Enterohemorrhagic Escherichia coli infection inhibits colonic thiamin pyrophosphate uptake via transcriptional mechanism. [PDF]
Colonocytes possess a specific carrier-mediated uptake process for the microbiota-generated thiamin (vitamin B1) pyrophosphate (TPP) that involves the TPP transporter (TPPT; product of the SLC44A4 gene).
Anandam, Kasin Yadunandam +4 more
core +1 more source
Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon (Salmo salar) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat (Sprattus sprattus) and herring ...
Marja Keinänen +7 more
doaj +1 more source
Protective Role of Thiamine Pyrophosphate Against Erlotinib-Induced Oxidative and Inflammatory Damage in Rat Optic Nerve. [PDF]
Karatas E +7 more
europepmc +2 more sources
Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults. [PDF]
Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others ...
Adams +154 more
core +2 more sources
The Effect of Thiamine Concentration on the Antioxidative Activity Indices in Tea Extracts
The aim of the study was to determine correlations between the concentration of thiamine in systems and indicators of the antioxidative activity of ethanol tea extracts in the presence of soybean oil.
Justyna Piechocka +4 more
doaj +1 more source
Thermodynamic examination of the pyrophosphate sensor helix in the thiamine pyrophosphate riboswitch [PDF]
Riboswitches are functional mRNA that control gene expression. Thiamine pyrophosphate (TPP) binds tothi-box riboswitch RNA and allosterically inhibits genes that code for proteins involved in the biosynthesis and transport of thiamine. Thiamine binding to the pyrimidine sensor helix and pyrophosphate binding to the pyrophosphate sensor helix cause ...
Stephanie, Furniss, Neena, Grover
openaire +2 more sources
Background/Aims: Thiamine-responsive megaloblastic anemia syndrome is a rare autosomal recessive disorder resulting from mutations in SLC19A2, and is mainly characterized by megaloblastic anemia, diabetes, and progressive sensorineural hearing loss ...
Xiaoying Xian +7 more
doaj +1 more source
The vitamin B1 metabolism of Staphylococcus aureus is controlled at enzymatic and transcriptional levels. [PDF]
Vitamin B1 is in its active form thiamine pyrophosphate (TPP), an essential cofactor for several key enzymes in the carbohydrate metabolism. Mammals must salvage this crucial nutrient from their diet in order to complement the deficiency of de novo ...
Ingrid B Müller +7 more
doaj +1 more source
Toward eradication of B-vitamin deficiencies : considerations for crop biofortification [PDF]
'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world ...
Strobbe, Simon +1 more
core +3 more sources
Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica. [PDF]
Phosphoribosylamine (PRA) is an intermediate in the biosynthetic pathway that is common to thiamine and purines. Glutamine phosphoribosyl pyrophosphate (PRPP) amidotransferase is the product of the purF gene in Salmonella enterica and catalyzes the ...
Mark J Koenigsknecht +3 more
doaj +1 more source

