An atlas of plant selenium metabolism
New Phytologist, EarlyView.Summary Selenium (Se) is not only a rare and toxic element but also an essential micronutrient for humans and animals that is often in short supply. Terrestrial plants do not require Se, but it can have growth‐promoting or negative effects, depending on the exposure level.
Jeroen van der Woude +3 more
wiley +1 more source
Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells
Scientific Reports, 2017 Accumulating evidences suggest that p53 is a key coordinator of cellular events triggered by oxidative stress often associated with the impairment in thiamine metabolism and its functions.
Sergiy Chornyy +2 more
doaj +1 more source
THIAMINE SUPPLEMENT THERAPY IMPROVES EJECTION FRACTION VALUE IN STAGE II HEART FAILURE PATIENTS
Folia Medica Indonesiana, 2017 Thiamine, also called vitamin B1, is a water soluble vitamin that is involved in the formation of ATP in cells. The active metabolite of thiamine is a co-enzyme thiamine pyrophosphate (TPP) that plays an active role in carbohydrate metabolism and the ...
Rafi Jikrona +2 more
doaj +1 more source
Evolutionary analysis of the TPP-dependent enzyme family [PDF]
, 2008 The evolutionary relationships of the thiamine pyrophosphate (TPP)-dependent family of enzymes was investigated by generation of a neighbor joining phylogenetic tree using sequences from the conserved pyrophosphate (PP) and pyrimidine (Pyr) binding ...
Costelloe, S.J., Dalby, P.A., Ward, J.M.
core
Inhibition of Fructose-1,6-bisphosphatase by Aminoimidazole Carboxamide Ribotide Prevents Growth of Salmonella enterica purH Mutants on Glycerol [PDF]
, 2006 The enzyme fructose-1,6-bisphosphatase (FBP) is key regulatory point in gluconeogenesis. Mutants of Salmonella enterica lacking purH accumulate 5-amino-4-imidazole carboxamide ribotide (AICAR) and are unable to utilize glycerol as sole carbon and energy ...
Boyd, Jeffrey M. +2 more
core +1 more source
Biosynthetic Pathway of Thiamine Pyrophosphate: a Special Reference to the Thiamine Monophosphate-Requiring Mutant and the Thiamine Pyrophosphate-Requiring Mutant of Escherichia coli [PDF]
Journal of Bacteriology, 1972 Two types of mutants of Escherichia coli were isolated, one of which (mutant 70-23-107) responded to thiamine pyrophosphate, and the other (mutant 70-23-102) to thiamine monophosphate and thiamine pyrophosphate. They were produced by further mutation of a thiamine auxotroph of E.
H, Nakayama, R, Hayashi
openaire +2 more sources
Plant Biotechnology Journal, EarlyView.ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li +7 more
wiley +1 more source
Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes [PDF]
, 2012 Increased renal clearance of thiamine (vitamin B1) occurs in experimental and clinical diabetes producing thiamine insufficiency mediated by impaired tubular re-uptake and linked to the development of diabetic nephropathy.
A Adaikalakoteswari +42 more
core +7 more sources
Riboswitches as Drug Targets for Antibiotics
Antibiotics, 2021 Riboswitches reside in the untranslated region of RNA and regulate genes involved in the biosynthesis of essential metabolites through binding of small molecules.
Vipul Panchal, Ruth Brenk
doaj +1 more source
High-resolution structures of Lactobacillus salivarius transketolase in the presence and absence of thiamine pyrophosphate. [PDF]
Acta Crystallogr F Struct Biol Commun, 2015 Lukacik P +6 more
europepmc +3 more sources