open reading frame [PDF]
During colonisation of the upper respiratory tract, bacteria are exposed to gradients of temperatures. Neisseria meningitidis is often present in the nasopharynx of healthy individuals, yet can occasionally cause severe disseminated disease.
Lavender, Hayle+4 more
core +3 more sources
Introduction: Ambient temperature-induced hypocotyl elongation in Arabidopsis seedlings is sensed by the epidermis-localized phytochrome B (phyB) and transduced into auxin biosynthesis via a basic helix-loop-helix transcription factor, phytochrome ...
Jin Jeon+15 more
doaj +1 more source
Temperature and heat flux measurements: Challenges for high temperature aerospace application [PDF]
The measurement of high temperatures and the influence of heat transfer data is not strictly a problem of either the high temperatures involved or the level of the heating rates to be measured at those high temperatures.
Neumann, Richard D.
core +1 more source