Results 1 to 10 of about 16,562 (194)

Investigating Coenzyme Function of Thiamine Triphosphate Using Its Novel Hydrolysis-Resistant Analog and Transketolase [PDF]

Biomolecules
Thiamine (vitamin B1) and its phosphates are essential for almost all organisms. Thiamine diphosphate (ThDP) is the major intracellular derivative which is considered the only form functioning as a coenzyme.
Artem V. Artiukhov, Alexey V. Kazantsev, Olga N. Solovjeva, Vasily A. Aleshin   +3 more
doaj   +2 more sources

Dissecting the function of Atg1 complex in Dictyostelium autophagy reveals a connection with the pentose phosphate pathway enzyme transketolase [PDF]

Open Biology, 2015
The network of protein–protein interactions of the Dictyostelium discoideum autophagy pathway was investigated by yeast two-hybrid screening of the conserved autophagic proteins Atg1 and Atg8.
Ana Mesquita, Luis C. Tábara, Oscar Martinez-Costa, Natalia Santos-Rodrigo, Olivier Vincent, Ricardo Escalante   +5 more
doaj   +4 more sources

Novel transketolase inhibitor oroxylin A suppresses the non‐oxidative pentose phosphate pathway and hepatocellular carcinoma tumour growth in mice and patient‐derived organoids

Clinical and Translational Medicine, 2022
Background Transketolase (TKT), a key rate‐limiting enzyme in the non‐oxidative branch of the pentose phosphate pathway (PPP), provides more than 85% of the ribose required for de novo nucleotide biosynthesis and promotes the development of ...
Binghua Jiao, Zhenyu Cai
exaly   +2 more sources

Structural and Computational Insights into Transketolase-like 1 (TKTL-1): Distinction from TKT and Implications for Cancer Metabolism and Therapeutic Targeting [PDF]

Molecules
Transketolase-like protein 1 (TKTL-1) has been implicated in altered cancer metabolism, yet its structure and molecular function remain poorly understood.
Ahmad Junaid, Caleb J. Nwaogwugwu, Sameh H. Abdelwahed   +2 more
doaj   +2 more sources

Is transketolase-like protein, TKTL1, transketolase?

Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2013
Until recently it was assumed that the transketolase-like protein (TKTL1) detected in the tumor tissue, is catalytically active mutant form of human transketolase (hTKT). Human TKT shares 61% sequence identity with TKTL1. And the two proteins are 77% homologous at the amino acid level.
Olga N Solovjeva
exaly   +3 more sources

Anaerobic Faecalicatena spp. degrade sulfoquinovose via a bifurcated 6-deoxy-6-sulfofructose transketolase/transaldolase pathway to both C2- and C3-sulfonate intermediates [PDF]

Frontiers in Microbiology
Plant-produced sulfoquinovose (SQ, 6-deoxy-6-sulfoglucose) is one of the most abundant sulfur-containing compounds in nature and its bacterial degradation plays an important role in the biogeochemical sulfur and carbon cycles and in all habitats where SQ
Sabrina Borusak, Sabrina Borusak, Sabrina Borusak, Karin Denger, Till Dorendorf, Till Dorendorf, Corentin Fournier, Corentin Fournier, Harry Lerner, Harry Lerner, Olga Mayans, Olga Mayans, Dieter Spiteller, Dieter Spiteller, David Schleheck, David Schleheck, David Schleheck   +16 more
doaj   +2 more sources

Chaetocin, a Natural Inhibitor of Transketolase, Suppresses the Non-Oxidative Pentose Phosphate Pathway and Inhibits the Growth of Drug-Resistant Non-Small Cell Lung Cancer [PDF]

Antioxidants
Worldwide, lung cancer is the most common cause of cancer-related death, which is made worse by the development of drug resistance during treatment. It is urgent to develop new therapeutic methods and small molecule drugs for tumor resistance. Chaetocin,
Song Li, Zhanying Lu, Wenli Jiang, Yao Xu, Ran Chen, Jie Wang, Binghua Jiao, Xiaoling Lu   +7 more
doaj   +2 more sources

Extraordinary therapeutic effect of PSMA radioligand therapy in treatment-refractory progressive metastatic prostate cancer with the transketolase inhibitor benfo-oxythiamine as a radiosensitizer—A case report [PDF]

Frontiers in Medicine
Herein we report, for the first time, the therapeutic response of a prostate cancer patient with the thiamine antagonist benfo-oxythiamine (B-OT) added to prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (PRLT).
Carsten S. Kramer, Jingjing Zhang, Richard P. Baum   +2 more
doaj   +2 more sources

The Prevalence of Thiamine Deficiency and Associated Factors among Adult Population in Shiraz, Southern Iran [PDF]

International Journal of Nutrition Sciences, 2020
Background: Thiamine is an essential nutrient, and its deficiency is accompanied by nervous and cardiovascular disorders. This study aimed to assess the prevalence of thiamine deficiency and associated factors among adults in Shiraz, southern Iran ...
Zahra Hassanzadeh-Rostami, Fatemeh Mirjalili, Monireh Panbehkar, Zahra Fallah, Mohammad Khandouzi, Shiva Faghih   +5 more
doaj   +1 more source

A Correlative Study Between IVIM-DWI Parameters and the Expression Levels of Ang-2 and TKT in Hepatocellular Carcinoma

Frontiers in Oncology, 2021
BackgroundNoninvasive evaluation of the expression of angiopoietin-2 (Ang-2) and transketolase (TKT) in hepatocellular carcinoma (HCC) is of great significance for the clinical development of individualized treatment plans.
Jing Zheng, Xue Qin Gong, Yun Yun Tao, Ran Wang, Gang Yang, Jing Dong Li, Tian Ren, Zu Mao Li, Cui Yang, Wei Cheng Wang, Lin Yang, Xiao Ming Zhang   +11 more
doaj   +1 more source