Results 21 to 30 of about 10,076 (212)
Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer
Frontiers in Medicine, 2022 Colorectal cancer (CRC) remains a heavy health burden worldwide. Transketolase (TKT) is a crucial enzyme in the non-oxidative phase of the Pentose Phosphate Pathway (PPP), and is up-regulated in multiple cancer types.
Linhao Zhang +14 more
doaj +1 more source
Frontiers in Microbiology, 2020 A novel transketolase has been reconstituted from two separate polypeptide chains encoded by a ‘split-gene’ identified in the genome of the hyperthermophilic bacterium, Carboxydothermus hydrogenoformans.
Paul James +5 more
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Biomedicines, 2021 Thiamine helps transketolase in removing toxic metabolites, counteracting high glucose-induced damage in microvascular cells, and progression of diabetic retinopathy/nephropathy in diabetic animals.
Aurora Mazzeo +6 more
doaj +1 more source
Antioxidants, 2023 Crosstalk of renal epithelial cells with interstitial fibroblasts plays an important role in kidney pathophysiology. A previous study showed that crosstalk between renal epithelial cells and renal fibroblasts protects against acidosis-induced damage.
Marie-Christin Schulz +5 more
doaj +1 more source
Angewandte Chemie, EarlyView.This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis +2 more
wiley +2 more sources
Mìžnarodnij Endokrinologìčnij Žurnal, 2019 The review article presents an analysis of the literature on the effect of thiamine and its derivatives on the metabolism in cells and its role in the pathogenesis of complications of diabetes mellitus.
K. Singh, T. Yuzvenko, D. Kogut
doaj +1 more source
Bioscience, Biotechnology, and Biochemistry, 1993 Given the importance of transketolase, TK (EC 2.2.1.1) for both pharmacological studies and synthetic purposes, the need for a simple and inexpensive assay is patent. We describe here a simple and inexpensive TK assay using the unphosphorylated ketoses L-erythrulose, 4-deoxy-L-erythrulose, and 4-deoxy-D,L-erythrulose as donor substrates instead of D ...
Hecquet, Laurence +2 more
openaire +1 more source
The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases [PDF]
BMC Structural Biology, 2019 Three transketolase genes have been identified in the human genome to date: transketolase (TKT), transketolase-like 1 (TKTL1) and transketolase-like 2 (TKTL2). Altered TKT functionality is strongly implicated in the development of diabetes and various cancers, thus offering possible therapeutic utility.
Gaurang P. Deshpande +2 more
openaire +3 more sources
Diphenyl urea derivatives as inhibitors of transketolase: a structure-based virtual screening. [PDF]
PLoS ONE, 2012 Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs. Here, we report new human transketolase inhibitors, based on the phenyl urea scaffold,
Cristian Obiol-Pardo +3 more
doaj +1 more source
Transketolase Is Identified as a Target of Herbicidal Substance α-Terthienyl by Proteomics
Toxins, 2018 α-terthienyl is a natural phytotoxin isolated originally from Flaveria bidentis (L.) Kuntze. The bioassay presented here shows the strong herbicidal activity of α-terthienyl on Digitaria sanguinalis, Arabidopsis thaliana and Chlamydomonas reinhardtii ...
Bin Zhao +4 more
doaj +1 more source