Results 131 to 140 of about 12,572 (245)

2-substituted 5-acetyl-4-thiazolyl triflates as useful building blocks for the preparation of functionalized thiazoles

, 1999
The readily available 2-substituted 5-acetyl-4-thiazolyl triflates 2 are useful building blocks for the preparation of functionalised thiazoles by means of palladium-catalysed cross-coupling reactions with organometallic reagents and alkoxycarbonylation ...
O. Attanasi, E. Rossi, A. Arcadi, B. Guidi, S. Santeusanio   +4 more
core   +1 more source

Anticancer 1,3-thiazole Derivatives: In Vitro Evaluation and in Silico Tubulin/Lipoxygenase Inhibition [PDF]

Pharmaceutical and Biomedical Research
Background: Addressing cancer treatment and drug resistance is critical because cancer remains a leading cause of death worldwide. Targeting key enzymes, such as tubulin and lipoxygenase, may yield new strategies to impede tumor growth and enhance ...
Yasin SarveAhrabi, Saina Aqa Abedi, Mastaneh Ahmadirad, Nakisa Zarrabi Ahrabi   +3 more
doaj  

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, Volume 32, Issue 36, 24 September 2026.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Diarylethene‐Containing Photoswitchable Analogues of Tubulysins—Design, Synthesis, Biological, and Structural Evaluation

European Journal of Organic Chemistry, Volume 29, Issue 35, 19 September 2026.
Diarylethene‐containing cyclic tubulysin analogues were designed, synthesized, and evaluated as light‐responsive cytotoxic agents. One analogue showed reversible photoswitching, photoregulated tubulin polymerization inhibition, and photoform‐dependent cytotoxicity.
Anna Iampolska, Sergii Afonin, Oleg Babii, Mahri Park, Juan Estévez‐Gallego, Michel O. Steinmetz, Andrea E. Prota, Anne S. Ulrich, David R. Spring, Igor V. Komarov   +9 more
wiley   +1 more source

Recent Applications of Propylene Carbonate as a Solvent in Sustainable Organic Synthesis

ChemSusChem, Volume 19, Issue 17, 14 September 2026.
This review evaluates propylene carbonate (PC) as a non‐toxic green solvent in organic synthesis, highlighting its performance in key reactions including cross‐couplings, asymmetric hydrogenations, peptide synthesis and biocatalysis. Across these processes, PC delivers yields comparable to conventional and alternative green solvents.
Laura G. Aguilar‐Sanchez, Christopher R. Jones   +1 more
wiley   +1 more source

2-Substituted-5-acetyl-2-aryl-4-thiazolyltriflates as useful building blocks for the preparation of functionalized thiazoles

, 1999
The readily available 2-substituted 5-acetyl-4-thiazolyl triflates 2 are useful building blocks for the preparation of functionalised thiazoles by means of palladium-catalysed cross-coupling reactions with organometallic reagents and alkoxycarbonylation ...
ARCADI A, O. Attanasi, SANTEUSANIO, STEFANIA, E. Rossi, GUIDI B, A. Arcadi, B. Guidi, S. Santeusanio, ATTANASI, ORAZIO ANTONIO, ROSSI E.   +9 more
core  

Beyond Aroma: Analytical Challenges, Metabolism and Biological Significance of Volatile Sulfur Compounds in Tomato Plants. [PDF]

Int J Mol Sci
Nawrocka J, Szymczak K, Świercz-Pietrasiak U, Bonikowski R.   +3 more
europepmc   +1 more source

Studies on Heteropentales. IV : Heteroannelations to Pyrrolo[2,1-b]benzothiazole and Pyrrolo[2,1-b]thiazoles

2,3-Dibenzoylpyrrolo[2,1-b]benzothiazole (2) and 6,7-dibenzoylpyrrolo[2,1-b]thiazoles (5a-b) have been synthesized by utilizing the cycloaddition reactions of imidazo[2,1-b]benzothiazole and imidazo[2,1-b]thiazoles, respectively, with dibenzoylacetylene ...
Nishiwaki, Tarozaemon, Harada, Emiko, 阿部, 憲孝, Omori, Toshimasa   +3 more
core  

Synthesis, Characterization, and DFT of Some Thiazole Derivatives as Carbon Steel Corrosion Inhibitors in 1 M HCl. [PDF]

Chem Biodivers
Mahmoud AO, Elewady GY, Suliman AE, Ouf AM, Abdel-Ghani GE.   +4 more
europepmc   +1 more source

Structural planning, synthesis and evaluation of properties trypanocidal aryl-1,3-thiazoles

, 2016
FACEPE, CAPES, CNPq.Chagas disease is a parasitic infection caused by protozoan T. cruzi, which affects around 7 million people worldwide. Benznidazole (BZD) is the sole drug approved for treatment during the acute and asymptomatic chronic phases ...
Oliveira, Ulisses José Félix Tenório de, Miranda Filho, Carlos André Laranjeira, Moreira, Diogo Rodrigo Magalhães, Meira, Cássio Santana, Soares, Milena Botelho Pereira, Leite, Ana Cristina Lima, Barbosa, Miria de Oliveira, Siqueira, Lucianna Râbelo Pessôa de, Oliveira Filho, Gevanio Bezerra de, Oliveira, Arsênio Rodrigues   +9 more
core