Results 41 to 50 of about 6,590 (170)

Folding of the Thiamine Pyrophosphate (TPP) Riboswitch [PDF]

Biophysical Journal, 2010
TPP riboswitches regulate the expression of thiamine-synthesis (thi) genes through a variety of mechanisms, all of which involve binding of TPP to a structured aptamer formed in the untranslated region (UTR) of a thi mRNA. We used a high-resolution, single-molecule optical trapping assay to characterize mechanically the folding of the TPP riboswitch ...
Anthony, Peter C., Perez, Christian F., García-García, Cuauhtémoc, Block, Steven M.   +3 more
openaire   +1 more source

Scientific Opinion on the substantiation of a health claim related to thiamine and carbohydrate and energy‐yielding metabolism pursuant to Article 14 of Regulation (EC) No 1924/2006

EFSA Journal, 2010
Following an application from IDACE submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific ...
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
doaj   +1 more source

Synthesis of Mixed Dinucleotides by Mechanochemistry

Molecules, 2022
We report the synthesis of vitamin B1, B2, and B3 derived nucleotides and dinucleotides generated either through mechanochemical or solution phase chemistry.
Faisal Hayat, Mikhail V. Makarov, Luxene Belfleur, Marie E. Migaud   +3 more
doaj   +1 more source

Displacement of thiamine pyrophosphate from swollen mitochondria

Biochimica et Biophysica Acta, 1957
The distribution of TPP in cytoplasm fractions of rat liver is studied. When the homogenate was prepared with 0.25M sucrose, about 300% of TPP was present in mitochondria. When the homogenization medium was distilled water, the amount of TPP present in this fraction was markedly decreased, while that present in the supernatant fluid was increased ...
Dianzani, M.U., Dianzani Mor, M.A.
openaire   +3 more sources

Examination of the Effects of Thiamine and Thiamine Pyrophosphate on Doxorubicin-Induced Experimental Cardiotoxicity

Journal of Cardiovascular Pharmacology and Therapeutics, 2014
Background and Purpose: To investigate the effect of thiamine and thiamine pyrophosphate on doxorubicin-induced cardiotoxicity biochemically and histopathologically and to examine whether doxorubicin cardiotoxicity is related to the conversion of thiamine into thiamine pyrophosphate and inhibition of thiamine ...
Suleyman, Halis, Akcay, Fatih, Sener, Ebru, POLAT, Beyzagül   +3 more
openaire   +3 more sources

Phosphonomethyl (Thio)Phosphonamidite Reagents for the Construction of Phosphonylmethyl Phosphono(Di)Thioate Mono‐ and Diesters

Chemistry – A European Journal, EarlyView.
A set of new phosphonomethyl (thio)phosphonamidite reagents is introduced to generate unprecedented pyrophosphate mimetics. The versatile P(III)‐P(V) reagents allow for the construction of various pyrophosphate isosteres, and the applicability of the chemistry is illustrated in the assembly of a diverse set of stabilized CDP‐glycerol and CDP‐ribitol ...
Pascal Balić, Roy Steneker, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov   +4 more
wiley   +1 more source

Thiamine Diphosphate‐Dependent Biocatalysis in the 21st Century

Chemistry – A European Journal, EarlyView.
This account summarizes the major discoveries and recent advances, highlighting the biocatalytic abilities, mechanistic studies, and feature‐based classification that are shaping emerging perspectives on thiamine diphosphate (ThDP)‐dependent catalysis.
Lucrezia Lanza, Daniela Bjarnesen, Michael Müller   +2 more
wiley   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

Role of thiamine supplementation in the treatment of patients with heart failure: A double-blind randomized controlled trial

Heart India, 2019
Introduction: The role of thiamine supplementation in heart failure (HF) patients has shown conflicting results and has not been adequately studied.
Shamim Iqbal, Aamir Rashid, Irfan Bhat, Jahangir Rashid, Imran Hafeez, Ajaz Lone, Khurshid Iqbal, Iqbal Dar   +7 more
doaj   +1 more source

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source