Results 41 to 50 of about 75,666 (233)

Single-molecule FRET studies on the cotranscriptional folding of a thiamine pyrophosphate riboswitch. [PDF]

Proc Natl Acad Sci U S A, 2018
Uhm H, Kang W, Ha KS, Kang C, Hohng S.
europepmc   +2 more sources

Triazole-Based Thiamine Analogues as Inhibitors of Thiamine Pyrophosphate-Dependent Enzymes: 1,3-Dicarboxylate for Metal Binding [PDF]

ACS Omega
Terence C. S. Ho, Alex H. Y. Chan, Finian J. Leeper   +2 more
doaj   +2 more sources

Redirection of the Reaction Specificity of a Thermophilic Acetolactate Synthase toward Acetaldehyde Formation. [PDF]

PLoS ONE, 2016
Acetolactate synthase and pyruvate decarboxylase are thiamine pyrophosphate-dependent enzymes that convert pyruvate into acetolactate and acetaldehyde, respectively.
Maria Cheng, Hayato Yoshiyasu, Kenji Okano, Hisao Ohtake, Kohsuke Honda   +4 more
doaj   +1 more source

Presence of thiamine pyrophosphate in mammalian peroxisomes [PDF]

BMC Biochemistry, 2007
Abstract Background Thiamine pyrophosphate (TPP) is a cofactor for 2-hydroxyacyl-CoA lyase 1 (HACL1), a peroxisomal enzyme essential for the α-oxidation of phytanic acid and 2-hydroxy straight chain fatty acids. So far, HACL1 is the only known peroxisomal TPP-dependent enzyme in mammals.
Fraccascia, Patrizia, Sniekers, Mieke, Casteels, Minne, Van Veldhoven, Paul P   +3 more
openaire   +2 more sources

Thermodynamic examination of the pyrophosphate sensor helix in the thiamine pyrophosphate riboswitch [PDF]

RNA, 2011
Riboswitches are functional mRNA that control gene expression. Thiamine pyrophosphate (TPP) binds tothi-box riboswitch RNA and allosterically inhibits genes that code for proteins involved in the biosynthesis and transport of thiamine. Thiamine binding to the pyrimidine sensor helix and pyrophosphate binding to the pyrophosphate sensor helix cause ...
Stephanie, Furniss, Neena, Grover
openaire   +2 more sources

Letter to the Editor: Gastrointestinal Pseudo-Obstruction Is Not an Uncommon Phenotypic Manifestation of POLG1 Variants-Authors' Reply. [PDF]

Eur J Neurol
European Journal of Neurology, Volume 33, Issue 6, June 2026.
Capece G, Manara R, Salviati L, Viscomi C, Bello L, Pegoraro E.   +5 more
europepmc   +2 more sources

High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice. [PDF]

PLoS ONE, 2017
SLC19A3 deficiency, also called thiamine metabolism dysfunction syndrome-2 (THMD2; OMIM 607483), is an autosomal recessive neurodegenerative disorder caused by mutations in SLC19A3, the gene encoding thiamine transporter 2.
Kaoru Suzuki, Kenichiro Yamada, Yayoi Fukuhara, Ai Tsuji, Katsumi Shibata, Nobuaki Wakamatsu   +5 more
doaj   +1 more source

Partial Decay of Thiamine Signal Transduction Pathway Alters Growth Properties of Candida glabrata. [PDF]

PLoS ONE, 2016
The phosphorylated form of thiamine (Vitamin B1), thiamine pyrophosphate (TPP) is essential for the metabolism of amino acids and carbohydrates in all organisms. Plants and microorganisms, such as yeast, synthesize thiamine de novo whereas animals do not.
Christine L Iosue, Nicholas Attanasio, Noor F Shaik, Erin M Neal, Sarah G Leone, Brian J Cali, Michael T Peel, Amanda M Grannas, Dennis D Wykoff   +8 more
doaj   +1 more source

Mechanismus der enzymatischen Freisetzung von Acetaldehyd aus “aktivem Acetaldehyd” (α-hydroxyaethyl-2-thiaminpyrophosphat) [PDF]

, 1961
1. 1.Die Freisetzung von Acetaldehyd aus “Aktivem Acetaldehyd” mit gereinigter Apopyruvatdecarboxylase aus Bierhefe wird durch. Thiaminpyrophosphat gehemmt.
Breslow, Carlson, Goedde, H Holzer, Happold, Holzer, Holzer, Holzer, Holzer, Horner, Krampitz, P Scriba, Pardee, S Schneider   +13 more
core   +1 more source

The Involvement of Thiamine Uptake in the Virulence of Edwardsiella piscicida

Pathogens, 2022
Edwardsiella piscicida is a pathogenic bacterium, which can infect a number of fish species and cause a disease termed edwardsiellosis, threatening global fish farming with high prevalence and mortality.
Xin Liu, Xinhui Wang, Boguang Sun, Li Sun   +3 more
doaj   +1 more source