Presence of thiamine pyrophosphate in mammalian peroxisomes [PDF]
BMC Biochemistry, 2007 Abstract Background Thiamine pyrophosphate (TPP) is a cofactor for 2-hydroxyacyl-CoA lyase 1 (HACL1), a peroxisomal enzyme essential for the α-oxidation of phytanic acid and 2-hydroxy straight chain fatty acids. So far, HACL1 is the only known peroxisomal TPP-dependent enzyme in mammals.
Fraccascia, Patrizia +3 more
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Triazole-Based Thiamine Analogues as Inhibitors of Thiamine Pyrophosphate-Dependent Enzymes: 1,3-Dicarboxylate for Metal Binding [PDF]
ACS OmegaTerence C. S. Ho +2 more
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Thermodynamic examination of the pyrophosphate sensor helix in the thiamine pyrophosphate riboswitch [PDF]
RNA, 2011 Riboswitches are functional mRNA that control gene expression. Thiamine pyrophosphate (TPP) binds tothi-box riboswitch RNA and allosterically inhibits genes that code for proteins involved in the biosynthesis and transport of thiamine. Thiamine binding to the pyrimidine sensor helix and pyrophosphate binding to the pyrophosphate sensor helix cause ...
Stephanie, Furniss, Neena, Grover
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High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice. [PDF]
PLoS ONE, 2017 SLC19A3 deficiency, also called thiamine metabolism dysfunction syndrome-2 (THMD2; OMIM 607483), is an autosomal recessive neurodegenerative disorder caused by mutations in SLC19A3, the gene encoding thiamine transporter 2.
Kaoru Suzuki +5 more
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Partial Decay of Thiamine Signal Transduction Pathway Alters Growth Properties of Candida glabrata. [PDF]
PLoS ONE, 2016 The phosphorylated form of thiamine (Vitamin B1), thiamine pyrophosphate (TPP) is essential for the metabolism of amino acids and carbohydrates in all organisms. Plants and microorganisms, such as yeast, synthesize thiamine de novo whereas animals do not.
Christine L Iosue +8 more
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The Involvement of Thiamine Uptake in the Virulence of Edwardsiella piscicida
Pathogens, 2022 Edwardsiella piscicida is a pathogenic bacterium, which can infect a number of fish species and cause a disease termed edwardsiellosis, threatening global fish farming with high prevalence and mortality.
Xin Liu +3 more
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Can thıamıne pyrophosphate prevent desflurane ınduced hepatotoxıcıty ın rats? [PDF]
Acta Cirúrgica Brasileira, 2016 PURPOSE : To investigate the effects of thiamine pyrophosphate (TPP) against desflurane induced hepatotoxicity. METHODS : Thirty experimental animals were divided into groups as healthy (HG), desflurane control (DCG) , TPP and desflurane group (TDG). 20
Aynur Arslan +8 more
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The Effect of Thiamine Concentration on the Antioxidative Activity Indices in Tea Extracts
Antioxidants, 2019 The aim of the study was to determine correlations between the concentration of thiamine in systems and indicators of the antioxidative activity of ethanol tea extracts in the presence of soybean oil.
Justyna Piechocka +4 more
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Biomolecules, 2022 Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon (Salmo salar) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat (Sprattus sprattus) and herring ...
Marja Keinänen +7 more
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Biosynthesis of Thiamine Pyrophosphate in Escherichia coli [PDF]
Journal of Bacteriology, 1972 In Escherichia coli , thiamine pyrophosphate is synthesized from thiamine monophosphate. Free thiamine is not involved as an intermediate in de novo synthesis of thiamine pyrophosphate.
H, Nakayama, R, Hayashi
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