Results 31 to 40 of about 75,666 (233)
Ensemble switching unveils a kinetic rheostat mechanism of the eukaryotic thiamine pyrophosphate riboswitch. [PDF]
RNA, 2021 Thiamine pyrophosphate (TPP) riboswitches regulate thiamine metabolism by inhibiting the translation of enzymes essential to thiamine synthesis pathways upon binding to thiamine pyrophosphate in cells across all domains of life.
Ma J +6 more
europepmc +2 more sources
Pyruvate content of blood and phosphorylation of thiamine in diabetic coma [PDF]
, 1952 A congestive cardiomyopathy was diagnosed in a girl at the age of 4 weeks. In the weeks following she developed general muscle hypotonia and plasma lactate increased to 8.5 mmol/L.
Florijn, E., Marken Lichtenbelt, H. van
core +16 more sources
Thiamine pyrophosphate improved vascular complications of diabetes in rats with type 2 diabetes by reducing glycation, oxidative stress, and inflammation markers. [PDF]
Med J Islam Repub Iran, 2020 Background: Thiamine deficiency contributes to hyperglycemia and diabetes complications. Thus, in this study, the effect of thiamine pyrophosphate (TPP) on the in vivo and in vitro formation of glycation, oxidative stress, and inflammatory markers (the ...
Mahdavifard S, Nakhjavani M.
europepmc +2 more sources
Molecules, 2021 Phenolic compounds and thiamine may serve as therapies against oxidative stress-related neurodegenerative diseases. However, it is important to note that these components show high instability under changing conditions.
Justyna Piechocka +2 more
doaj +1 more source
Biosynthesis of Thiamin Pyrophosphate [PDF]
EcoSal Plus, 2009 The biosynthesis of thiamin pyrophosphate (TPP) in prokaryotes, as represented by the Escherichia coli and the Bacillus subtilis pathways, is summarized in this review. The thiazole heterocycle is formed by the convergence of three separate pathways.
Christopher T, Jurgenson +2 more
openaire +2 more sources
Organic and biomolecular chemistry, 2023 A common approach to studying thiamine pyrophosphate (TPP)-dependent enzymes is by chemical inhibition with thiamine/TPP analogues which feature a neutral aromatic ring in place of the positive thiazolium ring of TPP.
A. Chan, Terence C. S. Ho, F. Leeper
semanticscholar +1 more source
Advances in Clinical and Experimental Medicine, 2022 BACKGROUND Cyclophosphamide is a drug used in various types of cancer. It can cause oxidative and inflammatory ovarian damage and infertility. Thiamine pyrophosphate (TPP) to be investigated for its effect on cyclophosphamide-induced ovarian damage and ...
M. Ozer +7 more
semanticscholar +1 more source
Pumpkin, Cauliflower and Broccoli as New Carriers of Thiamine Compounds for Food Fortification
Foods, 2021 The aim of the study is to explore the possibility of vegetables being used as carriers of thiamine. The influence of carrier type (thiamine hydrochloride—TCh and thiamine pyrophosphate—TP) for the thiamine stability were investigated.
Krystyna Szymandera-Buszka +4 more
doaj +1 more source
Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter. [PDF]
J Biol Chem, 2017 Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter. Svetlana M. Nabokina, Katsuhisa Inoue, Veedamali S. Subramanian, Judith E. Valle, Hiroaki Yuasa, and Hamid M.
Nabokina SM +5 more
europepmc +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Oxythiamine (OT) and 3-deazathiamine (DAT) are the antimetabolites of thiamine. The aim of study was to compare the effects of OT and DAT pyrophosphates (-PP) on the kinetics of mammalian pyruvate dehydrogenase complex (PDHC) and the in vitro culture of ...
Ewa Grabowska +5 more
doaj +1 more source