Results 51 to 60 of about 6,593 (171)

Role of thiamine supplementation in the treatment of patients with heart failure: A double-blind randomized controlled trial

Heart India, 2019
Introduction: The role of thiamine supplementation in heart failure (HF) patients has shown conflicting results and has not been adequately studied.
Shamim Iqbal, Aamir Rashid, Irfan Bhat, Jahangir Rashid, Imran Hafeez, Ajaz Lone, Khurshid Iqbal, Iqbal Dar   +7 more
doaj   +1 more source

A TAF10‐ERF109 Transcriptional Module Directs Flavonoid‐Based Stress Resilience and Yield Enhancement in Foxtail Millet and Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT To ensure sustainable agricultural production under escalating environmental constraints such as drought and salinity, innovative strategies are urgently needed. Here, we reveal in foxtail millet (Setaria italica) that transcription factors TAF10 and ERF109 form a functional complex which co‐activates the expression of key flavonoid ...
Meng Zhang, Kangwei Wang, Jiayin Fan, Yue Zheng, Qi Zhang, Haoyang Du, Shenghui Xiao, Jinguang Huang, Kang Yan, Shizhong Zhang, Qiang He, Guanqing Jia, Chengchao Zheng, Xianmin Diao, Guodong Yang, Changai Wu   +15 more
wiley   +1 more source

Evolution‐Inspired Engineering of Diterpene Biosynthesis via Chloroplast Genome Modification

Plant Biotechnology Journal, EarlyView.
ABSTRACT Terpenes constitute the largest and most structurally diverse class of plant secondary metabolites, with critical roles in plant‐environment interactions and broad industrial applications. Although nuclear genome engineering of terpene pathways has been extensively explored, chloroplast genome engineering remains largely undeveloped, with most
Alessandro Occhialini, Xinlu Chen, Samantha A. Miller, Mohammad Majdi, Ivette A. Fuentes Quispe, Gabriella King, Feng Chen   +6 more
wiley   +1 more source

Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells

Scientific Reports, 2017
Accumulating evidences suggest that p53 is a key coordinator of cellular events triggered by oxidative stress often associated with the impairment in thiamine metabolism and its functions.
Sergiy Chornyy, Yulia Parkhomenko, Nataliya Chorna   +2 more
doaj   +1 more source

THIAMINE SUPPLEMENT THERAPY IMPROVES EJECTION FRACTION VALUE IN STAGE II HEART FAILURE PATIENTS

Folia Medica Indonesiana, 2017
Thiamine, also called vitamin B1, is a water soluble vitamin that is involved in the formation of ATP in cells. The active metabolite of thiamine is a co-enzyme thiamine pyrophosphate (TPP) that plays an active role in carbohydrate metabolism and the ...
Rafi Jikrona, Suharjono Suharjono, Abraham Ahmad   +2 more
doaj   +1 more source

Diphenyl urea derivatives as inhibitors of transketolase: a structure-based virtual screening. [PDF]

PLoS ONE, 2012
Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs. Here, we report new human transketolase inhibitors, based on the phenyl urea scaffold,
Cristian Obiol-Pardo, Gema Alcarraz-Vizán, Marta Cascante, Jaime Rubio-Martinez   +3 more
doaj   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Genetic Tools in the Nakaseomyces clade for Evolutionary Comparisons of Signal Transduction Pathways

Yeast, Volume 43, Issue 5, Page 202-213, September 2026.
ABSTRACT The genus Nakaseomyces provides four species that are closely related but have different characteristics. For example, N. glabratus (formerly known as Candida glabrata) is a common human pathogen, whereas N. bracarensis and N. nivariensis have been isolated in clinical settings but are not common human pathogens. N.
Maria Abraham, Christine L. Iosue, Dennis D. Wykoff   +2 more
wiley   +1 more source

Rewiring Carbon Metabolism in Bacillus methanolicus via Heterologous Phosphoketolase Expression Enhances Biomass Yield From Methanol and Reduces CO2 Loss

Microbial Biotechnology, Volume 19, Issue 9, September 2026.
Introducing a phosphoketolase pathway into Bacillus methanolicus enhances methanol‐to‐biomass yields by 18%–24% and reduces CO2 evolution by up to 12%. Coupled with a tunable expression system, this work demonstrates improved carbon conservation and expands metabolic engineering strategies for methylotrophs.
Yael J. Toporek, Jonathan R. Humphreys, Thomas J. Musselwhite, Marcus S. Bray, Katie P. Michel, Kimberly A. Rosenbach, Michael T. Guarnieri   +6 more
wiley   +1 more source

Thiamine Deficiency in Diabetes: Implications for Diabetic Ketoacidosis

Diabetology
Diabetic ketoacidosis (DKA) remains a life-threatening complication of diabetes mellitus with suboptimal outcomes despite standard management. Emerging evidence suggests that thiamine (vitamin B1) deficiency may play an under-recognized role in DKA ...
Mahesh Ramanan, Aashish Kumar
doaj   +1 more source