Results 121 to 130 of about 12,572 (245)

GMP‐compliant production, validation and dosimetry of clinical grade [18F]3‐(3‐fluoropropyl)‐2‐phenyl‐2,3‐dihydrobenzo[d]thiazole ([18F]FPBT) for oxidative stress PET imaging

British Journal of Pharmacology, Volume 183, Issue 20, Page 6028-6045, October 2026.
Background and Purpose Oxidative stress plays a critical role in the pathophysiology of various diseases, yet current methods for its non‐invasive detection remain limited. This study aimed to systematically validate a superoxide‐selective PET tracer, [18F]FPBT, for the early diagnosis and therapeutic monitoring of oxidative stress‐related conditions ...
Hua Zhang, Fangfang Sun, Chun Li, Xin Wang, Yuexuan Song, Lu Jiang, Paul Gape, Samantha Y. A. Terry, Shujun He, Ran Yan, Zhi Lu   +10 more
wiley   +1 more source

The ZmRACK1–ZmCDPK7–ZmAPX1 module regulates plant antiviral immunity

Journal of Integrative Plant Biology, Volume 68, Issue 10, Page 3830-3845, October 2026.
In maize, ZmRACK1 acts as a scaffold protein that bridges the cyclin‐dependent kinase ZmCDPK7 and the ascorbate peroxidase ZmAPX1, promoting ZmAPX1 activity to mitigate MCMV infection. Upon viral infection, P31 obstructs formation of the ZmRACK1‐ZmCDPK7‐ZmAPX1 complex, inhibiting ZmCDPK7‐mediated ZmAPX1 activity and promoting reactive oxygen species ...
Yuyang Zhang, Niannian Li, Qiongqiong Wang, Yingchao Sun, Yajuan Shi, Lianwei Yu, Xiaoyu Han, Xiaoxi Feng, Zaifeng Fan, Linlin Chen, Honglian Li, Xue Yang, Hongxia Yuan, Yan Shi   +13 more
wiley   +1 more source

Synthesis of 4-(coumarin-3-yl)-2-(3,5-dimethyl-4-hydrazoarylpyrazol-1-yl)thiazoles (1a-1g).

, 2018
Synthesis of 4-(coumarin-3-yl)-2-(3,5-dimethyl-4-hydrazoarylpyrazol-1-yl)thiazoles (1a-1g).
Mukesh Kumari (5122631), Indresh K. Maurya (5122625), Ramesh Kataria (5122628), Sunil Kumar (102321), Vinod Kumar (48743), Vikram Saini (34826), Jayant Sindhu (634210)   +6 more
core   +1 more source

Safety of benfotiamine as a Novel food pursuant to Regulation (EU) 2015/2283 and the bioavailability of benfotiamine as a source of thiamin in the context of Directive 2002/46/EC on food supplements

EFSA Journal, Volume 24, Issue 10, October 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of benfotiamine as a novel food (NF) pursuant to Regulation (EU) 2015/2283 and on the bioavailability of benfotiamine as a source of thiamin in the context of Directive 2002/46/EC ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Francesco Cubadda, Thomas Frenzel, Ursula Gundert‐Remy, Francesca Marcon, Harry J. McArdle, Monika Neuhäuser‐Berthold, Miguel Prieto Maradona, Alexandros Siskos, Matthew Wright, Gabriela Precup, Silvia Valtueña Martinez, Hanna Schmierer, Karen Ildico Hirsch‐Ernst   +27 more
wiley   +1 more source

Lichtgesteuerte Dosierung der PPARγ‐Aktivierung Mittels Schnell Relaxierender Photoschalter

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
Um eine räumlich‐zeitliche Kontrolle der PPARγ‐Aktivität zu ermöglichen, entwickelten wir den schnell relaxierenden photoschaltbaren Agonisten 6, der PPARγ selektiv in seinem lichtinduzierten Z‐Zustand aktiviert und innerhalb von Sekunden (t1/2 = 47 s) in den inaktiven E‐Zustand relaxiert.
Loris Knümann, Alba Rodriguez‐Paniagua, Martin Reynders, Silke Duensing‐Kropp, Oliver Thorn‐Seshold, Vasily Morozov, Julian A. Marschner, Daniel Merk   +7 more
wiley   +1 more source

Thiazole Effect on Phycomyces [PDF]

Proceedings of the National Academy of Sciences, 1941
W J, Robbins, F, Kavanagh
openaire   +2 more sources

Dosing PPARγ Activation With Light Using Fast Relaxing Photoswitches

Angewandte Chemie International Edition, Volume 65, Issue 40, 28 September 2026.
To achieve spatiotemporal control over PPARγ activity, we designed the fast‐relaxing photoswitchable agonist 6 that selectively activates PPARγ in its light‐induced Z‐state and relaxes within seconds (t1/2 47 s) to the inactive E‐state. This unique profile allowed light‐dosed receptor activation in in vitro settings, enabling biological studies on ...
Loris Knümann, Alba Rodriguez‐Paniagua, Martin Reynders, Silke Duensing‐Kropp, Oliver Thorn‐Seshold, Vasily Morozov, Julian A. Marschner, Daniel Merk   +7 more
wiley   +1 more source

AN IMPROVED PROCEDURE FOR THE PREPARATION OF SUBSTITUTED THIAZOLES

, 1993
The reaction between 3-amino-3-(dialkylamino)propenenitriles 1 and sodium thiocyanate in presence of bromine, provides an efficient route for the synthesis of 2-amino-5-cyano-4-(dialkylamino)thiazoles ...
COCCO MT, ONNIS, VALENTINA
core  

Artificial Intelligence and Virtual Screening to Identify Small Molecules Inhibiting Transglutaminase 2 for Investigation and Treatment of Breast Cancer

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Artificial Intelligence (AI)‐guided screening of nearly 10 million molecules hit the bull’s‐eye: G11, a new nonpeptidic inhibitor of transglutaminase 2. A stepwise path from in silico ranking to cell and biochemical assays identified G11 as the top hit. It induced apoptosis in transglutaminase 2 (TG2)‐rich breast cancer cells and inhibited purified TG2,
Carlo M. Bergamini, Niel M. Henriksen, Brianna Ryan, Taylor A. Prince, Anna Terrazzan, Pietro Ancona, Cristina Zuccato, Gianluca Aguiari, Valentina Rosta, Jeffrey W. Keillor, Alessandro Trentini, Nicoletta Bianchi   +11 more
wiley   +1 more source

Synthesis and antimicrobial activity of novel 2,4-disubstituted thiazoles / [PDF]

, 2019
beneficial modifications of 2-substituted thiazoles by incorporating different functional groups into the structure such as carboxyl, chloromethyl, (phenylamino)methyl, ethoxyoxoethyl, which determine a certain chemical reactions of the compound was ...
Novikov, Volodymyr,, Grybaitė, Birutė,, Vaickelionienė, Rita,, Mickevičius, Vytautas,, Zvarych, Viktor,   +4 more
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