Results 81 to 90 of about 10,076 (212)

Extraordinary therapeutic effect of PSMA radioligand therapy in treatment-refractory progressive metastatic prostate cancer with the transketolase inhibitor benfo-oxythiamine as a radiosensitizer—A case report

Frontiers in Medicine
Herein we report, for the first time, the therapeutic response of a prostate cancer patient with the thiamine antagonist benfo-oxythiamine (B-OT) added to prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (PRLT).
Carsten S. Kramer, Jingjing Zhang, Richard P. Baum   +2 more
doaj   +1 more source

Comparative Genomics of Mycoplasma bovis Strains Reveals That Decreased Virulence with Increasing Passages Might Correlate with Potential Virulence-Related Factors

Frontiers in Cellular and Infection Microbiology, 2017
Mycoplasma bovis is an important cause of bovine respiratory disease worldwide. To understand its virulence mechanisms, we sequenced three attenuated M.
Muhammad A. Rasheed, Muhammad A. Rasheed, Muhammad A. Rasheed, Jingjing Qi, Jingjing Qi, Xifang Zhu, Xifang Zhu, He Chenfei, He Chenfei, Harish Menghwar, Harish Menghwar, Farhan A. Khan, Farhan A. Khan, Gang Zhao, Gang Zhao, Muhammad Zubair, Muhammad Zubair, Changmin Hu, Yingyu Chen, Huanchun Chen, Huanchun Chen, Huanchun Chen, Huanchun Chen, Aizhen Guo, Aizhen Guo, Aizhen Guo, Aizhen Guo   +26 more
doaj   +1 more source

A NADH-dependent transketolase assay in erythrocyte hemolysates

, 1971
simple and specific method for the assay of transketolase activity in erythrocyte hemolysates based on the measurement of NADH consumption is described. The test conditions are discussed and the results are compared with a colorimetric method.
Smeets, E.H.J., Muller, H.
core   +1 more source

Mechanistic Studies of Escherichia Coli Transketolase

, 2013
The enzyme transketolase is found in nature as part of the Pentose Phosphate Pathway to rearrange large sugar phosphates. It also is an important enzyme for carboncarbon bond formation for industrial biocatalysis.
Martin, Mathew Paul
core  

In situ localization of transketolase activity in epithelial cells of different rat tissues and subcellularly in liver parenchymal cells

, 2006
Metabolic mapping of enzyme activities (enzyme histochemistry) is an important tool to understand (patho)physiological functions of enzymes. A new enzyme histochemical method has been developed to detect transketolase activity in situ in various rat ...
Jonker, Ard, Boren, Joan, Centelles, Josep J., Frederiks, Wilma M., Ramos-Montoya, Antonio, Bosch, Klazien S., Cascante, Marta, Vreeling, Heleen   +7 more
core   +2 more sources

Synthesis of specially designed probes to broaden transketolase scope

, 2013
International audienceEfficient, biocompatible, stereospecific strategies were developed to prepare eight probes to assay transketolase (TK) variants with new substrate specificities.
Guérard-Hélaine, Christine, C. Guérard‐Hélaine, T. Eljezi, Hecquet, Laurence, Lemaire, Marielle, Legeret, Bertrand, G. Simon, Bouzon, M., Simon, Grégory, Castillo, José A., Hélaine, Virgil, V. Hélaine, M. Bouzon, J. A. Castillo, Eljezi, T., Marlière, Philippe, B. Legeret, F. Charmantray, M. Lemaire, Charmantray, Franck, L. Hecquet, P. Marlière   +21 more
core   +2 more sources

Heterologous expression of human transketolase

, 2020
Transketolase belongs to the family of thiamin diphosphate dependent enzymes. The aim of this study was to establish a bacterial expression system for human transketolase in order to investigate the functional characteristics of mammalian transketolases.
Gerhard Schenk, Ronald G Duggleby, Peter F Nixon   +2 more
core  

Association of transketolase polymorphisms with measures of polyneuropathy in patients with recently diagnosed diabetes.

, 2017
BACKGROUND: Shunting of glycolytic intermediates into the pentose phosphate pathway (PPP) has been suggested to protect from hyperglycaemia-induced microvascular damage.
Müssig, K., Schleicher, E., Ziegler, D., Knebel, B., Häring, H.-U., Fleming, T., Papanas, N., Szendrödi, J., Al-Hasani, H., Roden, M., Strom, A., Nawroth, P.P.   +11 more
core   +1 more source

Dietary reference values for thiamin

EFSA Journal, 2016
Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived dietary reference values (DRVs) for thiamin (vitamin B1).
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), Dominique Turck, Jean‐Louis Bresson, Barbara Burlingame, Tara Dean, Susan Fairweather‐Tait, Marina Heinonen, Karen Ildico Hirsch‐Ernst, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Grażyna Nowicka, Kristina Pentieva, Yolanda Sanz, Alfonso Siani, Anders Sjödin, Martin Stern, Daniel Tomé, Henk Van Loveren, Marco Vinceti, Peter Willatts, Christel Lamberg‐Allardt, Hildegard Przyrembel, Inge Tetens, Jelena Gudelj Rakic, Sofia Ioannidou, Agnès deSesmaisons‐Lecarré, Annette Cecilia Forss, Monika Neuhäuser‐Berthold   +28 more
doaj   +1 more source

Amino acid precursors for the detection of transketolase activity in Escherichia coli auxotrophs

, 2009
International audienceProbes were developed for the in vivo detection of transketolase activity by the use of a complementation assay in Escherichia coli auxotrophs They combine the d-threo ketose moiety recognised by transketolase and the side chain of ...
Simon, Grégory, Hélaine, Virgil, Marlière, P., Hecquet, Laurence, Marlière, Philippe, Bouzon, Madeleine, Charmantray, Franck, Legeret, Bertrand, Bouzon, M.   +8 more
core   +1 more source