Results 91 to 100 of about 13,523 (239)

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain [PDF]

, 2010
Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Noeske, Jonas, Schwalbe, Harald (Prof. Dr.), Wöhnert, Jens   +2 more
core  

A structural phylogeny for understanding 2-oxoacid oxidoreductase function [PDF]

, 2018
2-Oxoacid:ferredoxin oxidoreductases (OFORs) are essential enzymes in microbial one-carbon metabolism. They use thiamine pyrophosphate to reversibly cleave carbon-carbon bonds, generating low potential (~-500 mV) electrons. Crystallographic analysis of a
Chen, Yang-Ting, Drennan, Catherine L., Gibson, Marcus Ian   +2 more
core   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Effect of thiamine pyrophosphate on cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats [PDF]

, 2022
Mehmet Özer, Sefa İnce, Betül Gündoğdu, Mehmet Aktaş, Kemine Uzel, Cebrail Gürsul, Halis Süleyman, Zeynep Süleyman   +7 more
openalex   +1 more source

Mild symptomatic Wernicke’s Encephalopathy: a case report

Journal of Health Sciences, 2018
Wernicke’s encephalopathy (WE) is an acute, neuropsychiatric syndrome which results from a deficiency in vitamin B1 (thiamine), which in its biologically active form, thiamine pyrophosphate, is an essential coenzyme in several biochemical pathways in the
Maria Sofia Cotelli, Patrizia Civelli, Marinella Turla   +2 more
doaj   +1 more source

Biowaste Composting as a Sustainable Platform for Bacterial CO Production: Evidence From cooS Gene Expression and Microbial Community Profiling

GCB Bioenergy, Volume 18, Issue 5, May 2026.
This study demonstrates, for the first time, the expression of the cooS gene during composting, confirming microbial CO production under mesophilic conditions. The results highlight composting as a novel waste‐to‐biochemicals process, offering a sustainable, low‐carbon pathway for generating carbon monoxide via bacterial CO dehydrogenase activity ...
Karolina Sobieraj, Aneta Urbanek, Zofia Steczkiewicz   +2 more
wiley   +1 more source

A common structural motif in thiamin pyrophosphate‐binding enzymes

FEBS Letters, 1989
The amino acid sequences of a wide range of enzymes that utilize thiamin pyrophosphate (TPP) as cofactor have been compared. A common sequence motif approximately 30 residues in length was detected, beginning with the highly conserved sequence ‐GDG‐ and concluding with the highly conserved sequence ‐NN‐. Secondary structure predictions suggest that the
Hawkins, Christopher F., Borges, Adolfo, Perham, Richard N.   +2 more
openaire   +2 more sources

Thiamine Deficiency in Diabetes: Implications for Diabetic Ketoacidosis

Diabetology
Diabetic ketoacidosis (DKA) remains a life-threatening complication of diabetes mellitus with suboptimal outcomes despite standard management. Emerging evidence suggests that thiamine (vitamin B1) deficiency may play an under-recognized role in DKA ...
Mahesh Ramanan, Aashish Kumar
doaj   +1 more source

Engineering of 2‐ketoacid Decarboxylases for Production of Isobutanol and Other Fusel Alcohols in Saccharomyces cerevisiae

Biotechnology and Bioengineering, Volume 123, Issue 4, Page 1036-1049, April 2026.
ABSTRACT Isobutanol is a fusel alcohol that can be produced microbially for use as a biofuel or upgraded into sustainable aviation fuel (SAF). A key enzyme in the isobutanol biosynthetic pathway is 2‐ketoacid decarboxylase (KDC), which irreversibly decarboxylates 2‐ketoisovalerate (KIV) to yield isobutyraldehyde.
Joshua J. Dietrich, Maelia Dziedzic, Jia Sun, Sri Harsha Adusumilli, Carla Gonçalves, Chris Todd Hittinger, Brian F. Pfleger   +6 more
wiley   +1 more source

Small Molecule‐Based Conditional Gene Regulation: Advances and Applications

Chemistry–Methods, Volume 6, Issue 4, April 2026.
The precise, temporal, and reversible control of gene expression using small molecule ligands is crucial for understanding complex cellular functions and is rapidly advancing the field of synthetic biology. Small molecule‐mediated conditional gene regulation has widespread applications, including bio‐manufacturing, cellular reprogramming, gene therapy,
Mohd Afaque Ansari, Riddhima Sharma, Priyanka Swami, Ambadas B. Rode   +3 more
wiley   +1 more source