Results 51 to 60 of about 8,762 (179)

TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimens

Diagnostic Pathology, 2008
In several tumors the transketolase activity, controlled inter alia by enzymes of the pentose phosphate pathway which is an alternative, energy generating reaction-cascade to glycolysis, has been correlated with proliferation.
Zabel Peter, Vollmer Ekkehard, Branscheid Detlev, Kähler Daniel, Schultz Holger, Goldmann Torsten   +5 more
doaj   +1 more source

Co‐Production of Mycoprotein, Carotenoids, and B Vitamins From Cheese Whey by Neurospora intermedia

Journal of Food Science, Volume 91, Issue 7, July 2026.
ABSTRACT Cheese whey, a nutrient‐rich dairy byproduct that requires management due to its high organic load, was valorized using an integrated biorefinery platform with the edible fungus Neurospora intermedia to simultaneously produce mycoprotein, carotenoids, and B vitamins (B1, B2, B3, B6).
Farzaneh Dianatdar, Zahra Etemadifar, Mohammad J. Taherzadeh   +2 more
wiley   +1 more source

Multi‐Omics Landscape of Paraspinal Muscles in Spinal Muscular Atrophy With Scoliosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Most spinal muscular atrophy (SMA) patients develop severe scoliosis by late adolescence. Given that the paraspinal muscles—particularly the multifidus—are indispensable for maintaining spinal stability, their site‐specific multi‐omics characteristics in SMA remain insufficiently defined. Herein, integrated multi‐omics sequencing was performed
Zhen Wang, Junduo Zhao, Xu'an Huang, Weiyun Chen, Jianxiong Shen   +4 more
wiley   +1 more source

From the Proteome to Therapeutics: A Multi‐Database Approach to Drug Discovery in Periodontitis—An Exploratory Pilot Study

Journal of Clinical Periodontology, Volume 53, Issue 7, Page 990-1004, July 2026.
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo, Annette Murr, Birte Holtfreter, Sebastian‐Edgar Baumeister, Peter Meisel, Uwe Völker, Werner Weitschies, Henry Völzke, Philipp Kanzow, Elke Hammer, Manuela Gesell Salazar, Thomas Kocher   +11 more
wiley   +1 more source

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, Volume 49, Issue 7, Page 3543-3559, July 2026.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source

Severe thiamine deficiency in eastern Baltic cod (Gadus morhua).

PLoS ONE, 2020
The eastern Baltic cod (Gadus morhua) population has been decreasing in the Baltic Sea for at least 30 years. Condition indices of the Baltic cod have decreased, and previous studies have suggested that this might be due to overfishing, predation, lower ...
Josefin Engelhardt, Oscar Frisell, Hanna Gustavsson, Tomas Hansson, Rajlie Sjöberg, Tracy K Collier, Lennart Balk   +6 more
doaj   +1 more source

Biophysical characterization of the inactivation of E. coli transketolase by aqueous co-solvents

Scientific Reports, 2021
Transketolase (TK) has been previously engineered, using semi-rational directed evolution and substrate walking, to accept increasingly aliphatic, cyclic, and then aromatic substrates.
Phattaraporn Morris, Ribia García-Arrazola, Leonardo Rios-Solis, Paul A. Dalby   +3 more
doaj   +1 more source

Genetic Factors Associated with Toe Walking in Children

Вопросы современной педиатрии, 2020
The article describes genetic factors associated with toe walking in children. Association of gait abnormality with variants in genes listed below is shown: PMP22 (peripheral myelin protein 22), EGR2 (early growth response protein 2), AIFM1 (apoptosis ...
David Pomarino, Anneke Thren, Stefaine Morigeau, Johanna R. Thren, Anna A. Emelina   +4 more
doaj   +1 more source

Biomanufacturing and Scale‐Up: Pathways to Biochemicals, Biofuels, and Biomaterials

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Carolina A. Barcelos, Pavel Dvořák, Charles J. Foster, Juan Nogales, Juan L. Ramos, Shamlan M. S. Reshamwala, Davinia Salvachúa   +6 more
wiley   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source