Results 101 to 110 of about 10,904 (208)

Biosynthesis of the benzylpyrrolidine precursor in anisomycin by a unique ThDP-dependent enzyme

Synthetic and Systems Biotechnology
Anisomycin (compound 1), a multifunctional pyrrolidine antibiotic, primarily inhibits protein biosynthesis by binding to the ribosome. Upon binding to the ribosome, the para-phenol moiety of anisomycin inserts completely into the hydrophobic crevice of ...
Yongjian Qiao, Junbo Wang, Dashan Zhang, Xiaoqing Zheng, Baixin Lin, Yongkang Huang, Yulin Liao, Zixin Deng, Lingxin Kong, Delin You   +9 more
doaj   +1 more source

Comparison of transketolase model with crystal structure.

, 2012
A) Superimposition of the homology model of human transketolase (in pink) with the recently released crystal structure (in white). B) Close view of the residues used for pharmacophore definition, in the homology model (in pink and thin residues) and in ...
Cristian Obiol-Pardo (179509), Jaime Rubio-Martinez (179518), Gema Alcarraz-Vizán (179513), Marta Cascante (67954)   +3 more
core   +1 more source

Interactions with hemoglobin: A source of error in measurements of transketolase activity in hemolysates

, 1989
Measurements of the activity of transketolase in human erythrocyte lysates by an assay coupled to NADH oxidation indicate that interactions of assay substrates with hemoglobin can give rise to overestimations of transketolase activity.
Nixon P.F., Waltham M., Ioannoni B., Price J., Grudzinski A.   +4 more
core   +1 more source

THE CALCIUM BINDING SITES OF THE BAKERS' YEAST TRANSKETOLASE [PDF]

Journal of Sciences, Islamic Republic of Iran, 1992
The calcium binding sites of Bakers' Yeast Transketolase (TK) was elucidated by estimating the pKa values of the functional groups that bind to calcium.
doaj  

Transketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation

Cell Reports
Summary: Glioblastoma (GBM) is a highly lethal malignant brain tumor with poor survival rates, and chemoresistance poses a significant challenge to the treatment of patients with GBM.
Minjie Fu, Mengli Zhang, Licheng Zhang, Yuan Feng, Chao Gao, Hao Xu, Jinsen Zhang, Huaichao Zhang, Tianping Peng, Youjun Chu, Yonghe Wu, Pu Wang, Dan Ye, Ying Mao, Wei Hua   +14 more
doaj   +1 more source

Rational substrate and enzyme engineering of transketolase for aromatics [PDF]

, 2012
The uses of 3-formylbenzoic acid and 4-formylbenzoic acid as molecular probes along with previous and new transketolase mutants revealed the factors governing the rate of reaction between transketolase and aromatic aldehydes.
Dalby, PA, Payongsri, P, MacMurray, A, Steadman, D, Strafford, J, Hailes, HC   +5 more
core  

Amino acid precursors for the detection of transketolase activity in Escherichia coli auxotrophs

, 2009
International audienceProbes were developed for the in vivo detection of transketolase activity by the use of a complementation assay in Escherichia coli auxotrophs They combine the d-threo ketose moiety recognised by transketolase and the side chain of ...
Simon, Grégory, Hélaine, Virgil, Marlière, P., Hecquet, Laurence, Marlière, Philippe, Bouzon, Madeleine, Charmantray, Franck, Legeret, Bertrand, Bouzon, M., Grégory Simon, Madeleine Bouzon, Laurence Hecquet, Virgil Hélaine, Franck Charmantray, Philippe Marlière, Bertrand Légeret   +15 more
core   +1 more source

Biophysical and structural studies on transketolases

Understanding the mechanism and structure of transketolase is valuable across a range of disciplines, including enzymology, synthetic biology, drug development, and biocatalysis. Beyond offering insights into enzyme catalysis and thiamin-dependent chemistry, this knowledge enables the rational design of transketolase variants with altered substrate ...
Tittmann, Kai, Pappenheim, Fabian Rabe von   +1 more
openaire   +4 more sources

Functional thiamine deficiency in patients with chronic kidney disease in Northeast Thailand. [PDF]

Future Sci OA
Nahok K, Chalermwat C, Cha'on U, Jusakul A, Boonsiri P, Chamdam A, Kraiklang R, Tippayawat P, Anutrakulchai S, Lert-Itthiporn W.   +9 more
europepmc   +1 more source

Synthesis, characterization, X-ray diffraction, <i>in silico</i> studies and <i>in vitro</i> biological evaluation of acylthiourea-derived thiazole-2-imines. [PDF]

RSC Adv
Kangara EF, Singh T, Khoza P, Naidu D, Mkwananzi NP, Senzani S, Oyeneyin OE, Fernandes MA, Van Zyl W, Tukulula M.   +9 more
europepmc   +1 more source