The effects of thiamine pyrophosphate on ethanol induced optic nerve damage [PDF]
BMC Pharmacology and Toxicology, 2019 Background We aimed to determine the protective effects of thiamine pyrophosphate on ethanol induced optic neuropathy in an experimental model. Methods The rats were assigned into 4 groups, with 6 rats in each group as follows: healthy controls (HC group)
Turgay Ucak +7 more
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Functional analysis of thiamine pyrophosphate-responsive riboswitches in human bacterial pathogens of the ESKAPE group using a dual-luciferase reporter gene assay [PDF]
Journal of BacteriologyThiamine pyrophosphate (TPP)-responsive riboswitches are genetic elements in bacteria that regulate the expression of genes coding for proteins involved in the biosynthesis and transport of thiamine (vitamin B1). Following uptake, cytoplasmic thiamine is
Anna Hübenthal +3 more
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Thiamine and Thiamine Pyrophosphate as Non-Competitive Inhibitors of Acetylcholinesterase—Experimental and Theoretical Investigations [PDF]
MoleculesVitamin B1 (thiamine) plays an important role in human metabolism. It is essential for the proper growth and development of the body and has a positive effect on the functioning of the digestive, cardiovascular, and nervous systems.
Łukasz Szeleszczuk +2 more
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Utility of Whole Blood Thiamine Pyrophosphate Evaluation in <i>TPK1</i>-Related Diseases. [PDF]
J Clin Med, 2019 TPK1 mutations are a rare, but potentially treatable, cause of thiamine deficiency. Diagnosis is challenging given the phenotypic overlap that exists with other metabolic and neurological disorders.
Bugiardini E +11 more
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The Role of Thiamine Pyrophosphate in Prevention of Cisplatin Ototoxicity in an Animal Model [PDF]
The Scientific World Journal, 2013 Objective. The aim of this study was to evaluate the effectiveness of thiamine pyrophosphate against cisplatin-induced ototoxicity in guinea pigs. Materials and Methods. Healthy guinea pigs (n=18) were randomly divided into three groups.
Ozan Kuduban +4 more
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The Protective Effect of Thiamine and Thiamine Pyrophosphate Against Linezolid-Induced Oxidative Liver Damage and Lactic Acidosis in Rats [PDF]
AntioxidantsLinezolid, an antimicrobial agent, has been linked to lactic acidosis, oxidative stress, and liver damage. Oxidative stress is considered to play a key role in this damage.
Bahar Isik +6 more
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Novel TPP-riboswitch activators bypass metabolic enzyme dependency [PDF]
Frontiers in Chemistry, 2014 Riboswitches are conserved regions within mRNA molecules that bind specific metabolites and regulate gene expression. TPP-riboswitches, which respond to thiamine pyrophosphate (TPP), are involved in the regulation of thiamine metabolism in numerous ...
Günter eMayer +3 more
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Optimizing thiamine pyrophosphate metabolism enhances crop yield and quality [PDF]
Nature CommunicationsGlobal food security requires sustainable strategies to improve crop yield and nutrition. Although thiamine pyrophosphate (TPP), the active form of vitamin B1, plays a central role in energy metabolism, redox homeostasis, and carbon assimilation, its ...
Yun Luo +14 more
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Comparative Study on the Protective Effect of Thiamine and Thiamine Pyrophosphate Against Hydroxychloroquine-Induced Cardiomyopathy in Rats [PDF]
LifeBackground: Hydroxychloroquine (HCQ), widely used in autoimmune and inflammatory diseases, has been associated with cardiotoxicity driven by oxidative, mitochondrial, and metabolic disturbances.
Izzet Emir +8 more
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Identification and characterisation of thiamine pyrophosphate (TPP) riboswitch in Elaeis guineensis. [PDF]
PLoS ONE, 2020 The oil palm (Elaeis guineensis) is an important crop in Malaysia but its productivity is hampered by various biotic and abiotic stresses. Recent studies suggest the importance of signalling molecules in plants in coping against stresses, which includes ...
Atiqah Subki +4 more
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