Results 21 to 30 of about 8,654 (179)
The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases [PDF]
BMC Structural Biology, 2019 Three transketolase genes have been identified in the human genome to date: transketolase (TKT), transketolase-like 1 (TKTL1) and transketolase-like 2 (TKTL2). Altered TKT functionality is strongly implicated in the development of diabetes and various cancers, thus offering possible therapeutic utility.
Gaurang P. Deshpande +2 more
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Frontiers in Microbiology, 2020 A novel transketolase has been reconstituted from two separate polypeptide chains encoded by a ‘split-gene’ identified in the genome of the hyperthermophilic bacterium, Carboxydothermus hydrogenoformans.
Paul James +5 more
doaj +1 more source
Diphenyl urea derivatives as inhibitors of transketolase: a structure-based virtual screening. [PDF]
PLoS ONE, 2012 Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs. Here, we report new human transketolase inhibitors, based on the phenyl urea scaffold,
Cristian Obiol-Pardo +3 more
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Microbiology Spectrum, 2023 Despite advances in rapid molecular techniques for tuberculosis (TB) diagnostics, there is an unmet need for a point-of-care, nonsputum-based test. Previously, through a T7 phage antigen display platform and immunoscreening, we identified that the serum ...
Jaya Talreja +4 more
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Microbial Cell Factories, 2012 Βackground The methylotrophic yeast Pichia pastoris has become an important host organism for recombinant protein production and is able to use methanol as a sole carbon source.
Krainer Florian W +5 more
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Indonesian Journal of Chemistry, 2022 Meat produced from non-halal slaughter is forbidden for Moslems. The slaughter methods contribute to the physiological response of animals expressed as different proteome profile.
Alvina Nur Aini +2 more
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Evidence for a transketolase-mediated metabolic checkpoint governing biotrophic growth in rice cells by the blast fungus Magnaporthe oryzae. [PDF]
PLoS Pathogens, 2014 The blast fungus Magnaporthe oryzae threatens global food security through the widespread destruction of cultivated rice. Foliar infection requires a specialized cell called an appressorium that generates turgor to force a thin penetration hypha through ...
Jessie Fernandez +2 more
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Heterologous expression of human transketolase [PDF]
The International Journal of Biochemistry & Cell Biology, 1998 Transketolase belongs to the family of thiamin diphosphate dependent enzymes. The aim of this study was to establish a bacterial expression system for human transketolase in order to investigate the functional characteristics of mammalian transketolases. The level of recombinant human enzyme expressed in Escherichia coli was modest.
Schenk, Gerhard +2 more
openaire +6 more sources
Frontiers in ImmunologyObjectiveTo explore the role of transketolase (TKT) in the immunotherapy and prognosis of hepatocellular carcinoma (HCC).Materials and methodsTKT expression across various cancers and its associations with tumor immunity and prognosis were analyzed using
Xuan-Yu Gu +6 more
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Mìžnarodnij Endokrinologìčnij Žurnal, 2019 The review article presents an analysis of the literature on the effect of thiamine and its derivatives on the metabolism in cells and its role in the pathogenesis of complications of diabetes mellitus.
K. Singh, T. Yuzvenko, D. Kogut
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