Results 61 to 70 of about 6,593 (171)

Mild symptomatic Wernicke’s Encephalopathy: a case report

Journal of Health Sciences, 2018
Wernicke’s encephalopathy (WE) is an acute, neuropsychiatric syndrome which results from a deficiency in vitamin B1 (thiamine), which in its biologically active form, thiamine pyrophosphate, is an essential coenzyme in several biochemical pathways in the
Maria Sofia Cotelli, Patrizia Civelli, Marinella Turla   +2 more
doaj   +1 more source

Development and Genetic Monitoring of a Putatively Thiamine Deficiency Complex Tolerant Atlantic Salmon Broodstock

Ecology and Evolution, Volume 16, Issue 8, August 2026.
We introduce efforts to develop a potentially thiamine deficiency complex (TDC) tolerant Atlantic salmon broodstock via selective breeding, as well as control broodstock with higher genetic diversity (and no selection). Additionally, we develop the genetic monitoring tools (novel genetic marker panel, parentage‐based tagging) to monitor the demographic
Kurt C. Heim, Avril M. Harder, Laurie A. Earley, Paul Boynton, Shane Hanlon, Jacques Rinchard, Kevin Kelsey, Stacey A. Nerkowski, Nathan R. Campbell, William R. Ardren   +9 more
wiley   +1 more source

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a common chronic liver disease. This study investigates the anti‐MASLD effects of dietary prebiotic stachyose (STA) on disease progression identifying Butyricimonas virosa as a key ...
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
doaj   +1 more source

Novel TPP-riboswitch activators bypass metabolic enzyme dependency

Frontiers in Chemistry, 2014
Riboswitches are conserved regions within mRNA molecules that bind specific metabolites and regulate gene expression. TPP-riboswitches, which respond to thiamine pyrophosphate (TPP), are involved in the regulation of thiamine metabolism in numerous ...
Günter eMayer, Christina eLünse, Colin eSuckling, Fraser eScott   +3 more
doaj   +1 more source

Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity

Epilepsia, Volume 67, Issue 8, Page 4078-4094, August 2026.
Abstract Objective We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Annika Breuer, Chiara A. Hummel, Tobias Baumgartner, Juliane L. Berns, Afaf Milad Said, Isabel Bünger, Susanne Schoch, Gábor Zsurka, Harald Prüss, Wolfram S. Kunz, Rainer Surges, Albert J. Becker, Julika Pitsch   +12 more
wiley   +1 more source

A common structural motif in thiamin pyrophosphate‐binding enzymes

FEBS Letters, 1989
The amino acid sequences of a wide range of enzymes that utilize thiamin pyrophosphate (TPP) as cofactor have been compared. A common sequence motif approximately 30 residues in length was detected, beginning with the highly conserved sequence ‐GDG‐ and concluding with the highly conserved sequence ‐NN‐. Secondary structure predictions suggest that the
Hawkins, Christopher F., Borges, Adolfo, Perham, Richard N.   +2 more
openaire   +2 more sources

Atorvastatin Reduces Alcohol‐Related Cardiac and Liver Tissue Damage, Oxidative Stress, Inflammation, Apoptosis, and Thiol‐Disulfide Imbalance in Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Atorvastatin (40 mg/kg) inhibited fibrosis, hypertrophy, apoptosis, inflammation, and oxidative stress caused by alcohol consumption. It may contribute to the regulation of mitochondrial function and thiol/disulfide balance by limiting alcohol‐related heart and liver damage.
Cumaali Demirtas, Şahhan Kılıç, Mert Babaoğlu, Süha Asal, Elif Gökçe Tenekeci, Hakan Beyaztaş, Eray Metin Guler, Salime Pelin Erguven, Kubra Sevgin   +8 more
wiley   +1 more source

Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica

Microbial Cell, 2017
In Salmonella enterica, aminoimidazole carboxamide ribotide (AICAR) is a purine biosynthetic intermediate and a substrate of the AICAR transformylase/IMP cyclohydrolase (PurH) enzyme.
Jannell V. Bazurto, Stephen P. Dearth, Eric D. Tague, Shawn R. Campagna, Diana M. Downs   +4 more
doaj   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Evolutionary history and recombination in the mitochondrial carrier SLC25 superfamily analyzed by similarities in the exon and transmembrane α‐helix sequences

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Mitochondrial carriers (MCs), which constitute a superfamily also called the solute carrier family 25 (SLC25), are characterized by conserved signature motif sequences and a six‐transmembrane α‐helical transporter domain. They transport a wide variety of substrates ranging from protons, inorganic ions, citric acid cycle intermediates, and ...
Magnus Monné, Daniela Valeria Miniero, Rosa Calvello, Antonia Cianciulli, Luigi Palmieri, Ferdinando Palmieri   +5 more
wiley   +1 more source