Overexpression of transketolase-like gene 1 is associated with cell proliferation in uterine cervix cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2009 Background Tumor cells need large energy and nucleic acids to proliferate and grow. For most of their energy needs, cancer cells depend more on glycolysis. For most of their nucleic acids needs, cancer cells depend more on the nonoxidative pathway of the
Chen Hui +5 more
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Structural and Computational Insights into Transketolase-like 1 (TKTL-1): Distinction from TKT and Implications for Cancer Metabolism and Therapeutic Targeting [PDF]
MoleculesTransketolase-like protein 1 (TKTL-1) has been implicated in altered cancer metabolism, yet its structure and molecular function remain poorly understood.
Ahmad Junaid +2 more
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Transketolase in Trypanosoma brucei
Molecular and Biochemical Parasitology, 2011 A single copy gene, encoding a protein highly similar to transketolase from other systems, was identified in the Trypanosoma brucei genome. The gene was expressed in E. coli and the purified protein demonstrated transketolase activity with K(m) values of 0.2mM and 0.8mM respectively for xylulose 5-phosphate and ribose 5-phosphate.
Stoffel, Sabine A. +7 more
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A δ38 deletion variant of human transketolase as a model of transketolase-like protein 1 exhibits no enzymatic activity. [PDF]
PLoS ONE, 2012 Besides transketolase (TKT), a thiamin-dependent enzyme of the pentose phosphate pathway, the human genome encodes for two closely related transketolase-like proteins, which share a high sequence identity with TKT.
Stefan Schneider +5 more
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Diphenyl urea derivatives as inhibitors of transketolase: a structure-based virtual screening. [PDF]
PLoS ONE, 2012 Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs. Here, we report new human transketolase inhibitors, based on the phenyl urea scaffold,
Cristian Obiol-Pardo +3 more
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Heterologous expression of human transketolase [PDF]
The International Journal of Biochemistry & Cell Biology, 1998 Transketolase belongs to the family of thiamin diphosphate dependent enzymes. The aim of this study was to establish a bacterial expression system for human transketolase in order to investigate the functional characteristics of mammalian transketolases. The level of recombinant human enzyme expressed in Escherichia coli was modest.
Schenk, Gerhard +2 more
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The Prevalence of Thiamine Deficiency and Associated Factors among Adult Population in Shiraz, Southern Iran [PDF]
International Journal of Nutrition Sciences, 2020 Background: Thiamine is an essential nutrient, and its deficiency is accompanied by nervous and cardiovascular disorders. This study aimed to assess the prevalence of thiamine deficiency and associated factors among adults in Shiraz, southern Iran ...
Zahra Hassanzadeh-Rostami +5 more
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Frontiers in Oncology, 2021 BackgroundNoninvasive evaluation of the expression of angiopoietin-2 (Ang-2) and transketolase (TKT) in hepatocellular carcinoma (HCC) is of great significance for the clinical development of individualized treatment plans.
Jing Zheng +11 more
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Revealing the functions of the transketolase enzyme isoforms in Rhodopseudomonas palustris using a systems biology approach. [PDF]
PLoS ONE, 2011 BACKGROUND: Rhodopseudomonas palustris (R. palustris) is a purple non-sulfur anoxygenic phototrophic bacterium that belongs to the class of proteobacteria. It is capable of absorbing atmospheric carbon dioxide and converting it to biomass via the process
Chia-Wei Hu +6 more
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Dissecting the function of Atg1 complex in Dictyostelium autophagy reveals a connection with the pentose phosphate pathway enzyme transketolase [PDF]
Open Biology, 2015 The network of protein–protein interactions of the Dictyostelium discoideum autophagy pathway was investigated by yeast two-hybrid screening of the conserved autophagic proteins Atg1 and Atg8.
Ana Mesquita +5 more
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