Results 121 to 130 of about 75,666 (233)

Engineering of 2‐ketoacid Decarboxylases for Production of Isobutanol and Other Fusel Alcohols in Saccharomyces cerevisiae

open access: yesBiotechnology and Bioengineering, Volume 123, Issue 4, Page 1036-1049, April 2026.
ABSTRACT Isobutanol is a fusel alcohol that can be produced microbially for use as a biofuel or upgraded into sustainable aviation fuel (SAF). A key enzyme in the isobutanol biosynthetic pathway is 2‐ketoacid decarboxylase (KDC), which irreversibly decarboxylates 2‐ketoisovalerate (KIV) to yield isobutyraldehyde.
Joshua J. Dietrich   +6 more
wiley   +1 more source

Biocatalytic Indigo Synthesis From L‐Tryptophan Using a Three‐Step Cascade Without Cofactor Regeneration

open access: yesChemBioChem, Volume 27, Issue 8, April 2026.
A self‐sufficient, NAD(P)H‐independent enzyme cascade for the synthesis of indigo from L‐tryptophan. The minimal cascade uses pyruvate, a byproduct of tryptophan cleavage, to generate hydrogen peroxide, which fuels the key hydroxylation of indole to indoxyl by an engineered tyrosine hydroxylase.
Vivian P. Willers   +2 more
wiley   +1 more source

Role of tautomerism in RNA biochemistry [PDF]

open access: yes, 2015
Heterocyclic nucleic acid bases and their analogs can adopt multiple tautomeric forms due to the presence of multiple solvent-exchangeable protons.
Essigmann, John M.   +2 more
core   +1 more source

Small Molecule‐Based Conditional Gene Regulation: Advances and Applications

open access: yesChemistry–Methods, Volume 6, Issue 4, April 2026.
The precise, temporal, and reversible control of gene expression using small molecule ligands is crucial for understanding complex cellular functions and is rapidly advancing the field of synthetic biology. Small molecule‐mediated conditional gene regulation has widespread applications, including bio‐manufacturing, cellular reprogramming, gene therapy,
Mohd Afaque Ansari   +3 more
wiley   +1 more source

The wide phenotypic spectrum of thiamine metabolism dysfunction syndrome 5 and its treatment

open access: yesOrphanet Journal of Rare Diseases
Thiamine metabolism dysfunction syndrome 5 (TMDS5) is a rare inborn error of metabolism caused by variants in TPK1, leading to reduced TPK levels. This enzyme is crucial for the production of thiamine pyrophosphate, the active form of thiamine, a vital ...
Alice Dallan   +8 more
doaj   +1 more source

Nutritional deficiencies in homeless persons with problematic drinking:A systematic review [PDF]

open access: yes, 2017
BACKGROUND: A significant proportion of homeless people drink alcohol excessively and this can lead to malnutrition and consequent medical problems.
Bonner, Adrian   +7 more
core   +3 more sources

An Unexpected Route to an Essential Cofactor: Escherichia coli Relies on Threonine for Thiamine Biosynthesis

open access: yesmBio, 2016
Metabolism consists of biochemical reactions that are combined to generate a robust metabolic network that can respond to perturbations and also adapt to changing environmental conditions.
Jannell V. Bazurto   +2 more
doaj   +1 more source

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]

open access: yes, 2014
While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P.   +11 more
core   +1 more source

Chromatography of beer [PDF]

open access: yes, 2013
The objectives of the review are the collection, concise description and evaluation of the various chromatographic techniques used for the separation and quantitative determination of macro- and microcomponents present in ...
Cserháti, Tibor, Szőgyi, Mária
core  

Thiamine deficiency in the western diet and dementia risk [PDF]

open access: yes, 2016
This article has been accepted for publication in British Journal of Nutrition. The version of record, Richard Hoffman, ‘Thiamine deficiency in the Western diet and dementia risk’, British Journal of Nutrition, Vol 116(1): 188-189, first published online
Richard Hoffman, Velísek
core   +1 more source

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