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Biochimica et Biophysica Acta (BBA) - General Subjects, 2021
Thiamine deficiency (TD) has a number of features in common with the neurodegenerative diseases development and close relationship between TD and oxidative stress (OS) has been repeatedly reported in the literature. The aim of this study is to understand how alimentary TD, accompanied by OS, affects the expression and level of two thiamine metabolism ...
Pavlova, O +5 more
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Thiamine deficiency (TD) has a number of features in common with the neurodegenerative diseases development and close relationship between TD and oxidative stress (OS) has been repeatedly reported in the literature. The aim of this study is to understand how alimentary TD, accompanied by OS, affects the expression and level of two thiamine metabolism ...
Pavlova, O +5 more
openaire +3 more sources
Drug and Chemical Toxicology, 2013
This study investigated the effect of thiamine pyrophosphate on oxidative damage associated with cardiotoxicity caused by cisplatin (CIS), an antineoplastic agent, in rats, and compared this with thiamine. Animals used in the study were divided into four groups of 6 rats each.
TURAN, MEHMET İBRAHİM +3 more
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This study investigated the effect of thiamine pyrophosphate on oxidative damage associated with cardiotoxicity caused by cisplatin (CIS), an antineoplastic agent, in rats, and compared this with thiamine. Animals used in the study were divided into four groups of 6 rats each.
TURAN, MEHMET İBRAHİM +3 more
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Reduction of Ferricyanide by Thiamine or Thiamine Pyrophosphate
Biochemical and Biophysical Research Communications, 1996The colorimetric assay for the activity of pyruvate dehydrogenase (EC 1.2.4.1) developed by Itokawa is based on a coupled reduction of ferricyanide and the formation of Prussian blue (Brian Research 94, 475-484). In this assay system, we found that the coenzyme, thiamine pyrophosphate, itself reduced ferricyanide independent of both the enzyme and the ...
G, Li, M E, Cook, W, Wu
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An efficient enzymatic synthesis of thiamin pyrophosphate
Bioorganic & Medicinal Chemistry Letters, 2003Thiamin pyrophosphate was synthesized in 71% yield, on a multi-milligram scale, using overexpressed thiazole kinase, pyrimidine kinase, thiamin phosphate synthase, and thiamin phosphate kinase. This provides a facile route to isotopically labeled thiamin pyrophosphate from its readily available pyrimidine and thiazole precursors.
Jonathan S, Melnick +4 more
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Cleavage of thiamine pyrophosphate by sulfite in saccharomyces cerevisiae
Zeitschrift f�r Lebensmittel-Untersuchung und -Forschung, 1985Sulfite at low concentrations (≧ 1 mM caused a cleavage of thiamine in vitro depending upon time, pH value, and temperature. Thiamine monophosphate (TMP) and thiamine pyrophosphate (TPP) were also cleaved, but the reaction rates were slower. For the separation and determination of thiamine, TMP and TPP in yeast high-performance liquid chromatography ...
Lenz, A.-G., Holzer, H.
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The binding of thiamine pyrophosphate with transketolase in equilibrium conditions
Biochemical and Biophysical Research Communications, 1975Abstract The binding between thiamine pyrophosphate and transketolase, purified from baker's yeast, in equilibrium conditions has been studied. In the presence of Ca2+, the enzyme molecule has been shown to possess two binding sites for the coenzyme, whose dissociation constants are 3.2 × 10−8 and 2.5 × 10−7M; besides, there are site(s) where the ...
G A, Kochetov +2 more
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The role of bound thiamine pyrophosphate in the synthesis of thiamine triphosphate in rat liver
Biochimica et Biophysica Acta (BBA) - Enzymology, 1977Thiamine pyrophosphate-ATP phosphoryltransferase, the enzyme that catalyzes the synthesis of thiamine triphosphate, has been found in the supernatant fraction of rat liver. The substrate for the enzyme is endogenous, bound thiamine pyrophosphate, since the addition of exogenous thiamine pyrophosphate had no effect.
P, Ruenwongsa, J R, Cooper
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Thiamin status of the elderly: dietary intake and thiamin pyrophosphate response.
Journal of the American College of Nutrition, 1994The present study was undertaken to investigate the relationship between thiamin intake and its biochemical status in 60 free-living (30 male, 30 female) elderly subjects (> or = 65 years).Dietary intake was estimated using a 3-nonconsecutive-day food record.
H K, Nichols, T K, Basu
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[27] Thiamine pyrophosphate-agarose and the purification of a thiamine-binding protein
1974Publisher Summary Escherichia coli contains a thiamine-binding protein that is thought to be involved in the transport of thiamine through the cell membrane. Because of the very small amount of the thiamine-binding protein in the periplasmic space of the cells, a more effective purification procedure than the conventional method was required to ...
Atsuko Matsuura +2 more
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Organic & Biomolecular Chemistry, 2008
Novel triazole-based pyrophosphate analogues of thiamine pyrophosphate (TPP) have been synthesised and tested for inhibition of pyruvate decarboxylase (PDC) from Zymomonas mobilis. The thiazolium ring of thiamine was replaced by a triazole in an efficient two-step procedure.
Karl M, Erixon +2 more
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Novel triazole-based pyrophosphate analogues of thiamine pyrophosphate (TPP) have been synthesised and tested for inhibition of pyruvate decarboxylase (PDC) from Zymomonas mobilis. The thiazolium ring of thiamine was replaced by a triazole in an efficient two-step procedure.
Karl M, Erixon +2 more
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