Results 71 to 80 of about 8,654 (179)

Mechanism-Based Studies of the Active Site-Directed Inhibition and Activation of Enzyme Transketolase [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1988
Derivatives of phenyl-keto butenoic acids have been reported to be inhibitors of pyruvate decarboxylase, (PDC). The inhibition of transketolase, a thiamine requiring enzyme such as PDF, by meta nitrophenyl derivative of 2-oxo-3-butenoic acid (MNPB) is ...
Bijan Farzami
doaj  

Biosynthesis of the benzylpyrrolidine precursor in anisomycin by a unique ThDP-dependent enzyme

Synthetic and Systems Biotechnology
Anisomycin (compound 1), a multifunctional pyrrolidine antibiotic, primarily inhibits protein biosynthesis by binding to the ribosome. Upon binding to the ribosome, the para-phenol moiety of anisomycin inserts completely into the hydrophobic crevice of ...
Yongjian Qiao, Junbo Wang, Dashan Zhang, Xiaoqing Zheng, Baixin Lin, Yongkang Huang, Yulin Liao, Zixin Deng, Lingxin Kong, Delin You   +9 more
doaj   +1 more source

THE CALCIUM BINDING SITES OF THE BAKERS' YEAST TRANSKETOLASE [PDF]

Journal of Sciences, Islamic Republic of Iran, 1992
The calcium binding sites of Bakers' Yeast Transketolase (TK) was elucidated by estimating the pKa values of the functional groups that bind to calcium.
doaj  

Transketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation

Cell Reports
Summary: Glioblastoma (GBM) is a highly lethal malignant brain tumor with poor survival rates, and chemoresistance poses a significant challenge to the treatment of patients with GBM.
Minjie Fu, Mengli Zhang, Licheng Zhang, Yuan Feng, Chao Gao, Hao Xu, Jinsen Zhang, Huaichao Zhang, Tianping Peng, Youjun Chu, Yonghe Wu, Pu Wang, Dan Ye, Ying Mao, Wei Hua   +14 more
doaj   +1 more source

The transketolase exchange reaction in vitro [PDF]

Biochemical Journal, 1971
M G, Clark, J F, Williams, P F, Blackmore   +2 more
openaire   +2 more sources

Biophysical and structural studies on transketolases

Understanding the mechanism and structure of transketolase is valuable across a range of disciplines, including enzymology, synthetic biology, drug development, and biocatalysis. Beyond offering insights into enzyme catalysis and thiamin-dependent chemistry, this knowledge enables the rational design of transketolase variants with altered substrate ...
von Pappenheim, F., Tittmann, K.
openaire   +4 more sources

Thiamine Allocation and Deficiency Status Throughout the Life Cycle of Cod. [PDF]

Ecol Evol
Hauber MM, Todisco V, Nordahl O, Tibblin P, Fridolfsson E, Kärvegård E, Hylander S.   +6 more
europepmc   +1 more source

Thiamine status of whitefish (Coregonus maraena) in the Baltic Sea. [PDF]

PLoS One
Hauber MM, Nordahl O, Todisco V, Fridolfsson E, Tibblin P, Hylander S.   +5 more
europepmc   +1 more source

Reassessing Transketolase Assays: Methodological Considerations for Detecting Functional Thiamine Deficiency. [PDF]

Ann N Y Acad Sci
Edwards KA.
europepmc   +1 more source

Alpha-Lipoic Acid and Benfotiamine in Diabetic Peripheral Neuropathy: A Critical Review of Mechanistic Rationale and Clinical Evidence Within a Nutritional Therapeutic Framework. [PDF]

Nutrients
Ciubotaru A, Grosu C, Alexa D, Cucu LE, Schreiner TG, Bistriceanu CE, Maştaleru A, Azoicāi D, Vamanu A, Patrascu A, Cuciureanu DI, Ignat EB.   +11 more
europepmc   +1 more source