Thiamine and Thiamine Pyrophosphate as Non-Competitive Inhibitors of Acetylcholinesterase—Experimental and Theoretical Investigations [PDF]
MoleculesVitamin B1 (thiamine) plays an important role in human metabolism. It is essential for the proper growth and development of the body and has a positive effect on the functioning of the digestive, cardiovascular, and nervous systems.
Łukasz Szeleszczuk, Błaźej Grodner
exaly +7 more sources
Utility of Whole Blood Thiamine Pyrophosphate Evaluation in TPK1-Related Diseases [PDF]
Journal of Clinical Medicine, 2019 TPK1 mutations are a rare, but potentially treatable, cause of thiamine deficiency. Diagnosis is challenging given the phenotypic overlap that exists with other metabolic and neurological disorders.
Enrico Bugiardini +2 more
exaly +6 more sources
The effects of thiamine pyrophosphate on ethanol induced optic nerve damage [PDF]
BMC Pharmacology and Toxicology, 2019 Background We aimed to determine the protective effects of thiamine pyrophosphate on ethanol induced optic neuropathy in an experimental model. Methods The rats were assigned into 4 groups, with 6 rats in each group as follows: healthy controls (HC group)
Turgay Ucak +7 more
doaj +3 more sources
The Protective Effect of Thiamine and Thiamine Pyrophosphate Against Linezolid-Induced Oxidative Liver Damage and Lactic Acidosis in Rats [PDF]
AntioxidantsLinezolid, an antimicrobial agent, has been linked to lactic acidosis, oxidative stress, and liver damage. Oxidative stress is considered to play a key role in this damage.
Bahar Isik +6 more
doaj +3 more sources
Identification and characterisation of thiamine pyrophosphate (TPP) riboswitch in Elaeis guineensis. [PDF]
PLoS ONE, 2020 The oil palm (Elaeis guineensis) is an important crop in Malaysia but its productivity is hampered by various biotic and abiotic stresses. Recent studies suggest the importance of signalling molecules in plants in coping against stresses, which includes ...
Atiqah Subki +4 more
doaj +3 more sources
Direct Observation of Multiple Tautomers of Oxythiamine and their Recognition by the Thiamine Pyrophosphate Riboswitch [PDF]
ACS Chem Biol, 2013 Structural diversification of canonical nucleic acid bases and nucleotide analogues by tautomerism has been proposed to be a powerful on/off switching mechanism allowing regulation of many biological processes mediated by RNA enzymes and aptamers ...
Essigmann, John M. +6 more
core +3 more sources
Mechanism(S) Involved in the Colon-Specific Expression of the Thiamine Pyrophosphate (Tpp) Transporter. [PDF]
PLoS ONE, 2016 Microbiota of the large intestine synthesizes considerable amount of vitamin B1 (thiamine) in the form of thiamine pyrophosphate (TPP). We have recently demonstrated the existence of an efficient and specific carrier-mediated uptake process for TPP in ...
Svetlana M Nabokina +2 more
doaj +3 more sources
Gold(I)-catalysed synthesis of a furan analogue of thiamine pyrophosphate [PDF]
Beilstein Journal of Organic Chemistry, 2014 An analogue of thiamine having a furan ring in place of the thiazolium ring has been synthesised by a short and efficient route, involving gold(I)-catalysed cyclisation of an alkynyl alcohol to form the furan ring.
Amjid Iqbal +2 more
doaj +3 more sources
The Testicular Protection Effect of Thiamine Pyrophosphate Against Cisplatin-treated Male Rats
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Infertility is a worldwide problem affecting both genders, it can be defined as the inability of the adult males to make a fertile woman pregnant after one year of regular intercourse. Cisplatin considers one of the most potent antineoplastic drugs that
Maitham Abd Ali Mnati +2 more
doaj +2 more sources
Functional analysis of thiamine pyrophosphate-responsive riboswitches in human bacterial pathogens of the ESKAPE group using a dual-luciferase reporter gene assay [PDF]
Journal of BacteriologyThiamine pyrophosphate (TPP)-responsive riboswitches are genetic elements in bacteria that regulate the expression of genes coding for proteins involved in the biosynthesis and transport of thiamine (vitamin B1). Following uptake, cytoplasmic thiamine is
Anna Hübenthal +3 more
doaj +2 more sources