Results 31 to 40 of about 6,590 (170)

Pathway of thiamine pyrophosphate synthesis in Micrococcus denitrificans [PDF]

Journal of Bacteriology, 1976
The pathway of thiamine pyrophosphate (TPP) biosynthesis, which is formed either from exogeneously added thiamine or from the pyrimidine and thiazole moieties of thiamine, in Micrococcus denitrificans was investigated. The following indirect evidence shows that thiamine pyrophosphokinase (EC 2.7.6.2) catalyzes the synthesis of TPP from thiamine: (i ...
H, Sanemori, Y, Egi, T, Kawasaki
openaire   +2 more sources

Unveiling the Complete Biosynthetic Pathway of Azacitidine: A Rare 1,3,5‐Triazine Nucleoside Derived From GTP

Angewandte Chemie, EarlyView.
The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang, Qingxu Meng, Lingqi Hua, Mengjun Sun, Qianjin Kang, Min‐Juan Xu, Linquan Bai   +6 more
wiley   +2 more sources

An IscS Persulfide Donates the Sulfur for Ribosomal Protein uL16 Thioamidation

Angewandte Chemie, EarlyView.
YcaO‐catalyzed thioamidation of the ribosomal subunit protein uL16 is widespread in Pseudomonadota bacteria. We identify the iron–sulfur cluster cysteine desulfurase IscS as the sulfur donor via an IscS persulfide and observe direct IscS–uL16 interactions.
Yanqing Xue, Markus W. Voehler, Douglas A. Mitchell   +2 more
wiley   +2 more sources

Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica. [PDF]

PLoS ONE, 2012
Phosphoribosylamine (PRA) is an intermediate in the biosynthetic pathway that is common to thiamine and purines. Glutamine phosphoribosyl pyrophosphate (PRPP) amidotransferase is the product of the purF gene in Salmonella enterica and catalyzes the ...
Mark J Koenigsknecht, Jennifer A Lambrecht, Luke A Fenlon, Diana M Downs   +3 more
doaj   +1 more source

Biosynthetic Pathway of Thiamine Pyrophosphate: a Special Reference to the Thiamine Monophosphate-Requiring Mutant and the Thiamine Pyrophosphate-Requiring Mutant of Escherichia coli [PDF]

Journal of Bacteriology, 1972
Two types of mutants of Escherichia coli were isolated, one of which (mutant 70-23-107) responded to thiamine pyrophosphate, and the other (mutant 70-23-102) to thiamine monophosphate and thiamine pyrophosphate. They were produced by further mutation of a thiamine auxotroph of E.
H, Nakayama, R, Hayashi
openaire   +2 more sources

Pathway Editing Targets for Thiamine Biofortification in Rice Grains

Frontiers in Plant Science, 2018
Thiamine deficiency is common in populations consuming polished rice as a major source of carbohydrates. Thiamine is required to synthesize thiamine pyrophosphate (TPP), an essential cofactor of enzymes of central metabolism. Its biosynthesis pathway has
Anu P. Minhas, Rakesh Tuli, Sanjeev Puri
doaj   +1 more source

Bilateral ovarian ischemia/reperfusion injury and treatment options in rats with an induced model of diabetes [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective(s):This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (I/R) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results.
Omer Erkan Yapca, Mehmet Ibrahim Turan, Bunyamin Borekci, Fatih Akcay, Halis Suleyman   +4 more
doaj  

Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study

Critical Care, 2021
Background Thiamine is a precursor of the essential coenzyme thiamine pyrophosphate required for glucose metabolism; it improves the immune system function and has shown to reduce the risk of several diseases.
Khalid Al Sulaiman, Ohoud Aljuhani, Maram Al Dossari, Asma Alshahrani, Aisha Alharbi, Rahmah Algarni, Majed Al Jeraisy, Shmeylan Al Harbi, Abdulmalik Al Katheri, Fahad Al Eidan, Abdulkareem M. Al Bekairy, Nouf Al Qahtani, Mashael Al Muqrin, Ramesh Vishwakarma, Ghassan Al Ghamdi   +14 more
doaj   +1 more source

Thiamine Is Required for Virulence and Survival of Pseudomonas syringae pv. tomato DC3000 on Tomatoes

Frontiers in Microbiology, 2022
Pseudomonas syringae pv. tomato DC3000 (PstDC3000) is an important plant pathogen that infects tomatoes and Arabidopsis. Thiamine and its derivative thiamine pyrophosphate (TPP) are cofactors that play an important role in the growth and survival of many
Jun Liu, Jun Liu, Jun Liu, Xuejiang Zhang, Xuejiang Zhang, Xuejiang Zhang, Siyi Deng, Siyi Deng, Siyi Deng, Hua Wang, Hua Wang, Hua Wang, Youfu Zhao   +12 more
doaj   +1 more source

Studies on the Nature of the Binding of Thiamine Pyrophosphate to Enzymes

Journal of Biological Chemistry, 1968
Abstract The binding of thiamine pyrophosphate (TPP) to several enzymes has been determined by measuring cofactor-dependent activity after passage of each enzyme through a column of Sephadex G-25 to remove non-protein-bound cofactors. TPP was found to be bound irreversibly to yeast and Zymomonas pyruvate decarboxylases, Aerobacter α-acetolactate ...
A V, Morey, E, Juni
openaire   +2 more sources