Results 11 to 20 of about 8,762 (179)

Kinetic parameter prediction using neural networks identifies limitations to C4 photosynthesis [PDF]

New Phytologist, Volume 251, Issue 3, Page 1578-1594, August 2026.
Schematic overview of the generation of artificial training data and training of neural networks in C4TUNE. Summary Kinetic models of photosynthesis enable time‐resolved predictions of traits related to this key process and provide the means to identify factors limiting photosynthesis.
Philipp Wendering, John Ferguson, Rudan Xu, Johannes Kromdijk, Zoran Nikoloski   +4 more
wiley   +2 more sources

Investigating Coenzyme Function of Thiamine Triphosphate Using Its Novel Hydrolysis-Resistant Analog and Transketolase [PDF]

Biomolecules
Thiamine (vitamin B1) and its phosphates are essential for almost all organisms. Thiamine diphosphate (ThDP) is the major intracellular derivative which is considered the only form functioning as a coenzyme.
Artem V. Artiukhov, Alexey V. Kazantsev, Olga N. Solovjeva, Vasily A. Aleshin   +3 more
doaj   +2 more sources

Structural and Computational Insights into Transketolase-like 1 (TKTL-1): Distinction from TKT and Implications for Cancer Metabolism and Therapeutic Targeting [PDF]

Molecules
Transketolase-like protein 1 (TKTL-1) has been implicated in altered cancer metabolism, yet its structure and molecular function remain poorly understood.
Ahmad Junaid, Caleb J. Nwaogwugwu, Sameh H. Abdelwahed   +2 more
doaj   +2 more sources

Anaerobic Faecalicatena spp. degrade sulfoquinovose via a bifurcated 6-deoxy-6-sulfofructose transketolase/transaldolase pathway to both C2- and C3-sulfonate intermediates [PDF]

Frontiers in Microbiology
Plant-produced sulfoquinovose (SQ, 6-deoxy-6-sulfoglucose) is one of the most abundant sulfur-containing compounds in nature and its bacterial degradation plays an important role in the biogeochemical sulfur and carbon cycles and in all habitats where SQ
Sabrina Borusak, Sabrina Borusak, Sabrina Borusak, Karin Denger, Till Dorendorf, Till Dorendorf, Corentin Fournier, Corentin Fournier, Harry Lerner, Harry Lerner, Olga Mayans, Olga Mayans, Dieter Spiteller, Dieter Spiteller, David Schleheck, David Schleheck, David Schleheck   +16 more
doaj   +2 more sources

Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer

Frontiers in Medicine, 2022
Colorectal cancer (CRC) remains a heavy health burden worldwide. Transketolase (TKT) is a crucial enzyme in the non-oxidative phase of the Pentose Phosphate Pathway (PPP), and is up-regulated in multiple cancer types.
Linhao Zhang, Linhao Zhang, Zhiyin Huang, Qiuyu Cai, Qiuyu Cai, Chong Zhao, Chong Zhao, Yang Xiao, Yang Xiao, Xin Quan, Xin Quan, Chengwei Tang, Chengwei Tang, Jinhang Gao, Jinhang Gao   +14 more
doaj   +1 more source

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme [PDF]

Open Biology, 2012
The transketolase (TKT) enzyme in Mycobacterium tuberculosis represents a novel drug target for tuberculosis treatment and has low homology with the orthologous human enzyme.
Elizabeth Fullam, Florence Pojer, Terese Bergfors, T. Alwyn Jones, Stewart T. Cole   +4 more
doaj   +1 more source

Interrogating the Role of the Two Distinct Fructose-Bisphosphate Aldolases of Bacillus methanolicus by Site-Directed Mutagenesis of Key Amino Acids and Gene Repression by CRISPR Interference

Frontiers in Microbiology, 2021
The Gram-positive Bacillus methanolicus shows plasmid-dependent methylotrophy. This facultative ribulose monophosphate (RuMP) cycle methylotroph possesses two fructose bisphosphate aldolases (FBA) with distinct kinetic properties.
Kerstin Schultenkämper, Desirée D. Gütle, Marina Gil López, Laura B. Keller, Lin Zhang, Oliver Einsle, Jean-Pierre Jacquot, Volker F. Wendisch   +7 more
doaj   +1 more source

Overexpression of transketolase-like gene 1 is associated with cell proliferation in uterine cervix cancer

Journal of Experimental & Clinical Cancer Research, 2009
Background Tumor cells need large energy and nucleic acids to proliferate and grow. For most of their energy needs, cancer cells depend more on glycolysis. For most of their nucleic acids needs, cancer cells depend more on the nonoxidative pathway of the
Chen Hui, Yue Jian-Xin, Yang Shou-Hua, Ding Hui, Zhao Rong-Wei, Zhang Song   +5 more
doaj   +1 more source

Novel transketolase inhibitor oroxylin A suppresses the non‐oxidative pentose phosphate pathway and hepatocellular carcinoma tumour growth in mice and patient‐derived organoids

Clinical and Translational Medicine, 2022
Background Transketolase (TKT), a key rate‐limiting enzyme in the non‐oxidative branch of the pentose phosphate pathway (PPP), provides more than 85% of the ribose required for de novo nucleotide biosynthesis and promotes the development of ...
Dan Jia, Chunliang Liu, Zhenyu Zhu, Yan Cao, Wen Wen, Zhanying Hong, Yue Liu, Erdong Liu, Long Chen, Chun Chen, Yanqiu Gu, Binghua Jiao, Yifeng Chai, Hong‐yang Wang, Jing Fu, Xiaofei Chen   +15 more
doaj   +1 more source

Reduced Thiamine Availability and Hyperglycemia Impair Thiamine Transport in Renal Glomerular Cells through Modulation of Thiamine Transporter 2

Biomedicines, 2021
Thiamine helps transketolase in removing toxic metabolites, counteracting high glucose-induced damage in microvascular cells, and progression of diabetic retinopathy/nephropathy in diabetic animals.
Aurora Mazzeo, Federica Barutta, Linda Bellucci, Marina Trento, Gabriella Gruden, Massimo Porta, Elena Beltramo   +6 more
doaj   +1 more source