Results 21 to 30 of about 75,666 (233)

Novel TPP-riboswitch activators bypass metabolic enzyme dependency [PDF]

Frontiers in Chemistry, 2014
Riboswitches are conserved regions within mRNA molecules that bind specific metabolites and regulate gene expression. TPP-riboswitches, which respond to thiamine pyrophosphate (TPP), are involved in the regulation of thiamine metabolism in numerous ...
Günter eMayer, Christina eLünse, Colin eSuckling, Fraser eScott   +3 more
doaj   +3 more sources

The Role of Thiamine Pyrophosphate in Prevention of Cisplatin Ototoxicity in an Animal Model [PDF]

The Scientific World Journal, 2013
Objective. The aim of this study was to evaluate the effectiveness of thiamine pyrophosphate against cisplatin-induced ototoxicity in guinea pigs. Materials and Methods. Healthy guinea pigs (n=18) were randomly divided into three groups.
Ozan Kuduban, Cuneyt Kucur, Ebru Sener, Halis Suleyman, Fatih Akcay   +4 more
doaj   +2 more sources

Optimizing thiamine pyrophosphate metabolism enhances crop yield and quality [PDF]

Nature Communications
Global food security requires sustainable strategies to improve crop yield and nutrition. Although thiamine pyrophosphate (TPP), the active form of vitamin B1, plays a central role in energy metabolism, redox homeostasis, and carbon assimilation, its ...
Yun Luo, Yu Liu, Jie Liu, Xiaojing Liu, Huinan Li, Yu Wu, Junli Zhao, Yuebin Wang, Wenjie Fang, Liumei Jian, Lin Zhuo, Wenqiang Li, Junpeng Zhan, Alisdair R. Fernie, Jianbing Yan   +14 more
doaj   +2 more sources

Comparative Study on the Protective Effect of Thiamine and Thiamine Pyrophosphate Against Hydroxychloroquine-Induced Cardiomyopathy in Rats [PDF]

Life
Background: Hydroxychloroquine (HCQ), widely used in autoimmune and inflammatory diseases, has been associated with cardiotoxicity driven by oxidative, mitochondrial, and metabolic disturbances.
Izzet Emir, Bulent Yavuzer, Bahadir Suleyman, Cengiz Sarigul, Ali Sefa Mendil, Esra Tuba Sezgin, Durdu Altuner, Cebrail Gursul, Halis Suleyman   +8 more
doaj   +2 more sources

Analysis of the Use of Carrots, Cauliflower and Broccoli Waste Materials as a Matrix for Thiamine [PDF]

Foods
The investigation aimed to use selected waste plant materials as thiamine matrices for fortification purposes. Thiamine hydrochloride (TCh) and thiamine pyrophosphate (TP) constituted the sources of thiamine.
Krystyna Eleonora Szymandera-Buszka, Agata Jankowska, Paweł Juszczak   +2 more
doaj   +2 more sources

Thiamine Pyrophosphate Effects on Newborn Piglets as a Measure of Vitality and Survival Indicators [PDF]

Animals
The objective of this study was to evaluate the prophylactic effect of thiamine pyrophosphate (TPP) on the vitality scores of piglets based on their behavior and survival. A total of 149 piglets born from 15 multiparous sows were evaluated. The sows were
Paloma Islas-Fabila, Herlinda Bonilla-Jaime, Patricia Roldán-Santiago, Luis Alberto de la Cruz-Cruz, Ofelia Limón-Morales, Carlos Antonio Jiménez-Collado, Héctor Orozco-Gregorio   +6 more
doaj   +2 more sources

Examination of the Effects of Thiamine and Thiamine Pyrophosphate on Doxorubicin-Induced Experimental Cardiotoxicity

Journal of Cardiovascular Pharmacology and Therapeutics, 2014
Background and Purpose: To investigate the effect of thiamine and thiamine pyrophosphate on doxorubicin-induced cardiotoxicity biochemically and histopathologically and to examine whether doxorubicin cardiotoxicity is related to the conversion of thiamine into thiamine pyrophosphate and inhibition of thiamine ...
Suleyman, Halis, Akcay, Fatih, Sener, Ebru, POLAT, Beyzagül   +3 more
openaire   +4 more sources

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease [PDF]

Advanced Science
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a common chronic liver disease. This study investigates the anti‐MASLD effects of dietary prebiotic stachyose (STA) on disease progression identifying Butyricimonas virosa as a key ...
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
doaj   +2 more sources

Mitochondrial transport and metabolism of the vitamin B-derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NAD⁺ , and related diseases: A review. [PDF]

IUBMB Life, 2022
Multiple mitochondrial matrix enzymes playing key roles in metabolism require cofactors for their action. Due to the high impermeability of the mitochondrial inner membrane, these cofactors need to be synthesized within the mitochondria or be imported ...
Palmieri F, Monné M, Fiermonte G, Palmieri L.   +3 more
europepmc   +2 more sources

Crystal structure of Escherichia coli thiamine pyrophosphate-sensing riboswitch in the apo state. [PDF]

Structure, 2023
SUMMARY The thiamine pyrophosphate (TPP)-sensing riboswitch is one of the earliest discovered and most widespread riboswitches. Numerous structural studies have been reported for this riboswitch bound with various ligands.
Lee HK, Lee YT, Fan L, Wilt HM, Conrad CE, Yu P, Zhang J, Shi G, Ji X, Wang YX, Stagno JR.   +10 more
europepmc   +2 more sources