Results 61 to 70 of about 8,654 (179)

Chaetocin, a Natural Inhibitor of Transketolase, Suppresses the Non-Oxidative Pentose Phosphate Pathway and Inhibits the Growth of Drug-Resistant Non-Small Cell Lung Cancer

Antioxidants
Worldwide, lung cancer is the most common cause of cancer-related death, which is made worse by the development of drug resistance during treatment. It is urgent to develop new therapeutic methods and small molecule drugs for tumor resistance. Chaetocin,
Song Li, Zhanying Lu, Wenli Jiang, Yao Xu, Ran Chen, Jie Wang, Binghua Jiao, Xiaoling Lu   +7 more
doaj   +1 more source

Development of a Novel Assay for Synthesis and Hydrolysis of Sedoheptulose 1,7-bisphosphate (SBP) in vitro by Combinations of Purified Fructose 1,6-bisphosphate aldolases (FBA) Proteins and Fructose 1,6-bisphosphatases (FBPase) Proteins from Bacillus methanolicus MGA3

Bio-Protocol, 2014
Bacillus methanolicus (B. methanolicus) is a Gram-positive, thermotolerant, and facultative methylotrophic bacterium that can use the one-carbon (C1) compound methanol as a source of carbon and energy (Schendel et al., 1990; Arfman et al., 1997; Arfman ...
Jessica Stolzenberger, Steffen Lindner, Marcus Persicke, Trygve Brautaset, Volker Wendisch   +4 more
doaj   +1 more source

When Viruses Talk through Extracellular Vesicles: a New Perspective on Sars‐Cov‐2‐Induced Neurodegeneration

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT SARS‐CoV‐2 infection is linked to persistent neurological symptoms Post‐Acute Sequelae SARS‐CoV‐2 (neuro‐PASC) and elevated risk of neurodegenerative disease, but molecular events connecting acute viral injury to long‐term CNS dysfunction remain unclear.
Gunjan Bawne, Loet Coenen, Erik Nutma, Jinte Middeldorp, Magdalena J. Lorenowicz   +4 more
wiley   +1 more source

Progress on the role of transketolase in occurrence and treatment of diabetes and its complications [PDF]

Jichu yixue yu linchuang
Transketolase (TKT) is an important enzyme that catalyzes the non-oxidative phase group transfer reaction of pentose phosphate pathway (PPP), and is involved in the metabolism of various energy substances in the body, such as glucose, ribose, nucleotides
WANG Zeying, LIU Zhi, TAI Yu, YANG Zhongbin, SU Yan
doaj   +1 more source

Extraordinary therapeutic effect of PSMA radioligand therapy in treatment-refractory progressive metastatic prostate cancer with the transketolase inhibitor benfo-oxythiamine as a radiosensitizer—A case report

Frontiers in Medicine
Herein we report, for the first time, the therapeutic response of a prostate cancer patient with the thiamine antagonist benfo-oxythiamine (B-OT) added to prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (PRLT).
Carsten S. Kramer, Jingjing Zhang, Richard P. Baum   +2 more
doaj   +1 more source

Comparative Genomics of Mycoplasma bovis Strains Reveals That Decreased Virulence with Increasing Passages Might Correlate with Potential Virulence-Related Factors

Frontiers in Cellular and Infection Microbiology, 2017
Mycoplasma bovis is an important cause of bovine respiratory disease worldwide. To understand its virulence mechanisms, we sequenced three attenuated M.
Muhammad A. Rasheed, Muhammad A. Rasheed, Muhammad A. Rasheed, Jingjing Qi, Jingjing Qi, Xifang Zhu, Xifang Zhu, He Chenfei, He Chenfei, Harish Menghwar, Harish Menghwar, Farhan A. Khan, Farhan A. Khan, Gang Zhao, Gang Zhao, Muhammad Zubair, Muhammad Zubair, Changmin Hu, Yingyu Chen, Huanchun Chen, Huanchun Chen, Huanchun Chen, Huanchun Chen, Aizhen Guo, Aizhen Guo, Aizhen Guo, Aizhen Guo   +26 more
doaj   +1 more source

Inhibition of transketolase by p‐hydroxyphenylpyruvate

FEBS Letters, 1999
The effect of p‐hydroxyphenylpyruvate, a natural analogue of transketolase substrate, on the catalytic activity of the enzyme was investigated. p‐Hydroxyphenylpyruvate proved to be a reversible and competitive inhibitor of transketolase with respect to substrate; it was also able to displace thiamine diphosphate from holotransketolase. The data suggest
Solovjeva, Olga N, Kochetov, German A
openaire   +2 more sources

Dietary reference values for thiamin

EFSA Journal, 2016
Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived dietary reference values (DRVs) for thiamin (vitamin B1).
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), Dominique Turck, Jean‐Louis Bresson, Barbara Burlingame, Tara Dean, Susan Fairweather‐Tait, Marina Heinonen, Karen Ildico Hirsch‐Ernst, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Grażyna Nowicka, Kristina Pentieva, Yolanda Sanz, Alfonso Siani, Anders Sjödin, Martin Stern, Daniel Tomé, Henk Van Loveren, Marco Vinceti, Peter Willatts, Christel Lamberg‐Allardt, Hildegard Przyrembel, Inge Tetens, Jelena Gudelj Rakic, Sofia Ioannidou, Agnès deSesmaisons‐Lecarré, Annette Cecilia Forss, Monika Neuhäuser‐Berthold   +28 more
doaj   +1 more source

Transketolase and vitamin B1 influence on ROS-dependent neutrophil extracellular traps (NETs) formation.

PLoS ONE, 2019
Neutrophil extracellular traps (NETs) are a recently identified, web-like, extracellular structure composed of decondensed nuclear DNA and associated antimicrobial granules.
Donporn Riyapa, Darawan Rinchai, Veerachat Muangsombut, Chayanin Wuttinontananchai, Mohammed Toufiq, Damien Chaussabel, Manabu Ato, Jenefer M Blackwell, Sunee Korbsrisate   +8 more
doaj   +1 more source

Kinetics of reconstruction of holo‐transketolase [PDF]

FEBS Letters, 1975
Kochetov, G.A., Philippov, P.P., Razjivin, A.P., Tikhomirova, N.K.   +3 more
openaire   +2 more sources