Results 11 to 20 of about 16,581 (212)

Reassessing Transketolase Assays: Methodological Considerations for Detecting Functional Thiamine Deficiency. [PDF]

Ann N Y Acad Sci
Transketolase (TKT) activity provides a functional measure of thiamine status by integrating cofactor availability, enzyme abundance, and catalytic capacity. TKT catalyzes thiamine diphosphate (TDP)‐dependent reactions in the nonoxidative pentose‐phosphate pathway and requires magnesium for optimal activity.
Edwards KA.
europepmc   +2 more sources

Revealing the functions of the transketolase enzyme isoforms in Rhodopseudomonas palustris using a systems biology approach. [PDF]

PLoS ONE, 2011
BACKGROUND: Rhodopseudomonas palustris (R. palustris) is a purple non-sulfur anoxygenic phototrophic bacterium that belongs to the class of proteobacteria. It is capable of absorbing atmospheric carbon dioxide and converting it to biomass via the process
Chia-Wei Hu, Ya-Ling Chang, Shiang Jiuun Chen, Ling-Long Kuo-Huang, James C Liao, Hsuan-Cheng Huang, Hsueh-Fen Juan   +6 more
doaj   +1 more source

Structure, kinetic characterization and subcellular localization of the two ribulose 5-phosphate epimerase isoenzymes from Trypanosoma cruzi [PDF]

, 2017
The enzyme of the pentose phosphate pathway (PPP) ribulose-5-phosphate-epimerase (RPE) is encoded by two genes present in the genome of Trypanosoma cruzi CL Brener clone: TcRPE1 and TcRPE2. Despite high sequence similarity at the amino acid residue level,
Cazzulo, Juan Jose, Delfino, Jose Maria, Gonzalez, Soledad Natalia, Maugeri, Dante, Valsecchi, Wanda Mariela   +4 more
core   +14 more sources

Interrogating the Role of the Two Distinct Fructose-Bisphosphate Aldolases of Bacillus methanolicus by Site-Directed Mutagenesis of Key Amino Acids and Gene Repression by CRISPR Interference

Frontiers in Microbiology, 2021
The Gram-positive Bacillus methanolicus shows plasmid-dependent methylotrophy. This facultative ribulose monophosphate (RuMP) cycle methylotroph possesses two fructose bisphosphate aldolases (FBA) with distinct kinetic properties.
Kerstin Schultenkämper, Desirée D. Gütle, Marina Gil López, Laura B. Keller, Lin Zhang, Oliver Einsle, Jean-Pierre Jacquot, Volker F. Wendisch   +7 more
doaj   +1 more source

A δ38 deletion variant of human transketolase as a model of transketolase-like protein 1 exhibits no enzymatic activity. [PDF]

PLoS ONE, 2012
Besides transketolase (TKT), a thiamin-dependent enzyme of the pentose phosphate pathway, the human genome encodes for two closely related transketolase-like proteins, which share a high sequence identity with TKT.
Stefan Schneider, Stefan Lüdtke, Kathrin Schröder-Tittmann, Cindy Wechsler, Danilo Meyer, Kai Tittmann   +5 more
doaj   +1 more source

Carbohydrate Metabolism Parameters of Adult Glial Neoplasms According to Immunohistochemical Profile

Biomedicines, 2022
This research aimed to investigate the interrelationship of carbohydrate metabolism parameters and immunohistochemical characteristics of glial tumors. Tumor tissue, peritumoral area, and adjacent noncancerous tissue fragments of 20 patients with gliomas
Larisa Obukhova, Olga Nikiforova, Claudia Kontorshchikova, Igor Medyanik, Natalya Orlinskaya, Artem Grishin, Michael Kontorshchikov, Natalya Shchelchkova   +7 more
doaj   +1 more source

Enhancing erythritol production from crude glycerol in a wild-type Yarrowia lipolytica by metabolic engineering

Frontiers in Microbiology, 2022
Background: Erythritol is a zero-calorie sweetener that is widely used in the food, pharmaceutical, and medical industries. Crude glycerol is the main by-product of biodiesel, and the effective utilization of crude glycerol will help to improve biodiesel
Shuling Yang, Xuewei Pan, Qiang Wang, Qinglan Lv, Xian Zhang, Rongzhen Zhang, Zhiming Rao   +6 more
doaj   +1 more source

The significance of solute carrier group of genes in the pathogenesis and treatment of diabetic microvascular complications

Journal of Education, Health and Sport, 2020
Aim- To study the impact of the solute carrier group of genes on the mechanisms involved in hyperglycemia induced tissue damage and its implication on the treatment of diabetic microvascular complications.Introduction – the estimated figure of people ...
K. Singh, T. Yuzvenko
doaj   +1 more source

Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer

Frontiers in Medicine, 2022
Colorectal cancer (CRC) remains a heavy health burden worldwide. Transketolase (TKT) is a crucial enzyme in the non-oxidative phase of the Pentose Phosphate Pathway (PPP), and is up-regulated in multiple cancer types.
Linhao Zhang, Linhao Zhang, Zhiyin Huang, Qiuyu Cai, Qiuyu Cai, Chong Zhao, Chong Zhao, Yang Xiao, Yang Xiao, Xin Quan, Xin Quan, Chengwei Tang, Chengwei Tang, Jinhang Gao, Jinhang Gao   +14 more
doaj   +1 more source

Emerging role of the pentose phosphate pathway in hepatocellular carcinoma [PDF]

, 2017
In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined.
Columbano, Amedeo, Kowalik, MARTA ANNA, Perra, Andrea   +2 more
core   +2 more sources