Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Oxythiamine (OT) and 3-deazathiamine (DAT) are the antimetabolites of thiamine. The aim of study was to compare the effects of OT and DAT pyrophosphates (-PP) on the kinetics of mammalian pyruvate dehydrogenase complex (PDHC) and the in vitro culture of ...
Ewa Grabowska +5 more
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Redirection of the Reaction Specificity of a Thermophilic Acetolactate Synthase toward Acetaldehyde Formation. [PDF]
PLoS ONE, 2016 Acetolactate synthase and pyruvate decarboxylase are thiamine pyrophosphate-dependent enzymes that convert pyruvate into acetolactate and acetaldehyde, respectively.
Maria Cheng +4 more
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Presence of thiamine pyrophosphate in mammalian peroxisomes [PDF]
BMC Biochemistry, 2007 Abstract Background Thiamine pyrophosphate (TPP) is a cofactor for 2-hydroxyacyl-CoA lyase 1 (HACL1), a peroxisomal enzyme essential for the α-oxidation of phytanic acid and 2-hydroxy straight chain fatty acids. So far, HACL1 is the only known peroxisomal TPP-dependent enzyme in mammals.
Fraccascia, Patrizia +3 more
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High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice. [PDF]
PLoS ONE, 2017 SLC19A3 deficiency, also called thiamine metabolism dysfunction syndrome-2 (THMD2; OMIM 607483), is an autosomal recessive neurodegenerative disorder caused by mutations in SLC19A3, the gene encoding thiamine transporter 2.
Kaoru Suzuki +5 more
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Partial Decay of Thiamine Signal Transduction Pathway Alters Growth Properties of Candida glabrata. [PDF]
PLoS ONE, 2016 The phosphorylated form of thiamine (Vitamin B1), thiamine pyrophosphate (TPP) is essential for the metabolism of amino acids and carbohydrates in all organisms. Plants and microorganisms, such as yeast, synthesize thiamine de novo whereas animals do not.
Christine L Iosue +8 more
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The Involvement of Thiamine Uptake in the Virulence of Edwardsiella piscicida
Pathogens, 2022 Edwardsiella piscicida is a pathogenic bacterium, which can infect a number of fish species and cause a disease termed edwardsiellosis, threatening global fish farming with high prevalence and mortality.
Xin Liu +3 more
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Mechanismus der enzymatischen Freisetzung von Acetaldehyd aus “aktivem Acetaldehyd” (α-hydroxyaethyl-2-thiaminpyrophosphat) [PDF]
, 1961 1. 1.Die Freisetzung von Acetaldehyd aus “Aktivem Acetaldehyd” mit gereinigter Apopyruvatdecarboxylase aus Bierhefe wird durch. Thiaminpyrophosphat gehemmt.
Breslow +13 more
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A Novel Protective Strategy Against Metformin-Induced Renal Injury Involving Adenosine Triphosphate and Thiamine Pyrophosphate [PDF]
Int J Mol SciKocaturk H +9 more
europepmc +3 more sources
Overexpression of Plastid Transketolase in Tobacco Results in a Thiamine Auxotrophic Phenotype [PDF]
, 2015 To investigate the effect of increased plastid transketolase on photosynthetic capacity and growth, tobacco (Nicotiana tabacum) plants with increased levels of transketolase protein were produced.
Fisk, S +7 more
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Can thıamıne pyrophosphate prevent desflurane ınduced hepatotoxıcıty ın rats? [PDF]
Acta Cirúrgica Brasileira, 2016 PURPOSE : To investigate the effects of thiamine pyrophosphate (TPP) against desflurane induced hepatotoxicity. METHODS : Thirty experimental animals were divided into groups as healthy (HG), desflurane control (DCG) , TPP and desflurane group (TDG). 20
Aynur Arslan +8 more
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