Results 31 to 40 of about 10,904 (208)

The significance of solute carrier group of genes in the pathogenesis and treatment of diabetic microvascular complications

open access: yesJournal of Education, Health and Sport, 2020
Aim- To study the impact of the solute carrier group of genes on the mechanisms involved in hyperglycemia induced tissue damage and its implication on the treatment of diabetic microvascular complications.Introduction – the estimated figure of people ...
K. Singh, T. Yuzvenko
doaj   +1 more source

A ‘Split-Gene’ Transketolase From the Hyper-Thermophilic Bacterium Carboxydothermus hydrogenoformans: Structure and Biochemical Characterization

open access: yesFrontiers in Microbiology, 2020
A novel transketolase has been reconstituted from two separate polypeptide chains encoded by a ‘split-gene’ identified in the genome of the hyperthermophilic bacterium, Carboxydothermus hydrogenoformans.
Paul James   +5 more
doaj   +1 more source

New Assays for Transketolase

open access: yesBioscience, Biotechnology, and Biochemistry, 1993
Given the importance of transketolase, TK (EC 2.2.1.1) for both pharmacological studies and synthetic purposes, the need for a simple and inexpensive assay is patent. We describe here a simple and inexpensive TK assay using the unphosphorylated ketoses L-erythrulose, 4-deoxy-L-erythrulose, and 4-deoxy-D,L-erythrulose as donor substrates instead of D ...
Hecquet, Laurence   +2 more
openaire   +1 more source

The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases [PDF]

open access: yesBMC Structural Biology, 2019
Three transketolase genes have been identified in the human genome to date: transketolase (TKT), transketolase-like 1 (TKTL1) and transketolase-like 2 (TKTL2). Altered TKT functionality is strongly implicated in the development of diabetes and various cancers, thus offering possible therapeutic utility.
Gaurang P. Deshpande   +2 more
openaire   +3 more sources

Discovery of Novel Transketolase Epitopes and the Development of IgG-Based Tuberculosis Serodiagnostics

open access: yesMicrobiology Spectrum, 2023
Despite advances in rapid molecular techniques for tuberculosis (TB) diagnostics, there is an unmet need for a point-of-care, nonsputum-based test. Previously, through a T7 phage antigen display platform and immunoscreening, we identified that the serum ...
Jaya Talreja   +4 more
doaj   +1 more source

Recombinant protein expression in Pichia pastoris strains with an engineered methanol utilization pathway

open access: yesMicrobial Cell Factories, 2012
Βackground The methylotrophic yeast Pichia pastoris has become an important host organism for recombinant protein production and is able to use methanol as a sole carbon source.
Krainer Florian W   +5 more
doaj   +1 more source

Protein Markers Related to Non-halal Slaughtering Process of Rat as Mammal Animal’s Model Detected Using Mass Spectrometry Proteome Analysis

open access: yesIndonesian Journal of Chemistry, 2022
Meat produced from non-halal slaughter is forbidden for Moslems. The slaughter methods contribute to the physiological response of animals expressed as different proteome profile.
Alvina Nur Aini   +2 more
doaj   +1 more source

Evidence for a transketolase-mediated metabolic checkpoint governing biotrophic growth in rice cells by the blast fungus Magnaporthe oryzae. [PDF]

open access: yesPLoS Pathogens, 2014
The blast fungus Magnaporthe oryzae threatens global food security through the widespread destruction of cultivated rice. Foliar infection requires a specialized cell called an appressorium that generates turgor to force a thin penetration hypha through ...
Jessie Fernandez   +2 more
doaj   +1 more source

Properties and functions of the thiamin diphosphate dependent enzyme transketolase [PDF]

open access: yes, 1991
This review highlights recent research on the properties and functions of the enzyme transketolase, which requires thiamin diphosphate and a divalent metal ion for its activity.
Schenk, Gerhard, Duggleby, Ronald
core   +1 more source

The role of transketolase in the immunotherapy and prognosis of hepatocellular carcinoma: a multi-omics approach

open access: yesFrontiers in Immunology
ObjectiveTo explore the role of transketolase (TKT) in the immunotherapy and prognosis of hepatocellular carcinoma (HCC).Materials and methodsTKT expression across various cancers and its associations with tumor immunity and prognosis were analyzed using
Xuan-Yu Gu   +6 more
doaj   +1 more source

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