Results 111 to 120 of about 13,523 (239)

Nanomedicine Targeting Macrophage Immunometabolism in Atherosclerosis: Mechanisms and Therapeutic Prospects

open access: yesOrgan Medicine, Volume 3, Issue 1, Page 27-53, March 2026.
ABSTRACT Atherosclerosis, a chronic inflammatory–metabolic disorder, remains a leading cause of cardiovascular morbidity worldwide. This review explores the emerging paradigm of nanomedicine‐based targeting of macrophage immunometabolic reprogramming as a potentially transformative strategy for atherosclerosis treatment.
Zhenyu Liu, Wenfan Yang, Na Wang, Ya Wu
wiley   +1 more source

The wide phenotypic spectrum of thiamine metabolism dysfunction syndrome 5 and its treatment

open access: yesOrphanet Journal of Rare Diseases
Thiamine metabolism dysfunction syndrome 5 (TMDS5) is a rare inborn error of metabolism caused by variants in TPK1, leading to reduced TPK levels. This enzyme is crucial for the production of thiamine pyrophosphate, the active form of thiamine, a vital ...
Alice Dallan   +8 more
doaj   +1 more source

Thiamine deficiency in the western diet and dementia risk [PDF]

open access: yes, 2016
This article has been accepted for publication in British Journal of Nutrition. The version of record, Richard Hoffman, ‘Thiamine deficiency in the Western diet and dementia risk’, British Journal of Nutrition, Vol 116(1): 188-189, first published online
Richard Hoffman, Velísek
core   +1 more source

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

open access: yesCell Proliferation, Volume 59, Issue 3, March 2026.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie   +8 more
wiley   +1 more source

An Unexpected Route to an Essential Cofactor: Escherichia coli Relies on Threonine for Thiamine Biosynthesis

open access: yesmBio, 2016
Metabolism consists of biochemical reactions that are combined to generate a robust metabolic network that can respond to perturbations and also adapt to changing environmental conditions.
Jannell V. Bazurto   +2 more
doaj   +1 more source

Fragment screening against the thiamine pyrophosphate riboswitchthiM

open access: yesChem. Sci., 2011
Riboswitches are regions of mRNA that bind selectively certain metabolites, thereby regulating gene expression. We have developed a method, which uses a combination of biophysical techniques (equilibrium dialysis, waterLOGSY and T2 relaxation-edited NMR spectroscopy and isothermal titration calorimetry) that allows screening and identification of novel
Elena Cressina   +4 more
openaire   +1 more source

The roles of B vitamins in phytoplankton nutrition: new perspectives and prospects [PDF]

open access: yes, 2017
B vitamins play essential roles in central metabolism. These organic water-soluble molecules act as, or as part of, coenzymes within the cell. Unlike land plants, many eukaryotic algae are auxotrophic for certain B vitamins.
Allen   +47 more
core   +1 more source

Chromatography of beer [PDF]

open access: yes, 2013
The objectives of the review are the collection, concise description and evaluation of the various chromatographic techniques used for the separation and quantitative determination of macro- and microcomponents present in ...
Cserháti, Tibor, Szőgyi, Mária
core  

Studies on the metabolism of beta-hydroxy- aspartic acid [PDF]

open access: yes, 1975
The content of beta-hydroxyaspartic acid was measured in the urine of man and several species of animals. The configuration of urinary beta-hydroxyaspartic acid was deduced to be L-erythro in form by chromatographic comparisons with authentic samples. An
Ikegami, Takuma
core   +1 more source

Oxidative decarboxylation of retinoic acid in microsomes of rat liver and kidney

open access: yesJournal of Lipid Research, 1968
Liver and kidney microsomes have been found to catalyze a rapid decarboxylation of retinoic acid in vitro. The reaction requires NADPH and Fe2+, and is further stimulated by the presence of pyrophosphate.
Anita B. Roberts, Hector F. DeLuca
doaj   +1 more source

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