Results 101 to 110 of about 10,076 (212)

Cooperativity and flexibility of active sites in homodimeric transketolase

, 1998
Here we summarize evidence for non-equivalence of two structurally similar active sites in transketolase and other thiamine-dependent enzymes. This non-equivalence takes place when the enzymes interact with various ligands (inhibitors, cations, coenzyme ...
Kochetov, German A, Marina V Kovina, Kovina, Marina V, German A Kochetov   +3 more
core   +1 more source

The Two-Species Model of transketolase explains donor substrate-binding, inhibition and heat-activation [PDF]

, 2020
We recently characterised a low-activity form of E. coli transketolase, TKlow, which also binds the cofactor thiamine pyrophosphate (TPP) with an affinity up to two-orders of magnitude lower than the previously known high TPP-affinity and high-activity ...
Dalby, PA, Wilkinson, HC
core  

THE CALCIUM BINDING SITES OF THE BAKERS' YEAST TRANSKETOLASE [PDF]

Journal of Sciences, Islamic Republic of Iran, 1992
The calcium binding sites of Bakers' Yeast Transketolase (TK) was elucidated by estimating the pKa values of the functional groups that bind to calcium.
doaj  

Transketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation

Cell Reports
Summary: Glioblastoma (GBM) is a highly lethal malignant brain tumor with poor survival rates, and chemoresistance poses a significant challenge to the treatment of patients with GBM.
Minjie Fu, Mengli Zhang, Licheng Zhang, Yuan Feng, Chao Gao, Hao Xu, Jinsen Zhang, Huaichao Zhang, Tianping Peng, Youjun Chu, Yonghe Wu, Pu Wang, Dan Ye, Ying Mao, Wei Hua   +14 more
doaj   +1 more source

Effects of furazolidone, PCB77, PCB126, Aroclor 1248, paraquat and p,p'-DDE on transketolase activity in embryonal chicken brain

, 2002
The effect of in ovo exposure to PCBs, DDE and paraquat on transketolase activity was measured in 19-day-old chicken embryos. Furazolidone was used as a positive control for decreased activity of the enzyme.
Roode, D.F., de, Bosveld, A.T.C., de Roode, D.F., Vuorinen, P.J.   +3 more
core   +1 more source

Biophysical and structural studies on transketolases

Understanding the mechanism and structure of transketolase is valuable across a range of disciplines, including enzymology, synthetic biology, drug development, and biocatalysis. Beyond offering insights into enzyme catalysis and thiamin-dependent chemistry, this knowledge enables the rational design of transketolase variants with altered substrate ...
von Pappenheim, F., Tittmann, K.
openaire   +4 more sources

Gene cloning, protein characterization and structural prediction of Amaranthus tricolor transketolase [PDF]

, 2013
This study focused on gene cloning, protein characterization and structural prediction of Transketolase enzyme from Amaranthus tricolor. Oxidative Pentose Phosphate Pathway (OPPP) oxidative pentose phosphate pathway (OPPP) fulfills an essential role in
Rajeendran, Allgendran
core  

The transketolase exchange reaction in vitro [PDF]

Biochemical Journal, 1971
M G, Clark, J F, Williams, P F, Blackmore   +2 more
openaire   +2 more sources

Thiamine Allocation and Deficiency Status Throughout the Life Cycle of Cod. [PDF]

Ecol Evol
Hauber MM, Todisco V, Nordahl O, Tibblin P, Fridolfsson E, Kärvegård E, Hylander S.   +6 more
europepmc   +1 more source

Thiamine status of whitefish (Coregonus maraena) in the Baltic Sea. [PDF]

PLoS One
Hauber MM, Nordahl O, Todisco V, Fridolfsson E, Tibblin P, Hylander S.   +5 more
europepmc   +1 more source