Results 21 to 30 of about 8,762 (179)
Antioxidants, 2023 Crosstalk of renal epithelial cells with interstitial fibroblasts plays an important role in kidney pathophysiology. A previous study showed that crosstalk between renal epithelial cells and renal fibroblasts protects against acidosis-induced damage.
Marie-Christin Schulz +5 more
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Journal of Education, Health and Sport, 2020 Aim- To study the impact of the solute carrier group of genes on the mechanisms involved in hyperglycemia induced tissue damage and its implication on the treatment of diabetic microvascular complications.Introduction – the estimated figure of people ...
K. Singh, T. Yuzvenko
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Frontiers in Microbiology, 2020 A novel transketolase has been reconstituted from two separate polypeptide chains encoded by a ‘split-gene’ identified in the genome of the hyperthermophilic bacterium, Carboxydothermus hydrogenoformans.
Paul James +5 more
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Diphenyl urea derivatives as inhibitors of transketolase: a structure-based virtual screening. [PDF]
PLoS ONE, 2012 Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs. Here, we report new human transketolase inhibitors, based on the phenyl urea scaffold,
Cristian Obiol-Pardo +3 more
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Bioscience, Biotechnology, and Biochemistry, 1993 Given the importance of transketolase, TK (EC 2.2.1.1) for both pharmacological studies and synthetic purposes, the need for a simple and inexpensive assay is patent. We describe here a simple and inexpensive TK assay using the unphosphorylated ketoses L-erythrulose, 4-deoxy-L-erythrulose, and 4-deoxy-D,L-erythrulose as donor substrates instead of D ...
Hecquet, Laurence +2 more
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The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases [PDF]
BMC Structural Biology, 2019 Three transketolase genes have been identified in the human genome to date: transketolase (TKT), transketolase-like 1 (TKTL1) and transketolase-like 2 (TKTL2). Altered TKT functionality is strongly implicated in the development of diabetes and various cancers, thus offering possible therapeutic utility.
Gaurang P. Deshpande +2 more
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Microbiology Spectrum, 2023 Despite advances in rapid molecular techniques for tuberculosis (TB) diagnostics, there is an unmet need for a point-of-care, nonsputum-based test. Previously, through a T7 phage antigen display platform and immunoscreening, we identified that the serum ...
Jaya Talreja +4 more
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Microbial Cell Factories, 2012 Βackground The methylotrophic yeast Pichia pastoris has become an important host organism for recombinant protein production and is able to use methanol as a sole carbon source.
Krainer Florian W +5 more
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Indonesian Journal of Chemistry, 2022 Meat produced from non-halal slaughter is forbidden for Moslems. The slaughter methods contribute to the physiological response of animals expressed as different proteome profile.
Alvina Nur Aini +2 more
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Evidence for a transketolase-mediated metabolic checkpoint governing biotrophic growth in rice cells by the blast fungus Magnaporthe oryzae. [PDF]
PLoS Pathogens, 2014 The blast fungus Magnaporthe oryzae threatens global food security through the widespread destruction of cultivated rice. Foliar infection requires a specialized cell called an appressorium that generates turgor to force a thin penetration hypha through ...
Jessie Fernandez +2 more
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