Results 21 to 30 of about 10,904 (208)

Carbohydrate Metabolism Parameters of Adult Glial Neoplasms According to Immunohistochemical Profile

Biomedicines, 2022
This research aimed to investigate the interrelationship of carbohydrate metabolism parameters and immunohistochemical characteristics of glial tumors. Tumor tissue, peritumoral area, and adjacent noncancerous tissue fragments of 20 patients with gliomas
Larisa Obukhova, Olga Nikiforova, Claudia Kontorshchikova, Igor Medyanik, Natalya Orlinskaya, Artem Grishin, Michael Kontorshchikov, Natalya Shchelchkova   +7 more
doaj   +1 more source

Enhancing erythritol production from crude glycerol in a wild-type Yarrowia lipolytica by metabolic engineering

Frontiers in Microbiology, 2022
Background: Erythritol is a zero-calorie sweetener that is widely used in the food, pharmaceutical, and medical industries. Crude glycerol is the main by-product of biodiesel, and the effective utilization of crude glycerol will help to improve biodiesel
Shuling Yang, Xuewei Pan, Qiang Wang, Qinglan Lv, Xian Zhang, Rongzhen Zhang, Zhiming Rao   +6 more
doaj   +1 more source

Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer

Frontiers in Medicine, 2022
Colorectal cancer (CRC) remains a heavy health burden worldwide. Transketolase (TKT) is a crucial enzyme in the non-oxidative phase of the Pentose Phosphate Pathway (PPP), and is up-regulated in multiple cancer types.
Linhao Zhang, Linhao Zhang, Zhiyin Huang, Qiuyu Cai, Qiuyu Cai, Chong Zhao, Chong Zhao, Yang Xiao, Yang Xiao, Xin Quan, Xin Quan, Chengwei Tang, Chengwei Tang, Jinhang Gao, Jinhang Gao   +14 more
doaj   +1 more source

Kinetic parameter prediction using neural networks identifies limitations to C₄ photosynthesis. [PDF]

New Phytol
Schematic overview of the generation of artificial training data and training of neural networks in C4TUNE. Summary Kinetic models of photosynthesis enable time‐resolved predictions of traits related to this key process and provide the means to identify factors limiting photosynthesis.
Wendering P, Ferguson J, Xu R, Kromdijk J, Nikoloski Z.   +4 more
europepmc   +2 more sources

Interrogating the Role of the Two Distinct Fructose-Bisphosphate Aldolases of Bacillus methanolicus by Site-Directed Mutagenesis of Key Amino Acids and Gene Repression by CRISPR Interference

Frontiers in Microbiology, 2021
The Gram-positive Bacillus methanolicus shows plasmid-dependent methylotrophy. This facultative ribulose monophosphate (RuMP) cycle methylotroph possesses two fructose bisphosphate aldolases (FBA) with distinct kinetic properties.
Kerstin Schultenkämper, Desirée D. Gütle, Marina Gil López, Laura B. Keller, Lin Zhang, Oliver Einsle, Jean-Pierre Jacquot, Volker F. Wendisch   +7 more
doaj   +1 more source

Mechanistic Studies of Escherichia Coli Transketolase

, 2008
The enzyme transketolase is found in nature as part of the Pentose Phosphate Pathway to rearrange large sugar phosphates. It also is an important enzyme for carboncarbon bond formation for industrial biocatalysis.
Mathew Paul Martin (21819599)
core   +5 more sources

Novel transketolase inhibitor oroxylin A suppresses the non‐oxidative pentose phosphate pathway and hepatocellular carcinoma tumour growth in mice and patient‐derived organoids

Clinical and Translational Medicine, 2022
Background Transketolase (TKT), a key rate‐limiting enzyme in the non‐oxidative branch of the pentose phosphate pathway (PPP), provides more than 85% of the ribose required for de novo nucleotide biosynthesis and promotes the development of ...
Dan Jia, Chunliang Liu, Zhenyu Zhu, Yan Cao, Wen Wen, Zhanying Hong, Yue Liu, Erdong Liu, Long Chen, Chun Chen, Yanqiu Gu, Binghua Jiao, Yifeng Chai, Hong‐yang Wang, Jing Fu, Xiaofei Chen   +15 more
doaj   +1 more source

Reduced Thiamine Availability and Hyperglycemia Impair Thiamine Transport in Renal Glomerular Cells through Modulation of Thiamine Transporter 2

Biomedicines, 2021
Thiamine helps transketolase in removing toxic metabolites, counteracting high glucose-induced damage in microvascular cells, and progression of diabetic retinopathy/nephropathy in diabetic animals.
Aurora Mazzeo, Federica Barutta, Linda Bellucci, Marina Trento, Gabriella Gruden, Massimo Porta, Elena Beltramo   +6 more
doaj   +1 more source

Acidosis Activates the Nrf2 Pathway in Renal Proximal Tubule-Derived Cells through a Crosstalk with Renal Fibroblasts

Antioxidants, 2023
Crosstalk of renal epithelial cells with interstitial fibroblasts plays an important role in kidney pathophysiology. A previous study showed that crosstalk between renal epithelial cells and renal fibroblasts protects against acidosis-induced damage.
Marie-Christin Schulz, Virginie Dubourg, Alexander Nolze, Michael Kopf, Gerald Schwerdt, Michael Gekle   +5 more
doaj   +1 more source

Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells

, 2016
Background: The metabolism of cancer cells is often reprogrammed by dysregulation of metabolic enzymes. Transketolase-like 1 (TKTL1) is a homodimeric transketolase linking the pentose-phosphate pathway with the glycolytic pathway.
P-H Lo (12526261), M Davalos-Salas (12526270), Andreas Behren (9477650), AC Chueh (12526264), M Anaka (9888308), Jonathan Cebon (9483446), Aparna Jayachandran (3460802), R Molania (12526267), Marzena Walkiewicz (436361), P Prithviraj (9888305)   +9 more
core   +2 more sources