Results 181 to 190 of about 19,401 (288)

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

open access: yesAdvanced Science, Volume 13, Issue 34, 19 June 2026.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang   +15 more
wiley   +1 more source

Thiamine Deficiency and Neuroinflammation Are Important Contributors to Alcohol Use Disorder. [PDF]

open access: yesPathophysiology
Kalapatapu N   +5 more
europepmc   +1 more source

Impact of Rapid Exome Sequencing on Pediatric Patients With Cardiomyopathy and Acute Heart Failure

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1222-1230, June 2026.
ABSTRACT Few studies describe the impact of rapid exome sequencing (ES) on pediatric cardiomyopathy in urgent clinical settings. Here, we retrospectively report the impact of rapid singleton ES in pediatric patients presented with acute heart failure and isolated cardiomyopathy or myocarditis, between 2021 and 2023 at a single tertiary care center.
Tameemi Abdalla Moady   +10 more
wiley   +1 more source

Thiamine deficiency disease, dysautonomia, and high calorie malnutrition /

open access: yes
Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition explores thiamine and how its deficiency affects the functions of the brainstem and autonomic nervous system by way of metabolic changes at the level of the mitochondria.
Lonsdale, Derrickauthor.   +1 more
core  

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale   +5 more
wiley   +1 more source

Severe Restriction of Glucose Import Enhances Recombinant Protein Production in Escherichia coli

open access: yesBiotechnology Journal, Volume 21, Issue 6, June 2026.
Graphical Abstract and Lay Summary Producing recombinant proteins in Escherichia coli is often limited by the bacterium's tendency to consume glucose too rapidly. This excessive glucose uptake causes overflow metabolism, leading to the accumulation of acetate, a byproduct that can reduce cellular performance and protein production.
Juan Carlos Fragoso‐Jiménez   +5 more
wiley   +1 more source

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