Results 101 to 110 of about 15,973 (252)

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma [PDF]

, 2017
Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (
Albert, Alekseyenko, Barretina, Baumli, Buettner, Bösken, Chan, Chen, Elkins, Fece de la Cruz, Filippakopoulos, Flaherty, French, Garnett, Grayson, Gregory, Greifenberg, Hortobagyi, Hu, Huang, Hyman, Iorio, Itzen, Kandoth, Kumar, Lam, Lemke, Lorenzin, Lu, Martins, McLornan, Morales, Nojima, Odawara, Reynoird, Riniker, Rosell, Rossi, Seashore-Ludlow, Shaw, Sos, Sos, Squires, Stathis, Stock, Van Cutsem, Walsby, Yan, Yu, Zhang, Zhang, Zou   +51 more
core   +2 more sources

Integrating tunable LED‐induced plant responses with novel solar cell technologies for energy‐efficient agrivoltaic systems

PLANTS, PEOPLE, PLANET, EarlyView.
The increasing demand for sustainable food production requires innovative solutions that balance productivity, resource efficiency, and environmental impact. Vertical Farming Systems (VFSs) offer a promising approach; however, their high energy consumption remains challenging.
Alessio Dessì, Carlo Spampinato, Fabiano Sillo, Salvatore Valastro, Mauro Centritto, Cecilia Brunetti, Andrea Ghirardo, Jörg‐Peter Schnitzler, Alessandra Alberti, Gianna Reginato, Aurora Rizzo, Raffaella Balestrini   +11 more
wiley   +1 more source

Utility of 3-Acetyl-6-bromo-2H-chromen-2-one for the Synthesis of New Heterocycles as Potential Antiproliferative Agents

Molecules, 2015
Coumarin derivatives containing pyrazolo[1,5-a]pyrimidine, tetrazolo[1,5-a]pyrimidine, imidazo[1,2-a]pyrimidine, pyrazolo[3,4-d]pyrimidine, 1,3,4-thiadiazoles and thiazoles were synthesized from 6-bromo-3-(3-(dimethylamino)acryloyl)-2H-chromen-2-one ...
Sobhi M. Gomha, Yasser H. Zaki, Abdou O. Abdelhamid   +2 more
doaj   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Synthesis and Cytotoxicity Evaluation of Some Novel Thiazoles, Thiadiazoles, and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones Incorporating Triazole Moiety

Molecules, 2015
Reactions of hydrazonoyl halides and each of methyl 2-(1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)ethylidene)hydrazine-1-carbodithioate and 2-(1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)ethylidene)hydrazine-1-carbothioamide afforded 2-(1-(5-methyl-1 ...
Sobhi M. Gomha, Sayed A. Ahmed, Abdou O. Abdelhamid   +2 more
doaj   +1 more source

Ecology and Evolution of Soil Nematode Chemotaxis [PDF]

, 2018
Plants influence the behavior of and modify community composition of soil-dwelling organisms through the exudation of organic molecules. Given the chemical complexity of the soil matrix, soil-dwelling organisms have evolved the ability to detect and ...
Ali, Jared, Helder, Johannes, Rasmann, Sergio, van der Putten, Wim   +3 more
core  

A Unique Tryptophan C‐Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway [PDF]

, 2016
Acknowledgements This work was supported by funding of the Academy of Finland (259505), Helsinki University Research grant (490085) and ESCMID grant (4720572) to D.P.F., University of Pittsburgh Central Research Development Fund to X.L., Technology ...
Arnison, Bent, Donia, Donia, Donia, Houssen, Hulvová, Ishida, Ishida, Koehnke, Leikoski, Leikoski, Leikoski, Li, Magnuson, Martin, McIntosh, Shanks, Sivonen, Tsuji, Wallwey, Williams   +21 more
core   +2 more sources

Dimethyl‐, Diethyl‐, and Propylene Carbonates: An Emerging Class of Green Solvents for Organic Synthesis

The Chemical Record, EarlyView.
This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros, Livia C. L. Valente, Thiago Barcellos, Daniela Hartwig, Laura Abenante, Eder J. Lenardão   +5 more
wiley   +1 more source

Methyl (1aRS,7aSR)-7-formyl-1a-phenyl-1,1a-dihydroazirino[2,3-b]benzo[e][1,4]thiazine-7a(7H)-carboxylate

Molbank
The first representative of the aziridine-fused benzo[e][1,4]thiazine series was synthesized from methyl 2-bromo-2-phenyl-2H-azirine-2-carboxylate and benzo[d]thiazole in 74% yield.
Ilya P. Filippov, Anastasiya V. Agafonova, Nikolai V. Rostovskii, Mikhail S. Novikov   +3 more
doaj   +1 more source

Neuere heterocyclische Zwischenprodukte für die Azokupplung durch Cyclisierung von Nitrilen

CHIMIA, 1980
Two types of syntheses of heteroaromatic amines by cyclization of nitriles are described. It is dealt with the cyclization of nitriles by elemental sulphur yielding thiophenes and thiazoles and with some reactions of the resulting 2-amino-thiophene-3 ...
Karl Gewald
doaj   +1 more source