Results 1 to 10 of about 10,904 (208)

The Catalytic Mechanism of Human Transketolase

ChemPhysChem, 2019
AbstractWe have computationally determined the catalytic mechanism of human transketolase (hTK) using a cluster model approach and density functional theory calculations. We were able to determine all the relevant structures, bringing solid evidences to the proposed experimental mechanism, and to add important detail to the structure of the transition ...
Fabiola E Medina, Maria J. Ramos, Tiziana Marino   +2 more
exaly   +3 more sources

No transketolase abnormalities in Wernicke-Korsakoff patients

Journal of the Neurological Sciences, 1991
Bert G Blijenberg
exaly  

Inhibition of transketolase by p-hydroxyphenylpyruvate

FEBS Letters, 1999
Olga N Solovjeva, German A Kochetov, G A Kochetov   +2 more
exaly  

Kinetic Studies of Mouse Brain Transketolase

Journal of Neurochemistry, 1982
Silvia Piacentini, John P Blass, J P Blass   +2 more
exaly  

A hitherto unknown transketolase—catalyzed reaction

Biochemical and Biophysical Research Communications, 2004
Olga N Solovjeva, German A Kochetov
exaly  

Two methods for determination of transketolase activity

Biochemistry (Moscow), 2006
Olga N Solovjeva, G A Kochetov
exaly  

Western blotting assay of transketolase concentration in human hemolysates

Analytical Biochemistry, 1988
Toshifumi Takeuchi, Kohsuke Nishino, K Nishino   +2 more
exaly  

Structure-Based Discovery and Synthesis of Potential Transketolase Inhibitors

Molecules, 2018
Transketolase (TKL) plays a key role in plant photosynthesis and has been predicted to be a potent herbicide target. Homology modeling and molecular dynamics simulation were used to construct a target protein model.
Zhijin Fan, Bin Zhao
exaly   +4 more sources

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme [PDF]

Open Biology, 2012
The transketolase (TKT) enzyme in Mycobacterium tuberculosis represents a novel drug target for tuberculosis treatment and has low homology with the orthologous human enzyme.
Elizabeth Fullam, Florence Pojer, Terese Bergfors, T. Alwyn Jones, Stewart T. Cole   +4 more
doaj   +3 more sources

Investigating Coenzyme Function of Thiamine Triphosphate Using Its Novel Hydrolysis-Resistant Analog and Transketolase [PDF]

Biomolecules
Thiamine (vitamin B1) and its phosphates are essential for almost all organisms. Thiamine diphosphate (ThDP) is the major intracellular derivative which is considered the only form functioning as a coenzyme.
Artem V. Artiukhov, Alexey V. Kazantsev, Olga N. Solovjeva, Vasily A. Aleshin   +3 more
doaj   +2 more sources