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A New Convergent Synthesis of Thiamine Hydrochloride
Helvetica Chimica Acta, 1990AbstractThiamine hydrochloride (1a; 3‐[(4‐amino‐2‐methylpyrimidin‐5‐yl)methyl]‐5‐(2‐hydroxyethyl)‐4‐methylthia‐zolium chloride hydrochloride; vitamin B1) has been synthesized in excellent yield by condensation of 3‐mercapto‐4‐oxopentyl acetate (5a) with 3, 4‐dihydro‐7‐methylpyrimido[4, 5‐d]pyrimidine (4) in formic acid.
Pierre Contant +3 more
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Polymorphic Changes of Thiamine Hydrochloride During Granulation and Tableting
Drug Development and Industrial Pharmacy, 2001Thiamine hydrochloride was granulated using an instrumented fluidized bed granulator (Hüttlin HKC 05-TJ). Granules consisting of pure thiamine hydrochloride were produced using an aqueous solution of thiamine hydrochloride as the granulating liquid. The effects of process variables such as inlet air temperature, spray rate, and amount of granulating ...
K, Wöstheinrich, P C, Schmidt
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Preparation and Evaluation of Thiamine N-Cyclohexylsulfamate Hydrochloride
Journal of Pharmaceutical Sciences, 1962The presently available salts of thiamine are known to have a characteristic bitter taste. The N-cyclohexylsulfamic acid salt of thiamine hydrochloride was prepared and was found to have a taste which was greatly improved over that of the presently available salts of thiamine.
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Journal of Veterinary Pharmacology and Therapeutics, 1986
Thomas, K.W. Oral treatment of polioencephalomalacia and subclinical thiamine deficiency with thiamine propyl disulphide and thiamine hydrochloride. J. vet. Pharmacol. Therap. 9, 402–411.Thiaminase type 1 production by Bacillus thiaminolyticus and activity in vitro were repressed by the primary substate thiamine and by thiamine monophosphate and ...
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Thomas, K.W. Oral treatment of polioencephalomalacia and subclinical thiamine deficiency with thiamine propyl disulphide and thiamine hydrochloride. J. vet. Pharmacol. Therap. 9, 402–411.Thiaminase type 1 production by Bacillus thiaminolyticus and activity in vitro were repressed by the primary substate thiamine and by thiamine monophosphate and ...
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Interaction between thiamine hydrochloride and lipoic acid.
Die Pharmazie, 1977An interaction between thiamine hydrochloride and DL-alpha-lipoic acid in aqueous solution was depicted. Evidence is presented through spectrophotometric as well as vapour pressure measurements to show that thiamine hydrochloride and DL-alpha-lipoic acid form a single 1:1 complex.
H O, Ammar, H A, Salama
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A Toxicity Study of Thiamine Hydrochloride
Science, 1946T J, Haley, A M, Flesher
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