Results 1 to 10 of about 6,543 (123)

Thiamine and Thiamine Pyrophosphate as Non-Competitive Inhibitors of Acetylcholinesterase—Experimental and Theoretical Investigations [PDF]

Molecules
Vitamin B1 (thiamine) plays an important role in human metabolism. It is essential for the proper growth and development of the body and has a positive effect on the functioning of the digestive, cardiovascular, and nervous systems.
Łukasz Szeleszczuk, Błaźej Grodner
exaly   +4 more sources

The effects of thiamine pyrophosphate on ethanol induced optic nerve damage [PDF]

BMC Pharmacology and Toxicology, 2019
Background We aimed to determine the protective effects of thiamine pyrophosphate on ethanol induced optic neuropathy in an experimental model. Methods The rats were assigned into 4 groups, with 6 rats in each group as follows: healthy controls (HC group)
Turgay Ucak, Yucel Karakurt, Gamze Tasli, Ferda Keskin Cimen, Erel Icel, Nezahat Kurt, Ibrahim Ahiskali, Halis Süleyman   +7 more
doaj   +2 more sources

Functional analysis of thiamine pyrophosphate-responsive riboswitches in human bacterial pathogens of the ESKAPE group using a dual-luciferase reporter gene assay [PDF]

Journal of Bacteriology
Thiamine pyrophosphate (TPP)-responsive riboswitches are genetic elements in bacteria that regulate the expression of genes coding for proteins involved in the biosynthesis and transport of thiamine (vitamin B1). Following uptake, cytoplasmic thiamine is
Anna Hübenthal, Vipul Panchal, Ruth Brenk, Matthias Mack   +3 more
doaj   +2 more sources

Clioquinol inactivates thiamine pyrophosphate by increasing cellular oxidative stress [PDF]

Redox Biology
Clioquinol (CQ), a prescribed oral antibiotic, was withdrawn from use following its association with the incidence of subacute myelo-optic neuropathy (SMON) in Japan. The neurotoxicity associated with CQ may be linked to thiamine deficiency.
Zheyu Fan, Xianghui Yan, Qiaoqiao Zheng, Ziting Zhu, Boyi Song, Xiao Feng, Siyu Pan, Chunyi Lv, Ping Shi   +8 more
doaj   +2 more sources

The Role of Thiamine Pyrophosphate in Prevention of Cisplatin Ototoxicity in an Animal Model [PDF]

The Scientific World Journal, 2013
Objective. The aim of this study was to evaluate the effectiveness of thiamine pyrophosphate against cisplatin-induced ototoxicity in guinea pigs. Materials and Methods. Healthy guinea pigs (n=18) were randomly divided into three groups.
Ozan Kuduban, Cuneyt Kucur, Ebru Sener, Halis Suleyman, Fatih Akcay   +4 more
doaj   +2 more sources

Comparative Study on the Protective Effect of Thiamine and Thiamine Pyrophosphate Against Hydroxychloroquine-Induced Cardiomyopathy in Rats [PDF]

Life
Background: Hydroxychloroquine (HCQ), widely used in autoimmune and inflammatory diseases, has been associated with cardiotoxicity driven by oxidative, mitochondrial, and metabolic disturbances.
Izzet Emir, Bulent Yavuzer, Bahadir Suleyman, Cengiz Sarigul, Ali Sefa Mendil, Esra Tuba Sezgin, Durdu Altuner, Cebrail Gursul, Halis Suleyman   +8 more
doaj   +2 more sources

Optimizing thiamine pyrophosphate metabolism enhances crop yield and quality [PDF]

Nature Communications
Global food security requires sustainable strategies to improve crop yield and nutrition. Although thiamine pyrophosphate (TPP), the active form of vitamin B1, plays a central role in energy metabolism, redox homeostasis, and carbon assimilation, its ...
Yun Luo, Yu Liu, Jie Liu, Xiaojing Liu, Huinan Li, Yu Wu, Junli Zhao, Yuebin Wang, Wenjie Fang, Liumei Jian, Lin Zhuo, Wenqiang Li, Junpeng Zhan, Alisdair R. Fernie, Jianbing Yan   +14 more
doaj   +2 more sources

Analysis of the Use of Carrots, Cauliflower and Broccoli Waste Materials as a Matrix for Thiamine [PDF]

Foods
The investigation aimed to use selected waste plant materials as thiamine matrices for fortification purposes. Thiamine hydrochloride (TCh) and thiamine pyrophosphate (TP) constituted the sources of thiamine.
Krystyna Eleonora Szymandera-Buszka, Agata Jankowska, Paweł Juszczak   +2 more
doaj   +2 more sources

The Protective Effect of Thiamine and Thiamine Pyrophosphate Against Linezolid-Induced Oxidative Liver Damage and Lactic Acidosis in Rats [PDF]

Antioxidants
Linezolid, an antimicrobial agent, has been linked to lactic acidosis, oxidative stress, and liver damage. Oxidative stress is considered to play a key role in this damage.
Bahar Isik, Irem Ates, Nurinisa Yucel, Bahadir Suleyman, Ali Sefa Mendil, Esra Tuba Sezgin, Halis Suleyman   +6 more
doaj   +2 more sources

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Savvidou A, Reilly C, Sofou K, Ygberg S, Eklund EA, Naess K, Darin N.   +6 more
europepmc   +2 more sources