Results 81 to 90 of about 10,904 (208)

From the Proteome to Therapeutics: A Multi‐Database Approach to Drug Discovery in Periodontitis—An Exploratory Pilot Study

Journal of Clinical Periodontology, Volume 53, Issue 7, Page 990-1004, July 2026.
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo, Annette Murr, Birte Holtfreter, Sebastian‐Edgar Baumeister, Peter Meisel, Uwe Völker, Werner Weitschies, Henry Völzke, Philipp Kanzow, Elke Hammer, Manuela Gesell Salazar, Thomas Kocher   +11 more
wiley   +1 more source

New Role of Water in Transketolase Catalysis

, 2023
Transketolase catalyzes the interconversion of keto and aldo sugars. Its coenzyme is thiamine diphosphate. The binding of keto sugar with thiamine diphosphate is possible only after C2 deprotonation of its thiazole ring. It is believed that deprotonation
Olga N. Solovjeva, Solovjeva, Olga N.
core   +1 more source

PREPARATION AND PROPERTIES OF TRANSKETOLASE FROM PORK LIVER

, 1960
Transketolase of pork liver has been purified 90-fold and separated from ribulose 5-phosphate 3-epimerase. The transketolase is most stable between pH 7.5 and 8.5 and below 40 °C. The pH range for optimum activity is between 7.6 and 8.1.
F. J. Simpson
core   +1 more source

Progress on the role of transketolase in occurrence and treatment of diabetes and its complications [PDF]

Jichu yixue yu linchuang
Transketolase (TKT) is an important enzyme that catalyzes the non-oxidative phase group transfer reaction of pentose phosphate pathway (PPP), and is involved in the metabolism of various energy substances in the body, such as glucose, ribose, nucleotides
WANG Zeying, LIU Zhi, TAI Yu, YANG Zhongbin, SU Yan
doaj   +1 more source

A NADH-dependent transketolase assay in erythrocyte hemolysates

, 1971
simple and specific method for the assay of transketolase activity in erythrocyte hemolysates based on the measurement of NADH consumption is described. The test conditions are discussed and the results are compared with a colorimetric method.
Smeets, E.H.J., Muller, H., H. Muller, J. De Wael, E.H.J. Smeets   +4 more
core   +1 more source

Extraordinary therapeutic effect of PSMA radioligand therapy in treatment-refractory progressive metastatic prostate cancer with the transketolase inhibitor benfo-oxythiamine as a radiosensitizer—A case report

Frontiers in Medicine
Herein we report, for the first time, the therapeutic response of a prostate cancer patient with the thiamine antagonist benfo-oxythiamine (B-OT) added to prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (PRLT).
Carsten S. Kramer, Jingjing Zhang, Richard P. Baum   +2 more
doaj   +1 more source

Comparative Genomics of Mycoplasma bovis Strains Reveals That Decreased Virulence with Increasing Passages Might Correlate with Potential Virulence-Related Factors

Frontiers in Cellular and Infection Microbiology, 2017
Mycoplasma bovis is an important cause of bovine respiratory disease worldwide. To understand its virulence mechanisms, we sequenced three attenuated M.
Muhammad A. Rasheed, Muhammad A. Rasheed, Muhammad A. Rasheed, Jingjing Qi, Jingjing Qi, Xifang Zhu, Xifang Zhu, He Chenfei, He Chenfei, Harish Menghwar, Harish Menghwar, Farhan A. Khan, Farhan A. Khan, Gang Zhao, Gang Zhao, Muhammad Zubair, Muhammad Zubair, Changmin Hu, Yingyu Chen, Huanchun Chen, Huanchun Chen, Huanchun Chen, Huanchun Chen, Aizhen Guo, Aizhen Guo, Aizhen Guo, Aizhen Guo   +26 more
doaj   +1 more source

Hydrogen bond networks facilitate the conversion of aliphatic aldehydes in the charged active site of S. cerevisiae transketolase [PDF]

, 2017
Naturally, transketolase (TK, E.C. 2.2.1.1) catalyzes asymmetric C-C bond formation in glycolysis derived metabolites to afford carbohydrates for nucleotide synthesis and the production of essential aromatic amino acids.[1] While results obtained earlier
Hanefeld, Ulf, Eustace, Stephen J., Robert Marsden, Stefan, Gjonaj, Lorina   +3 more
core   +1 more source

Biomanufacturing and Scale‐Up: Pathways to Biochemicals, Biofuels, and Biomaterials

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Carolina A. Barcelos, Pavel Dvořák, Charles J. Foster, Juan Nogales, Juan L. Ramos, Shamlan M. S. Reshamwala, Davinia Salvachúa   +6 more
wiley   +1 more source

Isolation of transketolase gene, subcellular localization, and transketolase protein structure studies of sugarcane (Saccharum officinarum. L) [PDF]

, 2013
This study focused on isolation, identification, subcellular localisation, protein structure prediction of transketolase enzyme from sugarcane, Saccharum officinarum.
Kalhori, Nahid
core   +1 more source