Results 111 to 120 of about 75,666 (233)

Inhibition of Fructose-1,6-bisphosphatase by Aminoimidazole Carboxamide Ribotide Prevents Growth of Salmonella enterica purH Mutants on Glycerol [PDF]

, 2006
The enzyme fructose-1,6-bisphosphatase (FBP) is key regulatory point in gluconeogenesis. Mutants of Salmonella enterica lacking purH accumulate 5-amino-4-imidazole carboxamide ribotide (AICAR) and are unable to utilize glycerol as sole carbon and energy ...
Boyd, Jeffrey M., Dougherty, Michael J., Downs, Diana M.   +2 more
core   +1 more source

A common structural motif in thiamin pyrophosphate‐binding enzymes

FEBS Letters, 1989
The amino acid sequences of a wide range of enzymes that utilize thiamin pyrophosphate (TPP) as cofactor have been compared. A common sequence motif approximately 30 residues in length was detected, beginning with the highly conserved sequence ‐GDG‐ and concluding with the highly conserved sequence ‐NN‐. Secondary structure predictions suggest that the
Hawkins, Christopher F., Borges, Adolfo, Perham, Richard N.   +2 more
openaire   +2 more sources

The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3708-3722, June 2026.
ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li, Zhiteng Luo, Zhaoyin He, Jie Tang, Wuke Wei, Ruoting Zhan, Huihao Zhou, Dongming Ma   +7 more
wiley   +1 more source

Effect of Thiamine Pyrophosphate (Bicarbossilasi®) Administration on the Exercising Horse Metabolism [PDF]

, 2017
Thiamine pyrophosphate (TPP) is the phosphorylated and active form of thiamine (Vitamin B1). We hypothesized that the administration of thiamine in its immediately available active form could provide the metabolic pathways for a supplement able to ...
Faillace, Vanessa, Laus, Fulvio, Marini, Carlotta, Marvasi, L, Paggi, Emanuele, Serri, Evelina, Spaterna, Andrea, Tesei, Beniamino, Vullo, Cecilia   +8 more
core  

A structural phylogeny for understanding 2-oxoacid oxidoreductase function [PDF]

, 2018
2-Oxoacid:ferredoxin oxidoreductases (OFORs) are essential enzymes in microbial one-carbon metabolism. They use thiamine pyrophosphate to reversibly cleave carbon-carbon bonds, generating low potential (~-500 mV) electrons. Crystallographic analysis of a
Chen, Yang-Ting, Drennan, Catherine L., Gibson, Marcus Ian   +2 more
core   +1 more source

Biowaste Composting as a Sustainable Platform for Bacterial CO Production: Evidence From cooS Gene Expression and Microbial Community Profiling

GCB Bioenergy, Volume 18, Issue 5, May 2026.
This study demonstrates, for the first time, the expression of the cooS gene during composting, confirming microbial CO production under mesophilic conditions. The results highlight composting as a novel waste‐to‐biochemicals process, offering a sustainable, low‐carbon pathway for generating carbon monoxide via bacterial CO dehydrogenase activity ...
Karolina Sobieraj, Aneta Urbanek, Zofia Steczkiewicz   +2 more
wiley   +1 more source

Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica

Microbial Cell, 2017
In Salmonella enterica, aminoimidazole carboxamide ribotide (AICAR) is a purine biosynthetic intermediate and a substrate of the AICAR transformylase/IMP cyclohydrolase (PurH) enzyme.
Jannell V. Bazurto, Stephen P. Dearth, Eric D. Tague, Shawn R. Campagna, Diana M. Downs   +4 more
doaj   +1 more source

Studies on the metabolism of beta-hydroxy- aspartic acid [PDF]

, 1975
The content of beta-hydroxyaspartic acid was measured in the urine of man and several species of animals. The configuration of urinary beta-hydroxyaspartic acid was deduced to be L-erythro in form by chromatographic comparisons with authentic samples. An
Ikegami, Takuma
core   +1 more source

An atlas of plant selenium metabolism

New Phytologist, Volume 250, Issue 4, Page 2041-2060, May 2026.
Summary Selenium (Se) is not only a rare and toxic element but also an essential micronutrient for humans and animals that is often in short supply. Terrestrial plants do not require Se, but it can have growth‐promoting or negative effects, depending on the exposure level.
Jeroen van der Woude, Mark G. M. Aarts, Michela Schiavon, Antony van der Ent   +3 more
wiley   +1 more source

Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis

Advanced Science, Volume 13, Issue 23, 23 April 2026.
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan   +6 more
wiley   +1 more source