Results 51 to 60 of about 1,925 (186)

Synthesis and antimicrobial activity of some new 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties [PDF]

, 2010
Some new sulfur-nitrogen heterocyclic systems such as 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties were synthesized via heterocyclization of the key intermediate 4 ...
Ali, Tarik El-Sayed, El-Kazak, Azza Mohammed, Azza Mohammed El-Kazak, Tarik El-Sayed Ali   +3 more
core   +1 more source

Diastereoselective Synthesis of Polysubstituted 2‐Amidino Thiolanes via Cycloaddition of N‐Thioacyl Amidines With Donor–Acceptor Cyclopropanes

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A MgBr2‐catalyzed (3+2) cycloaddition between N‐thioacyl amidines and donor–acceptor cyclopropanes provides rapid access to 2‐amidino‐thiolanes in good yields and with high diastereoselectivities. The method displays broad substrate scope and offers an efficient route to sulfur‐containing amidine scaffolds of potential biological relevance.
Laurine Tual, Thomas Cherioux, Romain Pertschi, Gaëlle Blond, Mihaela Gulea   +4 more
wiley   +1 more source

Sultams as Dual Inhibitors of Human Carbonic Anhydrase and Thioredoxin Reductase

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
A series of sultam‐based N‐acyl derivatives with potential applications as dual TrxR1 and CA inhibitors were synthesized and evaluated. TrxR1 screening identified several active compounds, with inhibitory potency influenced by the type and orientation of substituents.
Aleksandrs Pustenko, Raitis Bobrovs, Venkatesan Saravanan, Kathir Avan, Simone Carradori, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +8 more
wiley   +1 more source

A New Synthesis of 4H-1,4-Thiazines and Benzothiazines

, 1978
Benzothiazines I [R1 = H, R2 = Me, Ph; R1 = Me, R2 = Ph; R1R2 = (CH2)4] and thiazines II [R1 = H, R2 = Me; R1R2 = (CH2)4] were prepd. in 23-59% yield by treatment of III or IV with p-MeC6H4SO3H in MePh at reflux for 30 min. III were prepd.
E. Novellino, F. Chioccara, G. Prota, OLIVA, Leone   +3 more
core   +1 more source

Studies of heterocyclic chemistry. Part 25. Intramolecular cyclisations of N-acylarylethanethioamides leading to thiazoles, 4H-1,3-thiazines, 4H-pyrido[3,2-e]-1,3-thiazines, and 4H-1,3-benzothiazines

, 1982
Thiazoles, 4H-1,3-thiazines, 4H-pyrido[3,2-e]-1,3-thiazines, and 4H-1,3-benzothiazines have been synthesized from N-acyl-(1,3-dithiol-2-ylidene)arylethanethioamides derived from the reactions of 4-aryl-3-halogenoacylthio-4-aryl-3-(2 ...
Nishiwaki, Tarozaemon, 阿部, 憲孝, Nakamura, Reiko, Sasaoka, Yoshiro, Kochi, Hirafumi, Kawamura, Etsuko, Soneda, Kazumi   +6 more
core  

Facile Odourless Quantitative Synthesis of 3-Hydroxy-3,4-Dihydro-2H-1,4-Thiazines

, 2016
A novel sulpha-Michael addition/formal [3+3] annulation cascade reaction of 1,4-dithiane-2,5-diol and 1,2-diaza-1,3-dienes by a one-pot base-catalyzed strategy has been developed.
MARI, GIACOMO, Lucia De Crescentini, Fabio Mantellini, SANTEUSANIO, STEFANIA, Orazio A. Attanasi, FAVI, GIANFRANCO, Giacomo Mari, Stefania Santeusanio, DE CRESCENTINI, LUCIA, MANTELLINI, FABIO, Gianfranco Favi, ATTANASI, ORAZIO ANTONIO   +11 more
core   +1 more source

2-Isothiocyanatobenzylpyridinium bromide - An intermediate for the synthesis of 2-arylamino-4H-benzo[d][1,3]thiazines

, 1986
2-Bromomethylphenyl isothiocyanate reacts with pyridine to yield 2-isothiocyanatobenzylpyridinium bromide, which afforded N-aryl-N'-(2-benzylpyridinium)thiourea bromides. Deprotonization of the latter with aqueous NaOH gave N-aryl-N'-(2-benzylpyridinium)
Pavol Kristian, Jozef Gonda
core   +1 more source

Synthesis of Schiff's Bases from 2-Amino-4H-1, 3-Oxazine / Thiazine and Substituted Aldehydes and their Transition Metal Complexes

, 2021
: Objective: Many methods can be found in literature for the synthesis a Oxazines and Thiazines. Few are reported for one-pot multi component cyclo-condensation of an alkayane urea / Thiourea and Aldehyde to 2- amino-4H-1, 3-Oxazines or Thiazines ...
Dr. M. B. Swami, D.T. Biradar, null null
core   +1 more source

Preparation of 1,3-thiazines: Sulphur analogues of nucleic acid pyrimidine bases

, 1970
Sulphur analogues of uracil and thymine have been prepased, in which the N1 atom of the pyrimidine base has been replaced by a sulphur atom. A number of general synthetic methods are described for the synthesis of these 1,3-thiazines.
EN Cain, RN Warrener
core   +1 more source

Synthesis of heterocyclic compounds via enamines. Part 8. Acid-catalysed transformations in 4,4,6-trimethyl-1,4-dihydropyrimidine-2(3H)-thione derivatives and related compounds

, 1980
1-Substituted 4,4,6-trimethyl-1,4-dihydropyrimidine-2(3H)-thiones (2) on heating in 11M-HCl at 100-110° are converted into the corresponding 2-substituted-amino-4,6,6-trimethyl-6H-1,3-thiazines (4) and/or thioureas.
Singh, Paramjit, Harjit Singh
core   +1 more source